COL5A1 may contribute the metastasis of lung adenocarcinoma

Liu, Weibo; Wei, Haifeng; Gao, Zheng-Yu; Chen, Guanghui; Liu, Yujie; Gào, Xīn; Bai, Guangjian; He, Shaohui; Liu, Tielong; Xu, Wei; Yang, Xianghong; Jiao, Jian; Xiao, Jianru

doi:10.1016/j.gene.2018.04.066

Cited by 76 publications

(63 citation statements)

References 40 publications

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Section: Discussionmentioning

confidence: 73%

“…Accordingly, increased expression of COL5A1 in tumor tissues may participate in cell growth of TSCC . Moreover, cancer cells silenced with siRNA against COL5A1 showed reduced cell invasion, demonstrating the association of higher COL5A1 expression with metastasis in many tumors including our TSCC patients . Previous studies showed that low expression of miR‐145 is associated with cell proliferation and migration in a wide variety of tumors and co‐expression of higher COL5A1 and low miR‐145 was detected in primary meningioma tissues, representing an indirect effect on COL5A1 transcriptional regulation .…”

Section: Discussionmentioning

confidence: 77%

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Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma

Chen

Tseng

Shu

et al. 2019

J Oral Pathology Medicine

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Background Type V collagen (COL5), in the functional heterotrimer [α1(V)2α2(V)] isoform, participates in the malignancies of various cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear. Materials and Methods The expression levels of COL5A1 and COL5A2 polypeptide chains were examined using the tissue microarray from 245 TSCC patients with immunohistochemistry. Paired t test and Wilcoxon signed‐rank test were performed for comparisons among the groups. Survival rates were estimated by using the Kaplan‐Meier method and compared with log‐rank tests. A Cox proportional hazards model was used to evaluate the impact of protein expression level on survival rate. Results Expression level of COL5A1 was significantly increased in tumor tissues (P < 0.001) compared to that in corresponding adjacent normal tissues. High expression level of COL5A1 was associated with advanced pathological stage (III, IV, P = 0.015) and lymph node metastasis (P = 0.005) of TSCC patients. High expression level of COL5A1 was also correlated with poor disease‐specific survival (DSS, P = 0.001) and disease‐free survival (DFS, P = 0.003) in TSCC patients. However, high expression level of COL5A2 was correlated with better DFS in TSCC patients (P = 0.043). Moreover, co‐expression level of high (COL5A1)2/low (COL5A2) heterotrimer was correlated with worse DSS (P = 0.004) and DFS (P = 0.004). Conclusion COL5A1 is an unfavorable factor for tumorigenesis, clinicopathological outcomes, and prognosis, whereas COL5A2 is only a favorable factor for prognosis in TSCC. The co‐expression of high (COL5A1)2/low (COL5A2) heterotrimer is a more potential unfavorable factor for prognosis in TSCC.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 77%

Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma

Chen

Tseng

Shu

et al. 2019

J Oral Pathology Medicine

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“…COL5A1 (Collagen type V α1 chain) encoded an alpha chain for one of the low abundance fibrillar collagens, whose high expression could contribute to tumor progression. [34][35][36] COL5A1 is highly immunogenic, 37 and decreased and abnormal synthesis of collagen type V α1 chain was found associated with immune response and endothelial death in cancer microenvironment. 38 Besides, collagens were expressed in stromal cell fibroblasts and high levels of some collagens (e.g.…”

Section: Discussionmentioning

confidence: 99%

The new identified biomarkers determine sensitivity to immune check-point blockade therapies in melanoma

et al. 2019

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Immune checkpoint blockade (ICB) therapy has achieved remarkable clinical benefit in melanoma. However, our understanding of biomarkers that predict response to ICB remained obscure. Here we systematically analyzed the association between somatic mutations profile and clinicopathologic information from 336 melanoma patients treated by ICB (CTLA-4/PD-1). We identified eight new significantly mutated genes including COL5A1, SEMA3E, COL28A1, DGKG, RAPGEF5, GLDN, NCF2 and RCAN2. A mutational signature featured by enrichment of T > C mutations was identified to be associated with immune resistance (logistic regression model, OR, 2.59 [95%CI, 1.07 to 7.00], P = .043). High neoantigen quality was associated with prolonged immunotherapy survival (log-rank test, P = .009). This association remained significant after controlling for age, gender, stage and hypermutation (Cox proportional hazards model, HR, 0.56 [95%CI, 0.38 to 0.82], P = .003). Our findings shed new insights on biomarkers that are useful to predict melanoma patients who may benefit from ICB treatment; however, these biomarkers need to be validated in future studies. ARTICLE HISTORY

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“…Extracellular matrix-receptor interaction is the pathway involved in lung adenocarcinoma, gastric cancer, and so on. 18,19 As reported, the increased activation of unfolded protein responses mediators in the ER in different tumor types patients and their upregulation usually related to poor prognosis and resistibility to many kinds of treatments. 20 Mechanistic data have indicated that ribosome biosynthesis disorders have a broader effect in most spontaneous cancers progression and development.…”

Section: Discussionmentioning

confidence: 95%

Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis

Cao

Liu

et al. 2020

Dose-Response

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Background: The risk of malignant transformation of enchondromas (EC) toward central chondrosarcoma is increased up to 35%, while the exact etiology of EC is unknown. The purpose of this research was to authenticate gene signatures during EC and reveal their potential mechanisms in occurrence and development of EC. Methods: The gene expression profiles was acquired from Gene Expression Omnibus database (no. GSE22855). The gene ontology (GO), protein–protein interaction (PPI) network and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were utilized to identify differentially expressed genes (DEGs). Results: Finally, 242 DEGs were appraisal, containing 200 overregulated genes and 42 downregulated genes. The outcomes of GO analysis indicated that upregulated DEGs were mainly enriched in several biological processes containing response to hypoxia, calcium ion, and negative regulation extrinsic apoptotic signaling pathway. Furthermore, the upregulated DEGs were enriched in extracellular matrix (ECM)–receptor interaction, protein processing in endoplasmic reticulum and ribosome, which was analyzed by KEGG pathway. From the PPI network, the top 10 hub genes were identified, which were related to significant pathways containing ribosome, protein processing in endoplasmic reticulum, and ECM-receptor interaction. Conclusion: In conclusion, the present study may be helpful for understanding the diagnostic biomarkers of EC.

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COL5A1 may contribute the metastasis of lung adenocarcinoma

Cited by 76 publications

References 40 publications

Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma

Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma

The new identified biomarkers determine sensitivity to immune check-point blockade therapies in melanoma

Identification of Key Genes and Pathways for Enchondromas by Bioinformatics Analysis

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