Coincident basophilic chronic myelogenous leukemia and pulmonary tuberculosis. Associated with extreme elevations of blood histamine levels and maturity onset asthma

Shohet, Stephen B.; Blum, Stuart F.

doi:10.1002/1097-0142(196807)22:1<173::aid-cncr2820220121>3.0.co;2-f

Cited by 11 publications

(3 citation statements)

References 2 publications

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“…7 But without such a treatment, occurrence of TB in patient with CML is an uncommon entity and rare cases were reported. [12][13][14] Silva et al in a large retrospective study found only one case of TB among 45 CML cases. 11 In our patient, peritoneal TB was diagnosed first and haematological parameters initially gave us an impression of leukamoid reaction, but the initial bone marrow examination failed to identify any granuloma, AFB or malignancy and subsequently, within the next two weeks the typical picture of CML became obvious.…”

Section: Discussionmentioning

confidence: 98%

“…[3][4][5][6][7] TB can complicate acute leukaemias and lymphomas, but concomitant diagnosis of TB and CML is an uncommon entity. [8][9][10][11][12][13][14] Case report A 52-year-old diabetic lady presented with one month history of low grade, intermittent fever and gradual abdominal distension for two weeks. She did not have any cough, haemoptysis, night sweats, jaundice, leg swelling, chest pain, palpitation, joint pain or weight loss.…”

Section: Introductionmentioning

confidence: 99%

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Peritoneal Tuberculosis in a Patient with Chronic Myeloid Leukemia and Diabetes Mellitus: A Diagnostic Dilemma

et al. 2013

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Tuberculosis (TB) may complicate patients with chronic myeloid leukaemia (CML) receiving imatinib mesylate, but concomitant diagnosis of TB and CML is rare. Here, we present a middle aged Bangladeshi diabetic lady who got admitted because of prolonged pyrexia, ascites and splenomegaly. Diagnostic workup confirmed peritoneal TB and CML. Being an uncommon entity, we are reporting the case. Birdem Med J 2013; 3(2): 113-115 DOI: http://dx.doi.org/10.3329/birdem.v3i2.17217

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Peritoneal Tuberculosis in a Patient with Chronic Myeloid Leukemia and Diabetes Mellitus: A Diagnostic Dilemma

et al. 2013

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“…However, a higher dose increases the risk of drug side effects, which can reduce patient adherence. The relationship between CML and TB has been reported in only anecdotal case observations . The largest CML case series published to date reports the cases of only three patients who developed active TB after a median of 17 months of imatinib therapy .…”

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confidence: 99%

Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population‐based study in Taiwan

Liu

Hong

Teng

et al. 2014

Intl Journal of Cancer

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The relationship between chronic myeloid leukemia (CML) and tuberculosis (TB) has not been determined. We conducted a national survey including 1,082 CML patients identified from the Taiwan National Health Insurance database covering a period between 1998 and 2011; the matched non-exposed cohort included 10,820 subjects without CML that were matched for age, sex and comorbidities. The impact of TB was measured by the overall mortality, and the risk factors were identified by a multivariate Cox proportional hazards model. We found the risk of TB was higher in the CML cohort, with an adjusted hazard ratio (aHR) of 3.76 (p 5 0.001) for both pulmonary (aHR 3.23, p < 0.001) and extrapulmonary (aHR 9.77, p 5 0.001) TB. Specific risk factors were: aged 60 (aHR 3.24, p 5 0.022), being male (aHR 13.49, p 5 0.012), receiving stem cell transplantation (aHR 10.50, p 5 0.001) and interferon-a therapy (aHR 3.34, p 5 0.011). CML patients with TB had a higher mortality rate than those without (aHR 2.04, p 5 0.043). We conclude that the incidence of TB is significantly higher in CML patients of male sex, aged 60, having received either stem cell transplantation or interferon-a treatment. Careful screening strategies for TB should be considered for CML patients with high risk of the infection.

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Histamine contents of blood plasma and cells in patients with myelogenous leukemia

Suzuki

Ishida

Kono

et al. 1971

Cancer

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Twenty‐three pairs of fluorometric measurements of histamine were made on blood plasma and cells from patients with acute (10 cases) and chronic myelogenous leukemia (13 cases). The mean histamine level of plasma of patients (17.6 ± 10.5 μ/L) exceeded that of normal subjects (7.6 ± 4.7 μg/L). None of the patients complained of any symptoms referable to the agent. The ratio of mean histamine level of cells from a liter of blood to that of a liter of plasma was higher in patients with chronic (2410 to 19.6) and acute leukemia (213 to 15.0) than in normal subjects (51.2 to 7.6). A significant correlation between histamine levels of cells (Y) and counts of basophils (X) was ascertained. It was expressed in a regression curve: Y = 33.1 X0.486. This suggested that the higher the basophil count, the lower histamine per cell. On blood histamine in leukemia with increased basophil count, the following were discussed: why increased plasma histamine did not yield symptoms, and how the agent is dealt with when released from cells in vivo.

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Coincident basophilic chronic myelogenous leukemia and pulmonary tuberculosis. Associated with extreme elevations of blood histamine levels and maturity onset asthma

Cited by 11 publications

References 2 publications

Peritoneal Tuberculosis in a Patient with Chronic Myeloid Leukemia and Diabetes Mellitus: A Diagnostic Dilemma

Peritoneal Tuberculosis in a Patient with Chronic Myeloid Leukemia and Diabetes Mellitus: A Diagnostic Dilemma

Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population‐based study in Taiwan

Histamine contents of blood plasma and cells in patients with myelogenous leukemia

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