Colchicine is still a chemical marker for the expanded Colchicaceae

Vinnersten, Annika; Larsson, Sven‐Erik

doi:10.1016/j.bse.2010.12.004

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…Investigation of crude alkaloid extracts with mass spectrometry has confirmed that colchicine is present in, and restricted to, the family Colchicaceae [26] consisting of 15 genera and about 280 species, of which more than half belong to genus Colchicum [27]. Plants of both genera Colchicum and Gloriosa contain colchicine in toxic amounts.…”

Section: Sources Of Colchicinementioning

confidence: 99%

A Novel Approach for Production of Colchicine as a Plant Secondary Metabolite by in Vitro Plant Cell and Tissue Cultures

Kefi¹

2018

JAST-A

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The secondary metabolites synthesized by plants are economically important chemical compounds in the agricultural and industrial areas such as food, perfumery and pharmaceutical sectors. In recent years, attempts for their production by in vitro plant cell and tissue cultures have been accelerated considerably. Colchicine, the principle secondary metabolite of Colchicum autumnale L. and Gloriosa superba L., is an important alkaloid that has poison effect used for treatment of various diseases and plant breeding studies. Presently, colchicine has been produced by using the seeds of C. autumnale L. and the tubers of G. superba L. through different chemical extraction methods. Applying in vitro plant cell and tissue cultures together with metabolic and genetic engineering techniques, large-scale production of colchicine can be achieved from the above two plant species.

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Section: Sources Of Colchicinementioning

confidence: 99%

A Novel Approach for Production of Colchicine as a Plant Secondary Metabolite by in Vitro Plant Cell and Tissue Cultures

Kefi¹

2018

JAST-A

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“…Investigation of crude alkaloid extracts with mass spectrometry has also confirmed that colchicine is present in, and restricted to, the genera of Colchicaceae in this wider circumscription [49]. …”

Section: Biological Originmentioning

confidence: 99%

Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry

Larsson¹,

Rønsted

2013

CTMC

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The subject of chemosystematics has provided insight to both botanical classification and drug development. However, degrees of subjectivity in botanical classifications and limited understanding of the evolution of chemical characters and their biosynthetic pathways has often hampered such studies. In this review an approach of taking phylogenetic classification into account in evaluating colchicine and related phenethylisoquinoline alkaloids from the family Colchicaceae will be applied. Following on the trends of utilizing evolutionary reasoning in inferring mechanisms in eg. drug resistance in cancer and infections, this will exemplify how thinking about evolution can influence selection of plant material in drug lead discovery, and how knowledge about phylogenetic relationships may be used to evaluate predicted biosynthetic pathways.

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“…Moreover, to the best of our knowledge, these compounds are for the first time in our study tested towards the fungistatic activity of the microfungi species (Aspergillus niger van Tiegen, A. versicolor, Paecilomyces variotii, Penicillium funiculosum) using the method of bioautography on thin-layer plates. [23] Some complexes were selected from among the new derivatives and tested against brown-rot fungi Coniophora puteana and Poria placenta and also against white-rot fungus Coriolus versicolor using agar and broth dilution method to determine the minimal inhibitory concentration (MIC). Colchicine itself has been tested against A. niger previously and it did not show fungistatic properties against this fungus.…”

Section: Introductionmentioning

confidence: 99%

Human Body Fluid Ions In colchicine complexes ESI MS, MADLI MS, Spectroscopic, DFT Studies and Fungicidal Activity of colchicine complexes With Sodium, Potassium, Magnesium and calcium carbonates and Sulphates

Kurek¹,

Bartkowiak²,

Jankowski³

et al. 2016

IOSRPHR

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Colchicine is an alkaloid characterised by good water solubility. After administration of colchicine as a medicine for example for the treatment of gout, colchicine probably forms some more or less stable structures with cations and/or anions present in human body fluid. The colchicine complexes with Na + , K + Mg 2+ and Ca 2+ cations of sulphates and carbonates have been synthesized and studied by ESI MS, MALDI MS, 1 H and 13 C NMR, FT IR DFT calculations and also have been tested against fungicidal activity. Salts of good solubility in water have been chosen, like Na 2 SO 4 , K 2 SO 4 , Na 2 CO 3 , K 2 CO 3 , MgSO 4 and CaSO 4. It has been shown that colchicine forms stable complexes of 1:1 stoichiometry with monovalent and divalent metal cations. For K + and Na + cations also formation of 2:1 stoichiometry complexes has been detected. Colchicine with sodium sulphate forms much more complicated structures of 1:2:1 and 2:2:1 stoichiometry in which sulphate anion is involved. Colchicine complexes have fungicidal activity.

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Colchicine is still a chemical marker for the expanded Colchicaceae

Cited by 13 publications

References 27 publications

A Novel Approach for Production of Colchicine as a Plant Secondary Metabolite by in Vitro Plant Cell and Tissue Cultures

A Novel Approach for Production of Colchicine as a Plant Secondary Metabolite by in Vitro Plant Cell and Tissue Cultures

Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry

Human Body Fluid Ions In colchicine complexes ESI MS, MADLI MS, Spectroscopic, DFT Studies and Fungicidal Activity of colchicine complexes With Sodium, Potassium, Magnesium and calcium carbonates and Sulphates

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