Colchicine-related death presenting as an unknown case of multiple organ failure

Miller, Michael A.; Hung, Yao-Min; Haller, Christine; Galbo, Mark; Levsky, Marc E.

doi:10.1016/j.jemermed.2004.12.012

Cited by 23 publications

(19 citation statements)

References 18 publications

(26 reference statements)

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“…The time frame used for our clinical observation and length of study, followed closely the published plasma half-life (4 h) for COL and its detection in leukocytes (10 days) (Molad, 2002). Therefore in general, the progressive toxicity of COL occurred in degrees and stages similar to that described in humans by Miller et al (2005). In humans the first stage is marked by the onset of gastrointestinal symptoms.…”

Section: −1mentioning

confidence: 69%

Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre‐exposure to lipopolysaccharide

Wiesenfeld

Garthoff

Sobotka

et al. 2007

J of Applied Toxicology

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The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg(-1) body weight) of colchicine (COL) was determined in young, mature male and female Sprague-Dawley rats. The effect of COL was evaluated in the presence or absence of additional treatment variables that included vehicle and lipopolysaccharide (LPS) pre-exposure. The vehicle for COL was either Half and Half cream (H & H) or saline, and each group included pretreatment with either saline or a low, minimally toxic dose (83 microg kg(-1) body weight) of LPS. Colchicine toxicity in both male and female age-matched rats was characterized by progressively more severe dose-related clinical signs of toxicity. These included mortality, decreased body weight and feed intake during the first several days after dosing, with recovery thereafter in surviving animals. There were differences in the severity of the toxic response to COL between male and female rats. The most notable sex-related difference was in COL lethality. Female rats were two times more susceptible to the lethal effects of COL than male rats. Saline or H & H delivery vehicles did not result in any apparent qualitative or quantitative differences in COL toxicity. LPS pretreatment significantly potentiated COL lethality in both males and females, although the potentiation in males was greater than in females. LPS pretreatment modestly increased the COL induced anorexic effect in surviving males, but not in surviving female animals. LPS did not appear to modulate either the body weights or clinical signs of COL induced toxicity in surviving males or females.

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Section: −1mentioning

confidence: 69%

Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre‐exposure to lipopolysaccharide

Wiesenfeld

Garthoff

Sobotka

et al. 2007

J of Applied Toxicology

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“…Unfortunately, it is genotoxic by virtue of its ability to inhibit mitosis and has a narrow therapeutic index in relation to gastrointestinal problems [1]. In addition, reports of death caused by accidental ingestion of meadow saffron [2][3][4] demonstrate that a dose of colchicine over 0.8 mg/kg usually results in cardiogenic shock [1]. In clinical use, colchicine is administered at a dose of 1-2 mg requiring a sensitive analytical method to measure the low concentrations found in human plasma.…”

Section: Introductionmentioning

confidence: 99%

Rapid and sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of colchicine in human plasma

Jiang

Wang

et al. 2007

Journal of Chromatography B

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“…1,17 The typical haemopoietic manifestation is initial leukocytosis followed by profound pancytopaenia, which usually begins 48e72 h after poisoning. 18 In our case, we observed thrombocytopaenia, raised blood urea and serum creatinine.…”

Section: Discussionmentioning

confidence: 99%

Suicidal plant poisoning with Colchicum autumnale

Nagesh

Menezes

Rastogi

et al. 2011

Journal of Forensic and Legal Medicine

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Colchicine-related death presenting as an unknown case of multiple organ failure

Cited by 23 publications

References 18 publications

Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre‐exposure to lipopolysaccharide

Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre‐exposure to lipopolysaccharide

Rapid and sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of colchicine in human plasma

Suicidal plant poisoning with Colchicum autumnale

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