COL11A1 in FAP polyps and in sporadic colorectal tumors

Fischer, Håkan; Salahshor, Sima; Stenling, Roger; Björk, Jan; Lindmark, Gunilla; Iselius, Lennart; Rubio, Carlos A.; Lindblom, Annika

doi:10.1186/1471-2407-1-17

Cited by 53 publications

(48 citation statements)

References 17 publications

(22 reference statements)

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“…2). These data are consistent with a study which found a correlation between Col11a1 expression in colorectal carcinoma and an activated β-catenin-Lef1/Tcf pathway (Fischer et al, 2001). Analysis of the Col11a1 promoter identified at least six potential Lef1 binding sites, but only two were found to bind Lef1 in vitro (data not shown).…”

Section: Discussionsupporting

confidence: 91%

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation

et al. 2008

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Section: Discussionsupporting

confidence: 91%

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation

et al. 2008

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“…Intense 125 I-ET-1 binding once again correlated with both fibroblast and endothelial cell staining. Collagen type XI (Col XI), which was used to further define tumor stroma, was only present in tumor sections and not normal tissue, confirming previous reports of its association with colorectal pathology (20,21).…”

Section: Efficacy Of Zibotentan In In Vitro Models Of Colorectal Cancersupporting

confidence: 59%

Efficacy of the Specific Endothelin A Receptor Antagonist Zibotentan (ZD4054) in Colorectal Cancer: A Preclinical Study

Haque

Dashwood

Heetun

et al. 2013

Molecular Cancer Therapeutics

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Endothelin 1 (ET-1) is overexpressed in cancer, contributing to disease progression. We previously showed that ET-1 stimulated proliferative, migratory, and contractile tumorigenic effects via the ET A receptor. Here, for the first time, we evaluate zibotentan, a specific ET A receptor antagonist, in the setting of colorectal cancer, in cellular models. Pharmacologic characteristics were further determined in patient tissues. Colorectal cancer lines (n ¼ 4) and fibroblast strains (n ¼ 6), isolated from uninvolved areas of colorectal cancer specimens, were exposed to ET-1 and/or ET A/B receptor antagonists. Proliferation (methylene blue), migration (scratch wounds), and contraction (gel lattices) were assessed. Receptor distribution and binding characteristics (K d , B max ) were determined using autoradiography on tissue sections and homogenates and cytospun cells, supported by immunohistochemistry. Proliferation was inhibited by ET A (zibotentan > BQ123; P < 0.

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“…Genes associated with Wnt/β-catenin signalling pathway: Both CDH11 and COL11A1 are associated with the Wnt/β-catenin signalling pathway [54,55,56]. We have found that treatment of PC3 cells with Ganoderma ethanol-based extracts caused a significant increase in the expression of CDH11.…”

Section: Genes Associated With Cell Cycle Controlmentioning

confidence: 89%

A comparison of the gene expression profiles and pathway network analyses after treatment of Prostate cancer cell lines with different Ganoderma lucidum based extracts

Kao

Bishop

Han

et al. 2014

FFHD

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Background: Ganoderma lucidum is a type of fungus commonly consumed in Asia for the promotion of health and longevity. The observed biological activity of G. lucidum includes anti-cancer and anti-inflammatory effects which may be useful in the treatment and prevention of cancer and other chronic diseases. G. lucidum grows under conditions which range from tropical to temperate and has a different physiology depending on the geographical region in which it is grown. For this reason, the health benefits may vary depending on the form of G. lucidum and the environmental conditions to which it was exposed. This led us to investigate the effect of wildly grown G. lucidum, from the Himalayan region versus other commercially available G. lucidum products, on two human cancer cell lines.Methods: Extraction of the bioactive components found in G. lucidum is essential, as the fungus is tough and indigestible. Four different Ganoderma extracts were prepared. Thereafter, the extracts were tested on two human prostate cancer cell lines, and the IC 50 s were determined. This was followed by the use of Affymetrix GeneChip® PrimeView™ Human Gene Expression Arrays to identify the changes in gene expression due to the treatment of prostate cancer cell lines (PC3 and DU145) with Ganoderma extracts. Several key genes identified with Affymetrix analysis were validated using RT-PCR. Results and Discussion:We found that all the Ganoderma extracts showed growth inhibition in the cancer cell lines tested. Using Affymetrix microarray analysis, we identified four main biologically active pathways: cell cycle control/apoptosis, cell-cell adhesion, DNA repair, and inflammatory /immune response, where activity was influenced by the Ganoderma extracts used. Using RT-PCR, we tested ten genes associated with all four pathways. The RT-PCR results supported our findings in the Affymetrix analysis, i.e. that G. lucidum extracts have an anti-inflammatory and cell cycle effect and therefore may have long term health benefits. These effects were specific to the extract tested.

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COL11A1 in FAP polyps and in sporadic colorectal tumors

Cited by 53 publications

References 17 publications

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation

Efficacy of the Specific Endothelin A Receptor Antagonist Zibotentan (ZD4054) in Colorectal Cancer: A Preclinical Study

A comparison of the gene expression profiles and pathway network analyses after treatment of Prostate cancer cell lines with different Ganoderma lucidum based extracts

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