Colchicine-induced bone marrow suppression: treatment with granulocyte colony-stimulating factor

Harris, Roger; Marx, Gavin; Gillett, Mark; Kark, Adrian; Arunanthy, Shalini

doi:10.1016/s0736-4679(00)00160-8

Cited by 53 publications

(41 citation statements)

References 36 publications

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“…Although rapidly dissolving in water, colchicine has a positive octanol/ water partition coeYcient, i.e., is lipid soluble, and hence is capable of diVusion across cell membranes (Klaassen, 2001). Ingested colchicine is rapidly absorbed across the gastrointestinal epithelium of humans (Harris et al, 2000).…”

Section: Apo Histologymentioning

confidence: 99%

“…Consequently, colchicine has long been used experimentally to visualize metaphase chromosomes in cytogenetic studies, and to induce polyploidy in plants (Eigsti and Dustin, 1955). Although colchicine has been employed as an anti-inXammatory drug, acting in part by disrupting both microtubule-dependent and microtubule-independent functions of neutrophils (Molad, 2002), at doses slightly higher than therapeutic it is quite toxic to humans, resulting in wide ranging eVects, including bone marrow depression, pancytopenia, neuropathy, myopathy, and multi-organ failure (Harris et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we exposed B. glabrata to 0.1% colchicine, representing the lowest eVective dose reported by these authors, for periods ranging from 1 to 72 h, in an attempt to obtain subthreshold (relative to eVects on mitosis), eVective, and toxic doses. Toxicity was assessed by measuring eVects on (1) snail survival, (2) hemocyte concentrations, inasmuch as leukopenia occurs in humans following colchicine-induced bone marrow depression (Harris et al, 2000), and (3) histology of the central nervous system, since colchicine causes apoptosis in hippocampal neurons of rats both in vivo and in vitro (Kristensen et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mitotic arrest and toxicity in Biomphalaria glabrata (Mollusca: Pulmonata) exposed to colchicine

Sullivan

Castro

2005

Journal of Invertebrate Pathology

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Section: Apo Histologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mitotic arrest and toxicity in Biomphalaria glabrata (Mollusca: Pulmonata) exposed to colchicine

Sullivan

Castro

2005

Journal of Invertebrate Pathology

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“…Extracorporeal elimination (hemodialysis and hemoperfusion) is ineffective due to the large volume of distribution of colchicine (12). Granulocytestimulating factor may be used to assist regeneration of suppressed bone marrow, but should be stopped early to avoid extramedullary hematopoiesis, especially in children, although specific guidelines do not exist on this topic (13,14). Experimental treatment with colchicine-specific Fab fragments has been successfully used, but has not been tested in randomized controlled studies or on a large group of patients, and is not commercially available (15).…”

Section: Discussionmentioning

confidence: 99%

Progressive Organ Failure After Ingestion of Wild Garlic Juice

Galland-Decker

Charmoy

Jolliet

et al. 2016

The Journal of Emergency Medicine

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“…18 Following 2 to 3 days of daily dosing, WBCs began to recover and platelet levels improved. In our case, WBC and platelets exhibited a fourfold decline 28 hours postingestion.…”

Section: Discussionmentioning

confidence: 99%

Colchicine overdose with coingestion of nonsteroidal antiinflammatory drugs

Little

Tung²,

Truong

et al. 2014

CJEM

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Colchicine has a low therapeutic index. Its toxic effects generally occur at doses $ 0.5 mg/kg. We present the case of a 39-year-old female with toxicity following ingestion of 0.28 mg/kg. The patient presented to the emergency department (ED) with severe nausea, vomiting, and abdominal pain following an intentional multidrug ingestion that included colchicine, indomethacin, and zopiclone. Despite toxicologic management and supportive care, admission to the intensive care unit was required for clinical deterioration and symptom management. Shock and multiorgan failure resulted, with death occurring 52 hours postingestion. Although the toxic effects of colchicine are well documented, mortality caused by low doses is relatively uncommon. Management of toxicity consists of early diagnosis, decontamination, and supportive measures. Toxicity may be enhanced by drug interactions inhibiting metabolic enzymes or poor excretion due to renal failure. In this case, the ingestion of a nonsteroidal antiinflammatory drug and the associated volume depletion from the gastrointestinal effects of colchicine may have contributed to renal dysfunction, exacerbating the toxicity of colchicine. This ingestion of a relatively small dose of colchicine led to severe toxicity. Treatment options for colchicine toxicity are limited. RÉ SUMÉLa colchicine a un faible indice thé rapeutique. Ses effets toxiques se manifestent gé né ralement à des doses $ 0.5 mg/kg. Sera exposé le cas d'une femme de 39 ans chez qui des signes de toxicité sont apparus aprè s l'ingestion de 0.28 mg/kg de colchicine. La patiente a consulté au service des urgences pour de fortes nausé es, des vomissements et des douleurs abdominales à la suite de l'ingestion volontaire d'un cocktail mé dicamenteux, composé de colchicine, d'indomé thacine et de zopiclone. Malgré une prise en charge toxicologique et des soins de soutien, il a é té nécessaire d'admettre la patiente au service des soins intensifs pour une dé té rioration de l'é tat clinique et la prise en charge des symptô mes. S'en sont suivis un é tat de choc et une dé faillance multiorganique, qui se sont soldé s par la mort de la patiente 52 heures aprè s la prise des mé dicaments. Les effets toxiques de la colchicine sont bien connus, mais il est plutô t rare que de faibles doses de ce mé dicament entraînent la mort. La prise en charge de la toxicité comprend la pose pré coce du diagnostic, la dé contamination et des mesures de soutien. La toxicité peut ê tre aggravé e par les interactions mé dicamenteuses qui inhibent les enzymes mé taboliques ou par la faible excré -tion due à l'insuffisance ré nale. Dans le cas ici exposé , l'ingestion d'un anti-inflammatoire non sté roïdien et la dé plé tion du volume des liquides ré sultant des effets gastro-intestinaux de la colchicine ont pu jouer un rô le dans le dysfonctionnement ré nal, d'où l'intensification de la toxicité de la colchicine. Ainsi, la prise d'une dose relativement faible de colchicine a produit des effets toxiques graves, et les possibilité s de t...

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Colchicine-induced bone marrow suppression: treatment with granulocyte colony-stimulating factor

Cited by 53 publications

References 36 publications

Mitotic arrest and toxicity in Biomphalaria glabrata (Mollusca: Pulmonata) exposed to colchicine

Mitotic arrest and toxicity in Biomphalaria glabrata (Mollusca: Pulmonata) exposed to colchicine

Progressive Organ Failure After Ingestion of Wild Garlic Juice

Colchicine overdose with coingestion of nonsteroidal antiinflammatory drugs

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