Cold air challenge of airway reactivity in children: A correlation of transcutaneously measured oxygen tension and conventional lung functions

Eber, Ernst; Varga, Eva‐Maria; Zach, M

doi:10.1002/ppul.1950100409

Cited by 9 publications

(2 citation statements)

References 22 publications

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“…The mean fall in the tcPo2 at reaction in the present study was 24%, a somewhat smaller reduction than observed in a previous study in which we used a 50% fall in the total respiratory resistance to assess a significant bronchial reaction (1 1). A similar fall in the tcPo2 has previously also been reported during provocation with metacholine (7) and cold air (6) in children. The somewhat more moderate reduction in the tcPo2 values at reaction observed in the present study may be explained by the fact that the measurements were made at specific time intervals, which were not always at their lowest levels as in the previous studies.…”

Section: Discussionsupporting

confidence: 86%

Influence of breathing pattern on transcutaneous oxygen and carbon dioxide tension during histamine provocation in children with bronchial asthma

Holmgren¹,

Bjure²,

Engström³

et al. 1996

Acta Paediatrica

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The influence of the breathing pattern on transcutaneous blood gases was evaluated in 18 boys and 8 girls 7-18 years of age, with bronchial asthma, during bronchial provocation with histamine-HCl. Transcutaneous oxygen tension (tcPO2), carbon dioxide tension (tcPCO2) and the breathing pattern assessed by the transthoracic impedance technique were continuously monitored during the provocation. At reaction, when the fall in the forced expiratory volume in 1 s (FEV1) was 20% or more, the tcPO2 fell by 15% or more below the baseline in 22/26 and by 20% or more in 14/26 children. In some children, a marked fall in the tcPO2 was already noted after the saline inhalation and the first histamine dose steps without simultaneous changes in the FEV1. This early fall in the tcPO2 correlated to changes in the breathing pattern and was interpreted as a sign of compensatory hypoventilation secondary to the hyperventilation observed during the inhalations. We conclude that transcutaneous oxygen tension can be used as an indicator of a bronchial reaction during bronchial provocation tests in children only if one takes account of the fact that the breathing pattern during the inhalation of the challenge compound per se has an effect on the oxygen tension.

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Section: Discussionsupporting

confidence: 86%

Influence of breathing pattern on transcutaneous oxygen and carbon dioxide tension during histamine provocation in children with bronchial asthma

Holmgren¹,

Bjure²,

Engström³

et al. 1996

Acta Paediatrica

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“…Although Ptc,O 2 may not be an accurate measure of arterial oxygen tension (Pa,O 2 ), Ptc,O 2 and Pa,O 2 covariate during acute asthma in young and in older children and even after inhalation of the potent vasodilator, the b 2 -agonist [20,21,43]. Ptc,O 2 has previously been found to correlate to the clinical state [44], to respiratory impedance measurements [41,45], and to spirometry [46], with a precision that compared favourably with the latter [47]. In this study, Ptc,O 2 exhibited a covariation with the "gold standard" measurements of sRaw and FEV1.…”

Section: Discussionmentioning

confidence: 99%

Lung function measurement in awake young children

Bisgaard¹,

Klug²

1995

Eur Respir J

251

208

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Keywords: interrupter lung function oscillometry spirometry transcutaneous measurements of oxygen whole body plethysmography young children Received: December 14 1994 Accepted after revision August 28 1995 This study was supported by grants from the Danish Ministry of Health and from Astra-Draco, Lund, Sweden.Eur Respir J, 1995, 8, 2067-2075 DOI: 10.1183 ) were compared with concomitant measurements of specific airway resistance (sRaw) and forced expiratory volume in one second (FEV1) by whole body plethysmography and spirometry, respectively, during methacholine challenge in 21 young children aged 4-6 yrs, with suspected asthma. Measurements with each technique were repeated after each challenge step. A special face-mask was developed with an integrated mouthpiece which ensured mouth breathing during the measurements.The order of sensitivity of the techniques to assess methacholine-induced changes in lung function was ZIOS > sRaw > Ptc,O 2 > FEV1 > Rint. ZIOS was significantly more sensitive than all subsequent methods, and Ptc,O 2 was significantly more sensitive than FEV1. ZIOS, sRaw and Rint, but not Ptc,O 2 and FEV1, detected the subclinical increase in bronchial muscle tone in the children during baseline, which was revealed by the significantly reduced airway obstruction after inhalation of a b b b b b 2 -agonist as compared to baseline.It is concluded that ZIOS, Rint and Ptc,O 2 change in parallel with sRaw and FEV1 and with a comparable sensitivity during simultaneous measurements of the response to methacholine in young children aged 4-6 yrs. This implies that ZIOS, Rint and Ptc,O 2 provide convenient indices of changes in lung function. Their combined use will be useful for monitoring airway diseases of young children.

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Measurement of lung function in awake 2–4-year-old asthmatic children during methacholine challenge and acute asthma: A comparison of the impulse oscillation technique, the interrupter technique, and transcutaneous measurement of oxygen versus whole-body plethysmography

1996

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Cold air challenge of airway reactivity in children: A correlation of transcutaneously measured oxygen tension and conventional lung functions

Cited by 9 publications

References 22 publications

Influence of breathing pattern on transcutaneous oxygen and carbon dioxide tension during histamine provocation in children with bronchial asthma

Influence of breathing pattern on transcutaneous oxygen and carbon dioxide tension during histamine provocation in children with bronchial asthma

Lung function measurement in awake young children

Measurement of lung function in awake 2–4-year-old asthmatic children during methacholine challenge and acute asthma: A comparison of the impulse oscillation technique, the interrupter technique, and transcutaneous measurement of oxygen versus whole-body plethysmography

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