Coincidence of juvenile idiopathic arthritis and type 1 diabetes: a case-based review

Szabłowski, Maciej; Okruszko, Michał Andrzej; Pochodowicz, Katarzyna; Abramowicz, Paweł; Konstantynowicz, Jerzy; Bossowski, Artur; Głowińska-Olszewska, Barbara

doi:10.1007/s00296-021-05083-z

Cited by 10 publications

(4 citation statements)

References 47 publications

(50 reference statements)

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“…For instance, a case-control study demonstrated that each IQR increase in PFOA exposure was associated with a 69% increase in the risk of RA [ 30 ]. Moreover, individuals with arthritis are more susceptible to diabetes and other metabolic diseases [ 11 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES

Yang,

Li,

Jiang

2024

BMC Public Health

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Whether a family history of diabetes (FHD) and exposure to perfluoroalkyl acids (PFAAs) are correlated with an increased risk of developing arthritis remains unclear. This cross-sectional study was conducted to explore the correlations between FHD or exposure to PFAAs and arthritis as well as their interaction using the National Health and Nutrition Examination Survey (NHANES). In total, 6,194 participants aged ≥ 20 years from the 2011–2018 NHANES were enrolled. PFAAs are a cluster of synthetic chemicals, including perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorodecanoic acid (PFDA) and perfluorohexane sulfonic acid (PFHxS). FHD was evaluated using self-reported questionnaires. Arthritis was classified into three types, rheumatoid arthritis (RA), osteoarthritis (OA), and others, which were diagnosed using questionnaires. Generalized linear models (GLMs) were used to test the correlation between FHD and arthritis. To examine the joint effects of PFAAs and FHD on arthritis, interaction terms were applied in the GLM. Arthritis incidence was 26.7% among all participants. FHD was associated with both RA [OR = 1.70 (95% CI: 1.15–2.50)] and other types of arthritis [OR = 1.62 (95% CI: 1.21–2.16)]. However, the relationship between FHD and OA was not significant after adjustment (P = 0.18). Interaction outcomes indicated that higher PFDA levels increased the association between FHD and arthritis. FHD is associated with an increased incidence of arthritis, which may be increased by PFDA. Given the heavy burden of arthritis, preventive measures for arthritis and reduction of PFAAs exposure for patients with FHD are required.

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Section: Discussionmentioning

confidence: 99%

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES

Yang,

Li,

Jiang

2024

BMC Public Health

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“…Genetic variations of genes that cause T-cell dysfunction (e.g., HLA, CTLA4, and PTPN22) may be involved in the development of these conditions [91]. On the other hand, diabetes may be facilitated by the adverse effects of frequent corticosteroid use on JIA flairs [92].…”

Section: T1d and Other Aidsmentioning

confidence: 99%

“…Hence, the immune-modulatory effect may have a role in preventing the immune cascade responsible for the onset of T1D, suggesting that an earlier start of these effective drugs may have a protective effect on beta cell preservation. Moreover, the use of disease-modifying antirheumatic drugs has been associated with a significant improvement in HbA1c and a reduced need for insulin [92], hence these therapies in JIA may impact the risk of developing T1D and/or improve T1D disease course [95][96][97][98][99].…”

Section: T1d and Other Aidsmentioning

confidence: 99%

Type 1 Diabetes and Other Autoimmune Disorders in Children

Grasso,

Chiarelli

2024

Pediatric Diabetes

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The incidence of autoimmune disorders (AIDs) has been dramatically increasing in both children and adults over the past few years, and type 1 diabetes (T1D) is one of the diseases that has seen the highest growth. It is well-known that the dysimmune process may spread to other systems, leading to the onset of one or more AIDs in the same individual; however, the relationship between AIDs is not often recognized. The most frequently diagnosed AIDs in children and adolescents with T1D are thyroid diseases and celiac disease, but it is also important to consider the onset of the other conditions, such as juvenile idiopathic arthritis, multiple sclerosis, atrophic gastritis, inflammatory bowel diseases, and skin disorders such as vitiligo and psoriasis. This review aims to explore the overlap of T1D and other AIDs, focusing on the less common and lesser-known diseases. A better knowledge of these comorbidities may facilitate the identification of patients at risk to treat them in the preclinical period, before the onset of complications.

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“…There are variability in the prevalence of adolescent T1DM with the highest incidence of T1DM reported in the United States (US), India and Brazil 4 . There is a huge economic burden from the chronic nature of the disease due to its multiple short and long-term complications, presenting it as a global health crisis to handle 5 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of closed-loop control system for type one diabetes in adolescents a meta analysis

Jabari

2023

Sci Rep

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This meta-analysis compares the efficacy and safety of Closed-Loop Control (CLC) to Sensor-Augmented Insulin Pump (SAP) for adolescent patients with Type 1 Diabetes Mellitus (T1DM). Eleven randomized-controlled trials were included with a total of 570 patients, from a total of 869 articles found adhering to PRISMA guidelines. The efficacy of the therapies were evaluated from the day, night and during physical activities monitoring of the of the mean blood glucose (BG), Time In Range (TIR), and Standard Deviation (SD) of the glucose variability. The safety measure of the therapies, was assessed from the day and night recording of the hypoglycemic and hyperglycemic events occurred. Pooled results of comparison of mean BG values for day, night and physical activities, − 4.33 [− 6.70, − 1.96] (P = 0.0003), − 16.61 [− 31.68, − 1.54] (P = 0.03) and − 8.27 [− 19.52, 2.99] (P = 0.15). The monitoring for day, night and physical activities for TIR − 13.18 [− 19.18, − 7.17] (P < 0.0001), − 15.36 [− 26.81, − 3.92] (P = 0.009) and − 7.39 [− 17.65, 2.87] (P = 0.16). The day and night results of SD of glucose variability was − 0.40 [− 0.79, − 0.00] (P = 0.05) and − 0.86 [− 2.67, 0.95] (P = 0.35). These values shows the superiority of CLC system in terms of efficacy. The safety evaluation, of the day, night and physical activities observations of average blood glucose goal hypoglycemic events − 0.54 [− 1.86, 0.79] (P = 0.43), 0.04 [− 0.20, 0.27] (P = 0.77) and 0.00 [− 0.25, 0.25] (P = 1.00) and hyperglycemic events − 0.04 [− 0.20, 0.27] (P = 0.77), − 7.11 [− 12.77, − 1.45] (P = 0.01) and − 0.00 [− 0.10, 0.10] (P = 0.97), highlights the commendable safety factor of CLC. The CLC systems can be considered as an ideal preference in the management of adolescents with type 1 diabetes to be used during a 24 h basis.

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Coincidence of juvenile idiopathic arthritis and type 1 diabetes: a case-based review

Cited by 10 publications

References 47 publications

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011–2018 NHANES

Type 1 Diabetes and Other Autoimmune Disorders in Children

Efficacy and safety of closed-loop control system for type one diabetes in adolescents a meta analysis

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