2016
DOI: 10.1136/archdischild-2015-310287
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Colchicine for children with pericarditis: systematic review of clinical studies

Abstract: Abbreviations: Cochrane risk of bias tool for non-randomized trials (ACROBAT-NRSI), Creactive protein (CRP), electrocardiography (ECG), erythrocyte sedimentation rate (ESR), intravenous immunoglobulin (IVIG), non-steroidal anti-inflammatory drugs (NSAID), prospectively registered systematic reviews in health and social care (PROSPERO), 2 Contributors' Statement:Dr Alabed conceptualized and designed the review protocol, undertook data extraction and drafted the initial manuscript. He approved the final manuscri… Show more

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Cited by 22 publications
(14 citation statements)
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“…The latter reduces symptoms and prevents recurrence . Colchicine (0.5 mg once a day if ≤5 years or 1.0–1.5 mg divided in 2–3 doses a day if >5 years) can prevent the recurrences up to 50% of cases without a significant risk of adverse events or intolerance . Finally, immunosuppressive drugs, such as azathioprine, anakinra, and cyclophosphamide, can be used in refractory, noninfectious cases requiring high‐dose corticosteroids .…”
Section: Discussionmentioning
confidence: 99%
“…The latter reduces symptoms and prevents recurrence . Colchicine (0.5 mg once a day if ≤5 years or 1.0–1.5 mg divided in 2–3 doses a day if >5 years) can prevent the recurrences up to 50% of cases without a significant risk of adverse events or intolerance . Finally, immunosuppressive drugs, such as azathioprine, anakinra, and cyclophosphamide, can be used in refractory, noninfectious cases requiring high‐dose corticosteroids .…”
Section: Discussionmentioning
confidence: 99%
“…La pericarditis aguda es una entidad clínica que puede evolucionar a derrame pericárdico cuando el líquido pericárdico supera los 50 mL 1 o incluso a taponamiento cardiaco si el derrame se instaura rápidamente, manifestado por la tríada de Beck (hipotensión, distensión de venas del cuello y ruidos cardiacos distantes). 6 El diagnóstico es clínico y eléctrico, basado en al menos dos de cuatro criterios: dolor torácico, frote pericárdico, anomalías electrocardiográfi cas com-patibles (elevación difusa del segmento ST con o sin onda T de corta duración, desnivel del segmento PR) o derrame pericárdico en ecocardiograma. 1,7,8 En países de bajos ingresos, donde entidades infecciosas como el virus de la inmunodefi ciencia humana o la tuberculosis son endémicas (por ejemplo, en poblaciones de la India y África), la principal causa de pericarditis es infecciosa.…”
Section: Discussionunclassified
“…1,3 Se ha reportado efi cacia de la colchicina en la prevención de recurrencias, sin embargo, existen pocos estudios y la evidencia para su recomendación es escasa y contradictoria en niños. 6,10 El uso de corticosteroides se recomienda en casos resistentes o recurrentes, en pericarditis urémica o enfermedades del tejido conectivo ha demostrado ser útil. 1 Existen otras alternativas de tratamiento en casos con recurrencia, como la pericardiectomía, agentes inmunosupresores (enfer- ximales de mano derecha medades del tejido conectivo) y anticuerpos monoclonales anti-IL1 (anakinra).…”
Section: Discussionunclassified
“…According to the European Society of Cardiology (ESC) guidelines, colchicine is considered an effective adjunctive drug to NSAIDs, rather than corticosteroids [8]. Even though colchicine is well tolerated in children, the evidence regarding its effects in children is still scarce and contradictory [9]. The recommended dose is 0.5mg/day for children less 5 years of age and 1.0-1.5mg/day those over 5 years old, and while recommended duration is 3 months for acute pericarditis and 6-12 months for recurrent pericarditis [10].…”
Section: Discussionmentioning
confidence: 99%