Colchicine for children with pericarditis: systematic review of clinical studies

Abstract

Abbreviations: Cochrane risk of bias tool for non-randomized trials (ACROBAT-NRSI), Creactive protein (CRP), electrocardiography (ECG), erythrocyte sedimentation rate (ESR), intravenous immunoglobulin (IVIG), non-steroidal anti-inflammatory drugs (NSAID), prospectively registered systematic reviews in health and social care (PROSPERO), 2 Contributors' Statement:Dr Alabed conceptualized and designed the review protocol, undertook data extraction and drafted the initial manuscript. He approved the final manuscript as submitted.Dr. Pérez-Gaxiola reviewed search strategy, undertook data extraction and gave comments on the draft manuscript. He approved the final manuscript as submitted.Dr. Burls checked the protocol, double checked the process and format of the review, and provided advice and feedback on the draft manuscript. She approved the final manuscript as submitted. 3 Abstract ObjectiveTo review the evidence for the efficacy and safety of colchicine in children with pericarditis.

Recurrent pericarditis as an extra‐intestinal manifestation of ulcerative colitis in a 14‐year‐old girl

“…The latter reduces symptoms and prevents recurrence . Colchicine (0.5 mg once a day if ≤5 years or 1.0–1.5 mg divided in 2–3 doses a day if >5 years) can prevent the recurrences up to 50% of cases without a significant risk of adverse events or intolerance . Finally, immunosuppressive drugs, such as azathioprine, anakinra, and cyclophosphamide, can be used in refractory, noninfectious cases requiring high‐dose corticosteroids .…”

Pericarditis y derrame pericárdico como presentación inicial de lupus eritematoso sistémico. Reporte de caso

“…La pericarditis aguda es una entidad clínica que puede evolucionar a derrame pericárdico cuando el líquido pericárdico supera los 50 mL 1 o incluso a taponamiento cardiaco si el derrame se instaura rápidamente, manifestado por la tríada de Beck (hipotensión, distensión de venas del cuello y ruidos cardiacos distantes). 6 El diagnóstico es clínico y eléctrico, basado en al menos dos de cuatro criterios: dolor torácico, frote pericárdico, anomalías electrocardiográfi cas com-patibles (elevación difusa del segmento ST con o sin onda T de corta duración, desnivel del segmento PR) o derrame pericárdico en ecocardiograma. 1,7,8 En países de bajos ingresos, donde entidades infecciosas como el virus de la inmunodefi ciencia humana o la tuberculosis son endémicas (por ejemplo, en poblaciones de la India y África), la principal causa de pericarditis es infecciosa.…”

“…1,3 Se ha reportado efi cacia de la colchicina en la prevención de recurrencias, sin embargo, existen pocos estudios y la evidencia para su recomendación es escasa y contradictoria en niños. 6,10 El uso de corticosteroides se recomienda en casos resistentes o recurrentes, en pericarditis urémica o enfermedades del tejido conectivo ha demostrado ser útil. 1 Existen otras alternativas de tratamiento en casos con recurrencia, como la pericardiectomía, agentes inmunosupresores (enfer- ximales de mano derecha medades del tejido conectivo) y anticuerpos monoclonales anti-IL1 (anakinra).…”

Colchicine for steroid-resistant recurrent pericarditis in a child

“…According to the European Society of Cardiology (ESC) guidelines, colchicine is considered an effective adjunctive drug to NSAIDs, rather than corticosteroids [8]. Even though colchicine is well tolerated in children, the evidence regarding its effects in children is still scarce and contradictory [9]. The recommended dose is 0.5mg/day for children less 5 years of age and 1.0-1.5mg/day those over 5 years old, and while recommended duration is 3 months for acute pericarditis and 6-12 months for recurrent pericarditis [10].…”