Colchicine mesoporous silica nanoparticles/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management

Mohamed, Amina L.; Elmotasem, Heba; Salama, Abeer

doi:10.1016/j.ijbiomac.2020.07.133

Cited by 69 publications

(40 citation statements)

References 72 publications

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“…Colchicine (CLC) is a water-soluble alkaloid extracted from Colchicum autumnale L. (Mohamed et al, 2020) and the first therapy of choice in gout treatment (Letter, 1974). Due to its antiinflammatory and anti-fibrosis properties (Leung et al, 2018), CLC is used not only in the treatment of arthritis but also as a remedy to treat numerous skin conditions (Sullivan et al, 1998), Familial Mediterranean fever (Knieper et al, 2017), Behcet's disease (Nava et al, 2014), cirrhosis (Kershenobich et al, 1988;Gong and Gluud, 2004;Rambaldi and Gluud, 2005), and certain carcinomas (Mohamed et al, 2020). Clinical studies have shown that CLC can significantly improve symptoms in KOA patients (Das et al, 2002).…”

Section: Colchicinementioning

confidence: 99%

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Feng

et al. 2022

Front. Pharmacol.

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Osteoarthritis (OA) is a long-term chronic arthrosis disease which is usually characterized by pain, swelling, joint stiffness, reduced range of motion, and other clinical manifestations and even results in disability in severe cases. The main pathological manifestation of OA is the degeneration of cartilage. However, due to the special physiological structure of the cartilage, once damaged, it is unable to repair itself, which is one of the challenges of treating OA clinically. Abundant studies have reported the application of cartilage tissue engineering in OA cartilage repair. Among them, cell combined with biological carrier implantation has unique advantages. However, cell senescence, death and dedifferentiation are some problems when cultured in vitro. Botanical drug remedies for OA have a long history in many countries in Asia. In fact, botanical drug extracts (BDEs) have great potential in anti-inflammatory, antioxidant, antiaging, and other properties, and many studies have confirmed their effects. BDEs combined with cartilage tissue engineering has attracted increasing attention in recent years. In this review, we will explain in detail how cartilage tissue engineering materials and BDEs play a role in cartilage repair, as well as the current research status.

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Section: Colchicinementioning

confidence: 99%

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Feng

et al. 2022

Front. Pharmacol.

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“…The hydrogel was synthesized by reacting carboxyethyl chitosan and oxidized pullulan. The patches when implanted on a mono-iodoacetate (MIA)-induced rat osteoarthritis model showed improved locomotor activity, glutathione blood level, and a significant decrease in levels of malondialdehyde, nitric oxide, TNF-α, and COX-2 [165]. In another interesting approach, Appel et al synthesized shear-thinning, self-healable injectable hydrogels by utilizing hydrophobic interactions between hydroxy-propyl-methyl cellulose derivatives (HPMC-x) and PEG-b-PLA nanoparticles.…”

Section: Self-healing Hydrogels As Drug Delivery Platforms For Other Applicationsmentioning

confidence: 99%

“…Due to the mechanical coupling between cells and ECM, the mechanical properties of the ECM has a profound effect on altering, regulating and modulating cell spreading, cell shape, intercellular communication, and signaling pathways [180]. ECM stiffness is also recognised to play an important role in the directional differentiation of stem cells [165,176]. Neural stem cells are capable of differentiating into neurons and glial cells for neural regeneration; however, their fates are modulated by the stiffness of the scaffold.…”

Section: Ecm Mechanicsmentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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“…The free colchicine or encapsulated drug is then embedded in the self-healing hydrogel. Treatment studies of this drug delivery in a rat osteoarthritis model induced by monoiodoacetic acid (MIA) have shown that nanoparticle/hydrogel patches have an effective and safe therapeutic potential for OA [21]. Oxidative stress is caused by the accumulation of reactive oxygen and nitrogen substances (ROS and RNS) in the cell microenvironment.…”

Section: Liposome the Liposome Is An Artificial Membranementioning

confidence: 99%

Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

Liu

Zhang

Wang

2021

Journal of Nanomaterials

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Osteoarthritis (OA) is a bone and joint disease with pathological characteristics such as articular cartilage degeneration injury and synovial and subchondral bone reactive hyperplasia. Once cartilage is damaged, it is difficult to repair it by itself. Current clinical practice is mainly limited to symptomatic treatment, not changing the degenerative process of osteoarthritis. The important goal of nanomedicine is targeted delivery. Nanoparticles (NPs) can provide many unique potential functions for the targeted treatment of arthritis. This review summarizes the research progress of nanomaterials as a drug delivery system in the treatment of osteoarthritis from three aspects: (1) the etiology of OA and the current research status of applying nanoparticles to treat OA, (2) the construction of osteoarthritis models, and (3) the classification of nanoparticle-based drug delivery systems.

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Colchicine mesoporous silica nanoparticles/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management

Cited by 69 publications

References 72 publications

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment

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