Cold agglutinin disease

Linz, Walter J.; Tauscher, Craig D.; Winters, Jeffrey L.; Gastineau, Dennis A.; Moore, Breanndan

doi:10.1046/j.1537-2995.2003.00502.x

Cited by 5 publications

(2 citation statements)

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“…Plasmapheresis has been documented as a successful treatment for cold agglutinin disease 17,18 and also hemolysis associated with infectious mononucleosis. 19 In cold agglutinin disease, the IgM autoantibody is confined to the intravascular space resulting in intravascular hemolysis.…”

Section: Discussionmentioning

confidence: 99%

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Successful Plasmapheresis for Extreme Hyperbilirubinemia Caused by Acute Epstein-Barr Virus

Place

Wenzel²,

Arumugam³

et al. 2007

Journal of Pediatric Hematology/Oncology

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Epstein-Barr virus (EBV) infection can be complicated by cholestatic jaundice and hemolytic anemia, although both complications rarely occur simultaneously. An 18-year-old female developed acute EBV infection complicated by cold agglutinin hemolysis and cholestasis. Corticosteroid and ursodeoxycholic acid were initiated but bilirubin peaked at 1297.47 micromol/L (75.7 mg/dL). Plasmapheresis was initiated and with the corticosteroids, resulted in resolution of extreme hyperbilirubinemia. The patient recovered rapidly, is healthy 2 years later and is neurologically intact. The early use of plasmapheresis with corticosteroids and ursodeoxycholic should be considered in EBV infections complicated by extreme hyperbilirubinemia to prevent the rare complication of adult-onset kernicterus.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, corticosteroid therapy alone may be sufficient, but the use of plasmapheresis therapy offers an effective emergency intervention. 18 In cold agglutinin disease, the response rate to corticosteroids may be less than 20%, and chronic plasmapheresis may be needed.…”

Section: Discussionmentioning

confidence: 99%