Coincidence of primary myelodysplastic syndrome and non-Hodgkin lymphoma

Abstract

A 60-year-old patient is presented with primary myelodysplastic syndrome classified according to the criteria of the French-American-British classification as chronic myelomonocytic leukemia and with a hyperviscosity syndrome. We found a monoclonal gammopathy with a very high serum immunoglobulin M level. There is strong evidence for coincidence of myelodysplastic syndrome and Waldenström's macroglobulinemia in this patient.

Multiple lymphoid nodules in bone marrow have the same clonality as underlying myelodysplastic syndrome recognized with fluorescent in situ hybridization technique

“…The coexistence of MDS with a lymphoid or plasmacytic neoplasm has been reported [15][16][17][18], but the incidence is low in comparison with the lymphoid aggregates found in about 8% of cases with myelodysplasia [2]. The results of clonal studies in MDS are still equivocal; some suggest that the pluripotent stem cell is affected in MDS and others suggest that the lymphoid progenitor is not involved because the lymphoid cells usually do not express the abnormal karyotype [19][20][21][22][23].…”

Plasmalymphacytapheresis in the treatment of cold autoimmune hemolytic anemia

“…Improvement of symptoms in our patient, marked by improved respiration and lack of further bleeding, which occurred after therapeutic plasmapheresis, indicate that the symptoms were indeed caused by hyperviscosity. A single case of myelodysplastic syndrome with a coexistent monoclonal gammopathy and secondary H V S has been reported [6]. However, there are no cases reported in the literature of myelodysplastic syndrome with polyclonal gammopathy and HVS, as in our patient.…”

Chronic myelomonocytic leukemia preceding high‐grade immunoblastic lymphoma

“…To the Editor: Chronic myelomonocytic leukemia (CMML) is a relatively uncommon type of myelodysplastic syndrome. The association of CMML and lymphoid neoplasia has been reported but is extremely rare (1)(2)(3)(4). We report a patient who developed a highgrade immunoblastic lymphoma 6 months after being diagnosed as suffering from CMML.…”

“…This patient presented with typical features of CMML and 6 months later developed stage IV highgrade immunoblastic lymphoma. On reviewing the literature we found some reports showing association of CMML and myeloma or low-grade lymphoid malignancy (1)(2)(3)(4). To our knowledge, an association of CMML and an aggressive lymphoma has not yet been reported.…”