Cold Agglutinin Disease After Hepatitis A Infection in a Child

Polat, Azız; Inan, Murat

doi:10.1097/00043426-200310000-00022

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…CAS is rare in children and is usually secondary to infections caused by bacteria, such as Mycoplasma pneumoniae or viruses, such as Epstein Barr, varicella zoster, or cytomegalovirus (10, 11). In case #2 no clinical or laboratory evidence of infection was observed at the onset of anemia, so we concluded that infection was not a likely cause of hemolysis in this patient.…”

Section: Discussionmentioning

confidence: 99%

Cold agglutinin syndrome in pediatric liver transplant recipients

Wong¹,

Merker²,

Nguyen

et al. 2007

Pediatric Transplantation

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Anemia is a common finding in post-liver transplant patients. Causes for the anemia include nutritional deficiencies, red cell aplasia as well as immune-mediated hemolysis. One of the immunologic causes of hemolytic anemia is drug-induced hemolysis. Tacrolimus is a common immunosuppressant used in post-liver transplant patients to prevent graft rejection. There have been reports of tacrolimus-associated hemolytic anemia secondary to hemolytic uremic syndrome as well as autoimmune hemolysis. There are also case-reports of severe hemolytic anemia related to cold agglutinin production in post-liver transplant patients. We described in this paper three cases of severe cold agglutinin hemolytic anemia in three pediatric liver transplant patients. Steroid therapy, plasmapheresis and withdrawal of tacrolimus led to resolution of the severe hemolytic process in each case. Whether the immune-mediated hemolysis is related to tacrolimus is not clear and needs to be characterized further.

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Section: Discussionmentioning

confidence: 99%

Cold agglutinin syndrome in pediatric liver transplant recipients

Wong¹,

Merker²,

Nguyen

et al. 2007

Pediatric Transplantation

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show abstract

“…CAS is rare in children and typically occurs following an infection—viral URI, EBV, mycoplasma, adenovirus, varicella, hepatitis A, Legionella 8–10. However, CAS has also been described following allogenic bone marrow transplant 11, 12 and in association with malignancy 13, 14.…”

Section: Discussionmentioning

confidence: 99%