Coincidence of late‐onset cytomegalovirus‐induced myositis and gastritis in a pediatric renal transplant recipient

Abstract

An 8-year-old girl with a renal transplant was admitted for myalgia and muscle weakness in both legs over the previous 2 weeks. She also had fever and intermittent epigastric pain. Based on these clinical manifestations, and laboratory and histopathological findings, the diagnosis was coincidence of late-onset cytomegalovirus (CMV)-induced myositis and gastritis in an immunocompromised child with a renal transplant. After administration of intravenous ganciclovir for 3 weeks, her symptoms resolved, with normalization of abnormal muscle enzymes, including lactate dehydrogenase, creatine kinase, aspartate aminotransferase, and the disappearance of CMV viremia.

Human cytomegalovirus‐related gastrointestinal disease after kidney transplantation: A systematic review

“…Overall, details on hCMV‐specific anti‐viral therapy were reported in 139/311 (44.7%) cases. According to the information collected, 112 patients were administered ganciclovir monotherapy, 27,83 six valganciclovir monotherapy, 25,29,31,50 and 18 a sequential combination of both drugs 23,24,30,36,41,44,45,51,59,60,62,63,66,74 . Three KTRs did not receive anti‐viral therapy 35,68 .…”

“…According to the information collected, 112 patients were administered ganciclovir monotherapy, 27,83 six valganciclovir monotherapy, 25,29,31,50 and 18 a sequential combination of both drugs. 23,24,30,36,41,44,45,51,59,60,62,63,66,74 Three KTRs did not receive anti-viral therapy. 35,68 The duration of ganciclovir and valganciclovir administration ranged from 14 to 35 days and from 21 to 30 days, respectively.…”

“…Cyclosporin 15,22,27,28,[30][31][32]38,41,46,54,56,58,60,64,68,[70][71][72][73][74] 34 MMF 15,16,22,[24][25][26][27][28]30,31,36,40,41,43,45,50,51,[54][55][56]57,59,61,62,65,70,72,74 85 Azathioprine Colitis [14][15][16][17]…”