Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice

Zhou, Qilyu; Yu, Ruyang; Liu, Tianlong; Li, Yeye; Zhong, Jia; Zhang, Tao; Liu, Zhongjie; Hu, Yusheng

doi:10.3390/nu14010123

Cited by 19 publications

(10 citation statements)

References 23 publications

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“…CSE has a protective effect on intestinal mucosal immunity, helps to repair the intestinal barrier, and promotes the transmission of hypoglycemic signaling pathways. In a study on the protective effect of CSE on colitis mucosa, T cell regulation was one of the targets of CSE ( 47 , 48 ), reducing the oxidative stress level in the intestine, reducing the secretion of TNF-α in the intestinal mucosa, and protecting the intestinal mucosa ( 47 , 49 ). Research on blood sugar regulation of type 2 diabetes by CSE found that CSE can reduce colonic mucosal damage, increase serum insulin levels and increase HLDL levels to control blood sugar.…”

Section: Discussionmentioning

confidence: 99%

Effects of Coix Seed Extract, Bifidobacterium BPL1, and Their Combination on the Glycolipid Metabolism in Obese Mice

Zhang

Jia

et al. 2022

Front. Nutr.

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Coix seed extract (CSE) and probiotics have been reported to regulate glycolipid metabolism via different modes of action. We tested the effects of CSE, Bifidobacterium BPL1, and their combination to determine their effects on glycolipid metabolism in obese mice. Male C57BL/6J mice were fed a high-fat diet for 8 weeks to establish an obesity model. Obese mice were selected and divided into four groups: the model control group and three intervention groups. After 10 weeks of continuous gavage intervention, the mice in the intervention groups exhibited lower body weight (lower about 2.31 g, vs. HFD mice 42.23 g) and epididymal (lower about 0.37 g, vs. HFD mice 2.5 g) and perirenal fat content (lower about 0.47 g, vs. HFD mice 0.884 g); decreased fasting blood glucose, total cholesterol, triglycerides, and VLDL; and increased HLDL, respiratory exchange ratio, energy expenditure, and amount of exercise performed. CSE, BPL1 and their combination can effectively control the weight gain in obese mice, reduce fat content, and regulate blood lipids and abnormal blood sugar. These results may be related to reduce the chronic inflammatory states, improve energy metabolism, exercise, relieve insulin sensitivity, and reduce lipid synthesis via the intervention of CSE, BPL1 and their combination. Compared with the single use of CSE alone, the combination of CSE + BPL1 can better exert the regulation function of intestinal flora, and change in the abundance of bacteria that could improve the level of inflammatory factors, such as increasing Bifidobacterium, reducing Lactococcus. Compared with the use of BPL1 alone, the combination of CSE and BPL1 can better regulate pancreatic islet and improve blood sugar. CSE may act directly on body tissues to exert anti-inflammatory effects. BPL1 and CSE + BPL1 may improve the structure and function of the intestinal flora, and reduce tissue inflammation.

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Section: Discussionmentioning

confidence: 99%

Effects of Coix Seed Extract, Bifidobacterium BPL1, and Their Combination on the Glycolipid Metabolism in Obese Mice

Zhang

Jia

et al. 2022

Front. Nutr.

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“…[ 9 ] The current results indicate that CHRNA7-Ca 2+ -PI3K-PIP3-AKT-(MTOR, NFk β , BIRC5) is a key target signaling pathway of the activity of active components in coix seed for treatment of CRC. Zhou et al [ 6 ] reported that injection of coix seed oil effectively reduced the pain level of cancer patients. Previous findings and the results of this study indicate that the analgesic mechanism of coix seed active compounds may be associated with targeting of the neuroactive ligand-receptor interaction the signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…of CRC. Zhou et al [6] reported that injection of coix seed oil effectively reduced the pain level of cancer patients. Previous findings and the results of this study indicate that the analgesic mechanism of coix seed active compounds may be associated with targeting of the neuroactive ligand-receptor interaction the signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…The main active components in coix seed include unsaturated fatty acids, steroids, esters, polysaccharides, and triterpenes [ 5 ]. Zhou et al [ 6 ] reported that coix seed alleviates experimental colitis in mice through immunoregulation activity. Jinnouchi et al [ 7 ] indicated that coix seed modulates the function of the human immune system by regulating the intestinal microflora.…”

Section: Introductionmentioning

confidence: 99%

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Network Pharmacology-Based Analysis of the Potential Biological Mechanisms of Coix Seed against Colorectal Cancer

Sun

Jiang

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study was to explore the potential biological mechanisms of coix seed in the treatment of colorectal cancer (CRC) based on network pharmacology analysis. Methods. The active components of coix seed and their potential action targets were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP). The disease targets related to CRC were obtained from the DisGeNET database. The intersection targets of the drug targets and disease targets were selected, and a component-target-disease network was built using Cytoscape 3.8.0 tool. A global network of the core target protein interactions was constructed using String database. Biological function analysis and pathway enrichment analysis of core targets were conducted to explore the potential. Results. A total of nine active components were obtained from the TCMSP database corresponding to 37 targets. Further analysis showed that 18 overlapping targets were associated with CRC. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was conducted based on the 18 targets and 11 significantly enriched signaling pathways implicated in CRC were identified. Conclusion. The multicomponent and multitarget characteristics of coix seed are preliminarily verified, and the potential biological mechanisms of coix seed in the treatment of CRC are predicted, which provides a theoretical basis for the experimental research.

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“…Clinical trials have confirmed that Coix seed has the effect of relieving ulcerative colitis. By acting on important targets such as T-cell regulation, the Coix seed feed can maintain the complete blood count at a normal level, relieve oxidative stress, reduce inflammatory cytokine secretion and pathological score, and finally relieve the symptoms of colitis ( Zhou et al, 2021b ). Gu et al (2020a ) combined network pharmacology technology with GEO gene chips and found that oral administration of Indigo naturalis (IN) could hinder the further development of ulcerative colitis, and the specific therapeutic effect may involve the activation of systemic immunity, mainly acting on the JAK-STAT and IL-17 signaling pathways.…”

Section: Application Of Network Pharmacology In the Treatment Of Ulce...mentioning

confidence: 99%

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review

et al. 2022

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Network pharmacology is a research method based on a multidisciplinary holistic analysis of biological systems, which coincides with the idea of the holistic view of traditional Chinese medicine. In this review, we summarized the use of network pharmacology technology through studying Chinese medicine single medicine or Chinese medicine compound research ideas and methods for the treatment of ulcerative colitis, based on the application of the current network pharmacology in Chinese medicine research, including the important role in the mechanism of the prediction and verification, to search for new ideas for disease diagnosis and treatment, this study summarizes the application of network pharmacology in the treatment of ulcerative colitis in traditional Chinese medicine, including monotherapy and compound therapy, and considers that relevant research studies have fully demonstrated the function characteristics of the multi-component, multi-target, and multi-pathway of traditional Chinese medicine, and can also explain the connotation of “selecting appropriate treatment methods according to the differences and similarities of pathogenesis” of traditional Chinese medicine. Finally, we raised important questions about the prospects and limitations of network pharmacology, such as differences caused by different data collection methods, a considerable lag, and so on.

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Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice

Cited by 19 publications

References 23 publications

Effects of Coix Seed Extract, Bifidobacterium BPL1, and Their Combination on the Glycolipid Metabolism in Obese Mice

Effects of Coix Seed Extract, Bifidobacterium BPL1, and Their Combination on the Glycolipid Metabolism in Obese Mice

Network Pharmacology-Based Analysis of the Potential Biological Mechanisms of Coix Seed against Colorectal Cancer

Application of network pharmacology in the study of mechanism of Chinese medicine in the treatment of ulcerative colitis: A review

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