Cold Adaptation in Ectotherms: Regulation of Membrane Function and Cellular Metabolism

Hazel, Jeffrey R.

doi:10.1007/978-3-642-74078-7_1

Cited by 55 publications

(56 citation statements)

References 214 publications

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“…3 Ohtsu et al, 1993;Hazel, 1989;Hazel, 1995;Hochachka and Somero, 2002;Haubert et al, 2008;Van Dooremalen and Ellers, 2010;Koštál, 2010;Goto and Katagiri, 2011). A relationship between increased FA unsaturation (UFAs/SFAs ratio), and diapause initiation has been observed in many insect species (Kuthiala and Chippendale, 1989;Ohtsu et al, 1993;Bennet et al, 1997;Buckner and Hagen, 2003;Bashan and Cakmak, 2005;Michaud and Denlinger, 2006;Koštál, 2010;Vukašinović et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…One of the predicted ways to achieve HVA is that membrane FAs become more unsaturated, together with changes in phospholipid headgroups and cholesterol content, during a cold response. HVA compensate the negative effect of membrane solidification which can lead to reduced efficiency of proteins and enzymes associated with the membrane at low temperature and alter its permeability (Sinensky, 1974;Hazel, 1989;Hazel, 1995;Hochachka and Somero, 2002;Koštál, 2010 (Grubor-Lajsic et al, 1991, 1992Kojić et al, 2010). The pentose phosphate pathway, which is intensive during early and mid diapause, serves as a source of NADPH that plays a vital role in the antioxidative defence system and the intensive biosynthetic pathways of protective molecules (Stanić et al, 2004;Jovanović-Galović et al, 2004;Jovanović-Galović et al, 2007).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Also, MUFAs, due to the central position of the double bond in FA, maximize the lateral displacement of the end of the chain and contribute to overall membrane disorder (Barton and Gunston, 1975). Thus, high levels of cis oleic acid The seasonal increase in overall FA unsaturation of storage and membrane lipids is considered to be an adaptation to optimize phase behaviour that is crucial for controlling membrane fluidity and storage utilization during low winter temperatures (Sinesky, 1974;Hazel, 1989;Hazel, 1995;Hazel and Williams, 1990;Ohtsu et al, 1993;Kostal and Simek, 1998;Hochachka and Somero, 2002;Koštál et al, 2003;Michaud and Denlinger, 2006;Overgaard et al, 2008;Van Dooremalen and Ellers, 2010;Rozsypal et al, 2014). Namely, increased FA unsaturation of membrane phospholipids contributes to the maintenance of the vital static order and dynamic properties of membranes whereas triacylglycerols maintain the fluidity of storage lipids facilitating accessibility of enzymes to energy lipid reserves during periods of low winter temperatures.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Beside the biosynthesis of low molecular weight organic solutes, which function as cryo/anhydroprotectants and play a role in the preservation of the structural and functional integrity of membranes, adjustments of FA composition of membrane and storage lipids is another important physiological mechanism underlying phenotypic responses to low temperature (Sinesky, 1974;Cossins and Raynard, 1987;Hazel, 1989;Hazel, 1995). FAs, as the main constituents of membrane and storage lipids, have a major influence on cold hardiness.…”

Section: Introductionmentioning

confidence: 99%

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Diapause induces remodeling of the fatty acid composition of membrane and storage lipids in overwintering larvae of Ostrinia nubilalis, Hubn. (Lepidoptera: Crambidae)

Vukašinović

Pond

Worland

et al. 2015

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Diapause induces remodelling of the fatty acid composition of membrane and storage lipids in overwintering larvae of Ostrinia nubilalis, Hubn. (Lepidoptera: Crambidae), Comparative Biochemistry and Physiology, Part B (2015), doi: 10.1016/j.cbpb.2015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diapause induces remodeling of the fatty acid composition of membrane and storage lipids in overwintering larvae of Ostrinia nubilalis, Hubn. (Lepidoptera: Crambidae)

Vukašinović

Pond

Worland

et al. 2015

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…The ACC is located between 50°S and 60°S and is the largest current on Earth in terms of both length and transport capacity (Gordon, 1999 (Detrich et al, 1989(Detrich et al, , 2000Redeker, et al, 2004), the evolution of membranes that maintain their fluidity at cold temperatures, i.e. homeoviscous adaptation (Hazel, 1984;Logue et al, 2000), and the reorganization of metabolic pathways (Crockett and Sidell, 1990;Magnoni et al, 2013) play a significant role in optimizing function at sub-zero temperature. In contrast, the loss of critical functional traits such as the inducible HSR (Hofmann et al, 2000;Buckley et al, 2004;Place et al, 2004) and the oxygen-binding proteins Hb and myoglobin (Mb), which are tolerated because of low and stable temperatures, is thought to play a key role in determining the extreme stenothermy of notothenioids (Ruud, 1954;Cocca et al, 1995;Sidell et al, 1997).…”

Section: Adaptations To Living In Chronically Frigid Watersmentioning

confidence: 99%

Antarctic notothenioid fish: what are the future consequences of ‘losses’ and ‘gains’ acquired during long-term evolution at cold and stable temperatures?

Beers

Jayasundara

2015

Journal of Experimental Biology

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Antarctic notothenioids dominate the fish fauna of the Southern Ocean. Evolution for millions of years at cold and stable temperatures has led to the acquisition of numerous biochemical traits that allow these fishes to thrive in sub-zero waters. The gain of antifreeze glycoproteins has afforded notothenioids the ability to avert freezing and survive at temperatures often hovering near the freezing point of seawater. Additionally, possession of cold-adapted proteins and membranes permits them to sustain appropriate metabolic rates at exceptionally low body temperatures. The notothenioid genome is also distinguished by the disappearance of traits in some species, losses that might prove costly in a warmer environment. Perhaps the best-illustrated example is the lack of expression of hemoglobin in white-blooded icefishes from the family Channichthyidae. Loss of key elements of the cellular stress response, notably the heat shock response, has also been observed. Along with their attainment of cold tolerance, notothenioids have developed an extreme stenothermy and many species perish at temperatures only a few degrees above their habitat temperatures. Thus, in light of today's rapidly changing climate, it is critical to evaluate how these extreme stenotherms will respond to rising ocean temperatures. It is conceivable that the remarkable cold specialization of notothenioids may ultimately leave them vulnerable to future thermal increases and threaten their fitness and survival. Within this context, our review provides a current summary of the biochemical losses and gains that are known for notothenioids and examines these cold-adapted traits with a focus on processes underlying thermal tolerance and acclimation capacity.

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Cost effective, robust, and reliable coupled separation techniques for the identification and quantification of phospholipids in complex biological matrices: Application to insects

et al. 2014

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The quantification of phospholipid classes and the determination of their molecular structures are crucial in physiological and medical studies. This paper's target analytes are cell membrane phospholipids, which play an important role in the seasonal acclimation processes of poikilothermic organisms. We introduce a set of simple and cost-effective analytical methods that enable efficient characterization and quantification of particular phospholipid classes and the identification and relative distribution of the individual phospholipid species. The analytical approach involves solid-phase extraction and high-performance thin-layer chromatography, which facilitate the separation of particular lipid classes. The obtained fractions are further transesterified to fatty acid methyl esters and subjected to gas chromatography coupled to flame ionization detection, which enables the determination of the position of double bonds. Phospholipid species separation is achieved by high-performance liquid chromatography with mass spectrometry, which gives information about the headgroup moiety and attached fatty acids. The total content of each phospholipids class is assessed by phosphorus determination by UV spectrophotometry. The simultaneous analysis of phosphorus, fatty acid residues, and phospholipid species provides detailed information about phospholipid composition. Evaluation of these coupled methods was achieved by application to an insect model, Pyrrhocoris apterus. High correlation was observed between fatty acid compositions as determined by gas chromatography and high-performance liquid chromatography analysis.

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Cold Adaptation in Ectotherms: Regulation of Membrane Function and Cellular Metabolism

Cited by 55 publications

References 214 publications

Diapause induces remodeling of the fatty acid composition of membrane and storage lipids in overwintering larvae of Ostrinia nubilalis, Hubn. (Lepidoptera: Crambidae)

Diapause induces remodeling of the fatty acid composition of membrane and storage lipids in overwintering larvae of Ostrinia nubilalis, Hubn. (Lepidoptera: Crambidae)

Antarctic notothenioid fish: what are the future consequences of ‘losses’ and ‘gains’ acquired during long-term evolution at cold and stable temperatures?

Cost effective, robust, and reliable coupled separation techniques for the identification and quantification of phospholipids in complex biological matrices: Application to insects

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