Coinfection of Cytomegalovirus (Immunoglobulin G) Antibody in Anti-hepatitis C Virus Seropositive Cases at a Tertiary Care Hospital

Abstract

Context: Cytomegalovirus (CMV) infection enhances hepatitis C virus (HCV) pathogenesis as it prevents the normal mechanisms which are responsible for HCV clearance, thus plays a key role in HCV persistence and pathogenicity. Aims: An individual develops lifetime CMV (immunoglobulin G [IgG]) seropositivity, after primary infection after which CMV establishes latency with intermittent reactivation. Thus, the present study was undertaken to look for coinfection of CMV (IgG) in HCV seropositive cases in the hospital.