Cold antibody autoimmune haemolytic anaemia in a child with diffuse large B cell lymphoma

Uzunova, Lena; Hook, C. Elizabeth; Gattens, Michael; Burke, G A Amos

doi:10.1007/s00277-015-2498-5

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2016

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“…Acquired Coombs negative hemolytic anemia (CNHA) is rare in the adolescent age group. The differential diagnosis of CNHA (nonimmune hemolysis) associated with splenomegaly, in pediatric patients, includes both inherited and acquired causes such as hemoglobinopathies, RBC enzyme or membrane defects, infections, toxins, HLH, immunodeficiencies, microangiopathies, and uncommonly neoplasms [ 13 , 14 ]. Splenectomy is rarely performed in these patients but may be indicated in severe refractory immune mediated hemolysis, recurrent splenic sequestration, or hypersplenism [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation

Batra

Martin

Nassiri

et al. 2016

Case Reports in Oncological Medicine

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Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.

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Section: Discussionmentioning

confidence: 99%