Colchicine increases intestinal toxic load by disturbing fecal metabolome homeostasis in mice

Shi, Yu; Li, Jiande; Wang, Ji; Cao, Hanwen; Tian, Huanbing; Yu, Feifei; Gao, Lan

doi:10.1016/j.cbi.2022.110193

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…This suggests that GY-1 cannot directly reduce intestinal toxicity by modifying COL. One possible reason is that GY-1 helps restore the imbalance in the gut microbiota caused by COL (Fig. 7 and 8), which may normalize the intestinal metabolism disrupted by COL. 76 Besides, our data clearly show that GY-1 alone is ineffective in treating gout flares (Fig. S1 †).…”

Section: Papermentioning

confidence: 59%

Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine

Zeng,

Li,

Zou

et al. 2024

Food Funct.

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Section: Papermentioning

confidence: 59%

Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine

Zeng,

Li,

Zou

et al. 2024

Food Funct.

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“…After adaptation, 12 mice were randomly allocated into two groups. The mice in the first group were given 0.9% normal saline by gavage, the second group received COL daily (2.5 mg/kg b. w./day, Cat# 3915, Sigma-Aldrich) for a week based on our previous studies (Shi et al, 2021(Shi et al, , 2022(Shi et al, , 2020. COL was prepared with 0.9% NaCl solution, and the gavage volume of each mouse was determined based on its body weight.…”

Section: Mouse Husbandry and Treatmentmentioning

confidence: 99%

Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice

Shi,

Wei,

Jin

et al. 2024

J of Applied Toxicology

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Although the medicinal properties of colchicine (COL) have been widely known for centuries, its toxicity has been the subject of controversy. The narrow therapeutic window causes COL to induce gastrointestinal adverse effects even when taken at recommended doses, mainly manifested as nausea, vomiting, and diarrhea. However, the mechanism of COL‐induced gastrointestinal toxic reactions remains obscure. In the present study, the mice were dosed with COL (2.5 mg/kg b.w./day) for a week to explore the effect of COL on bile acid metabolism and the mechanism of COL‐induced diarrhea. The results showed that COL treatment affected liver biochemistry in mice, resulting in a significant down‐regulation of the mRNA expression levels of bile acid biosynthesis regulators Cyp7a1, Cyp8b1, Cyp7b1, and Cyp27a1 in liver tissues. The mRNA expression levels of bile acid transporters Ntcp, Oatp1, Mrp2, Ibabp, Mrp3, Osta, and Ostb in liver and ileum tissues were also significantly down‐regulated. In addition, COL treatment significantly inhibited the mRNA expression levels of Fxr and its downstream target genes Shp, Lrh1, and Fgf15 in liver and ileum tissues, affecting the feedback regulation of bile acid biosynthesis. More importantly, the inhibition of COL on bile acid transporters in ileal and hepatic tissues affected bile acid recycling in the ileum as well as their reuptake in the liver, leading to a significantly increased accumulation of bile acids in the colon, which may be an important cause of diarrhea. In conclusion, our study revealed that COL treatment affected bile acid biosynthesis and enterohepatic circulation, thereby disrupting bile acid metabolic homeostasis in mice.

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Probing the molecular mechanism of interaction between polystyrene nanoplastics and catalase by multispectroscopic techniques

Hu¹,

Xu²,

Cui³

et al. 2023

Chemico-Biological Interactions

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Colchicine increases intestinal toxic load by disturbing fecal metabolome homeostasis in mice

Cited by 3 publications

References 46 publications

Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine

Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine

Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice

Probing the molecular mechanism of interaction between polystyrene nanoplastics and catalase by multispectroscopic techniques

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