Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome

Aviel, Yonatan Butbul; Tatour, Sameh; Baruch, Ruth Gershoni; Brik, Riva

doi:10.1016/j.semarthrit.2015.07.005

Cited by 84 publications

(57 citation statements)

References 19 publications

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“…our survey found that corticosteroids were rated as "effective" or "very effective" by 95%, tonsillectomy by 68%, antypirectics by 29% and cimetidine or colchicine by 19%. There are, however, some retrospective studies reports suggesting that cimetidine and colchicine may prevent PFAPA flares in about 50% of children [20][21][22].…”

Section: Discussionmentioning

confidence: 98%

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Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Amarilyo

Rothman²,

Manthiram

et al. 2020

Pediatr Rheumatol

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Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. There is considerable heterogeneity in management strategies and a lack of evidence-based treatment guidelines. Consensus treatment plans (CTPs) are standardized treatment regimens that are derived based upon best available evidence and current treatment practices that are a way to enable comparative effectiveness studies to identify optimal therapy and are less costly to execute than randomized, double blind placebo controlled trials. The purpose of this project was to develop CTPs and response criteria for PFAPA.

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Section: Discussionmentioning

confidence: 98%

“…The prophylaxis arms were intended to examine the efficacy of cimetidine and colchicine, although there is limited evidence in the literature on their effectiveness [18,21,22]. While other drugs were candidates for prophylaxis (e.g.…”

Section: Discussionmentioning

confidence: 99%

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Amarilyo

Rothman²,

Manthiram

et al. 2020

Pediatr Rheumatol

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“…It has been considered as an effective prophylaxis, rather than as treatment for the periodic attacks in PFAPA syndrome, in a small number of studies with a limited number of patients. 6,27,28 Tasher et al 28 reported that colchicine treatment increased the between-episode interval in eight out of nine patients. Between-episode interval was significantly increased following colchicine treatment, from an average of 1.7 to 8.4 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…The rationale for colchicine prophylaxis in the present study was based on the clinical and laboratory similarities between these two very common autoinflammatory disorders in Turkey. It has been considered as an effective prophylaxis, rather than as treatment for the periodic attacks in PFAPA syndrome, in a small number of studies with a limited number of patients . Tasher et al .…”

Section: Discussionmentioning

confidence: 99%

Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?

Güneş

Çekiç

Kılıç

2017

Pediatrics International

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“…Geralmente, é bem tolerada pelos pacientes. 26,27,30 Aviel et al 27 um paciente apresentou resolução seis meses mais tarde, um permaneceu apresentando episódios febris e um foi diagnosticado com outra doença.…”

Section: Avaliação E Diagnósticounclassified

Síndrome PFAPA: Diagnóstico e Tratamento na Atenção Primária à Saúde

Bueno

Paiva

Carvalho

2019

Rev Bras Med Fam Comunidade

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Objetivo: Apresentar informações sobre o diagnóstico e tratamento da síndrome PFAPA na Atenção Primária à Saúde. Métodos: Revisão sistemática de literatura baseada na recomendação PRISMA e realizada nas bases de dados Scielo, Lilacs, Medline, IBECS e PubMed, incluindo estudos publicados no período de 2004 a 2018, além da consulta a outros documentos específicos da síndrome PFAPA. Resultados: Após busca e seleção, foram incluídos 31 artigos. Avaliação e Diagnóstico: A síndrome PFAPA acomete principalmente crianças, sendo caracterizada por febre periódica acompanhada por faringite, estomatite aftosa e/ou adenite cervical. Seu diagnóstico é clínico e por exclusão, baseado em critérios estabelecidos. Recomendações: Os episódios costumam responder a prednisona e, em graus variáveis, a cimetidina e colchicina. Casos refratários e acompanhados de hipertrofia tonsilar são candidatos a tonsilectomia, devendo ser encaminhados à avaliação otorrinolaringológica.

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Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome

Cited by 84 publications

References 19 publications

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?

Síndrome PFAPA: Diagnóstico e Tratamento na Atenção Primária à Saúde

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