Coincident presence of thyro-gastric autoimmunity at onset of Type 1 (insulin-dependent) diabetes

Riley, William J.; Winer, Aaron; Goldstein, David L.

doi:10.1007/bf00257339

Cited by 33 publications

(8 citation statements)

References 13 publications

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“…The prevalence of TMA among Type 2 diabetic patients was not significantly higher than in their non-diabetic counterparts. Riley et al reported that the frequency of TMA shows a major increase after the fifth decade of life [10]. The diabetic patients in this study were significantly older than the control subjects; despite that, they did not have a significantly higher frequency of TMA.…”

Section: Discussioncontrasting

confidence: 49%

Thyroid autoimmunity in Type 2 (non-insulin-dependent) diabetic patients of Caucasoid, black and Mexican origin

Kasim

Bessman

1984

Diabetologia

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Summary. Four hundred and forty-nine patients with Type 2(non-insulin-dependent) diabetes mellitus and 270 control subjects from Caucasoid, Mexican and black origins were screened for the presence of thyroid microsomal antibodies. Mexican female control subjects had a significantly higher frequency of thyroid microsomal antibodies when compared with black female controls (21% versus 6%, p < 0.01). Type2 diabetic patients did not have a higher frequency of thyroid microsomal antibodies when compared with their sex-and race-matched control counterparts. The subgroup of diabetic patients who required insulin for the control of their blood glucose did not have a higher frequency of thyroid microsomal antibodies when compared with non-insulin-requiting diabetic patients. In conclusion autoimmunity against thyroid gland, as manifested by thyroid microsomal antibodies, is not more common in Type 2 diabetic patients when compared with sex-and race-matched control subjects.

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Section: Discussioncontrasting

confidence: 49%

Thyroid autoimmunity in Type 2 (non-insulin-dependent) diabetic patients of Caucasoid, black and Mexican origin

Kasim

Bessman

1984

Diabetologia

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“…This prevalence of ICA was slightly higher than reported in other studies on Caucasian and Japanese patients (37)(38)(39). This increased positivity percentage could be explained by use of a more sensitive assay and also perhaps by the time chosen for screening: the subjects were all sampled at the time hyperthyroidism was diagnosed, when autoimmunity phenomena were not only active, but perhaps enhanced (40).…”

Section: Discussionmentioning

confidence: 51%

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients

Maugendre¹,

Verite²,

Guilhem³

et al. 1997

European Journal of Endocrinology

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The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among subjects at risk of diabetes.Ten were already diabetic at GD diagnosis. Among the 590 non-diabetic patients, 29 had islet cell antibodies (ICA), including 15 with low titre ICA and only 1 ICA-positive subject with a familial history of diabetes. Twenty-four patients had insulin autoantibodies, including three in association with ICA. Glutamic acid decarboxylase (GAD)/64 kDa antibodies were found in 16 of the 150 tested sera, including 13 of the 29 ICA-positive sera. Four ICA-positive patients displayed 37/40 kDa antibodies, including three in association with GAD/64 kDa antibodies. During follow-up, one of the ICA-positive patients developed insulin-dependent diabetes, 14 years after the GD diagnosis.To summarize, this anti-pancreatic autoimmunity study was focused on a large but specific and homogeneous group of subjects at risk for diabetes: recently diagnosed GD patients. This population was characterized by a high prevalence of GAD/64 kDa antibodies but also by a low frequency of evolution towards diabetes and the slowness of the process which could be due to the fact that only a minority of subjects possessed a sufficient combination of anti-pancreatic markers at the same time.

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“…In a previous study, however, we found by both cross-sectional and longitudinal observations of children with IDDM that in the large majority of cases thyroid and gastric autoantibodies had usually appeared by the time of onset of IDDM, with few patients developing these antibodies at a later time. 16 In an expanded cross-sectional series of the patients (Table 1), modest and nonsignificant increases in the frequencies of these autoantibodies could be seen as the follow-up period was extended beyond 10 yr after diagnosis of IDDM (Figure 2), especially in the female patients. Whereas such a late increase of frequencies of thyroid and gastric autoantibodies in patients with IDDM may reflect the trend of the general population as a whole, it is possible that in most cases autoimmune disorders involving pancreatic islets and thyroid and gastric mucosa occur simultaneously, albeit these diseases have different natural histories.…”

Section: Effect Of Age Of Onset and Duration Of Iddm On Occurrence Ofmentioning

confidence: 92%

Thyroid, Gastric, and Adrenal Autoimmunities Associated with Insulin-dependent Diabetes Mellitus

Maclaren

Riley

1985

Diabetes Care

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Thyroid microsomal, gastric parietal, and adrenocortical autoantibodies were sought in 1456 Caucasian and 240 black patients with insulin-dependent diabetes mellitus (IDDM), in 1467 of the Caucasian patients' immediate family members, and in 1519 normal Caucasian control subjects. Positive clinical significances and predictive values of these autoantibodies for associated gland dysfunctions were found. In all groups, thyroid and gastric autoantibodies were more common in female subjects. In the control group, thyroid and gastric autoantibodies were more frequent with advancing age, affecting more than one-third of Caucasian women after age 60 yr. This age-augmented increase occurred very prematurely in patients with IDDM and their relatives. Among the patients with IDDM and thyroid and gastric autoantibodies, these autoantibodies appeared by the time of onset of IDDM in the large majority of cases; however, they were more common among patients with later ages of onset of IDDM. Occurrence of thyroid and gastric autoantibodies in 404 siblings of patients with IDDM was not affected by their degree of HLA-haplotype sharing with their diabetic sibling, suggesting that the inherited predisposition to thyroid and gastric autoimmunity is not HLA-related. In light of this, the increased frequencies of these antibodies in patients with IDDM and their relatives suggest that "thyroid and gastric autoimmunity genes" may also predispose to IDDM.

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Coincident presence of thyro-gastric autoimmunity at onset of Type 1 (insulin-dependent) diabetes

Cited by 33 publications

References 13 publications

Thyroid autoimmunity in Type 2 (non-insulin-dependent) diabetic patients of Caucasoid, black and Mexican origin

Thyroid autoimmunity in Type 2 (non-insulin-dependent) diabetic patients of Caucasoid, black and Mexican origin

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients

Thyroid, Gastric, and Adrenal Autoimmunities Associated with Insulin-dependent Diabetes Mellitus

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