Coils and tubes releasing heparin. Studies on a new vascular graft prototype

Aldenhoff, Yvette B. J.; Knetsch, Menno L. W.; Hanssen, Johannes H L; Lindhout, Théo; Wielders, Simone J.H.; Koole, Léo H.

doi:10.1016/j.biomaterials.2003.10.012

Cited by 29 publications

(40 citation statements)

References 20 publications

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“…Each spiral provides a three-dimensional surface; each polymer is present as a smooth uniform coating on the coiled wire. Inclusion of heparin in the coating results in a greatly increased thrombo-resistance of the surface [16]. It was not so much the release, but the surface exposure of heparin that improved the haemo-compatibility of the spirals.…”

Section: Introductionmentioning

confidence: 95%

The effect of high-density-lipoprotein on thrombus formation on and endothelial cell attachement to biomaterial surfaces

2006

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Section: Introductionmentioning

confidence: 95%

The effect of high-density-lipoprotein on thrombus formation on and endothelial cell attachement to biomaterial surfaces

2006

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“…The choice for this biomaterial was based on our previous experience that these copolymers feature excellent biocompatibility, e.g., in contact with blood, ocular epithelium, and bone. 2,13,18,23 The coated mesh was compared in a series of experiments in vivo (using a rat model) with the uncoated Prolene Ò and coated Proceed Ò mesh (Ethicon, Johnson & Johnson, Somerville, NJ, USA). The latter is a three-layer composite of a PP mesh, an absorbable layer of oxidized regenerated cellulose, and an intermediate layer of polydioxanone.…”

Section: Introductionmentioning

confidence: 99%

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

et al. 2008

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Abstract-Abdominal surgery is associated with a significant risk for incisional herniation. Hernia repair is routinely performed by implantation of synthetic meshes. Such meshes may cause serious adhesions between the implanted material and organs leading to intestinal obstruction or enterocutaneous fistulas. This study compares three knitted meshes for their capacity to prevent adhesion formation in an in vivo study. The meshes evaluated are polypropylene (Prolene Ò ), polypropylene coated with oxygenated regenerated cellulose-in principle-a biodegradable biomaterial (Proceed Ò ), and Prolene Ò coated with a nondegradable copolymer of the hydrophilic building block N-vinyl pyrrolidone (NVP) and the hydrophobic building block n-butylmethacrylate (BMA). The meshes were implanted in the abdomen of rats (followup 7 or 30 days). After 7 days, the formation of adhesions decreased in the order: Prolene Ò > NVP/BMA-coated Prolene Ò > Proceed Ò ; after 30 days, this order changed into: Proceed Ò > Prolene Ò > NVP/BMA-coated Prolene Ò . Both at 7 and at 30 days, Proceed Ò was the only mesh surrounded by macrophage cells that contained foreign materials, presumably degradation products of the (biodegradable) surface coating. The data indicate that long-term protection of implanted meshes against excessive adhesions may be achieved through stable biocompatible hydrogel surface coatings.

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“…The procedure afforded hard, opaque materials. The most hydrophilic copolymer had a NVP/BMA ratio of 90/10, the most hydrophobic one a ratio of 10/90 [21,22].…”

Section: Polymersmentioning

confidence: 99%

“…This apparatus consists of a small mixing chamber (approximately 8 ll) with one outlet and two inlet ports [21]. Blood from a healthy donor was obtained through venipuncture, and was collected on sodium citrate (13 mM final).…”

Section: Thrombin Generationmentioning

confidence: 99%

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A novel synthetic vascular prosthesis: effect of plasma protein adsorption on blood‐ and cyto‐compatibility

Knetsch¹,

Aldenhoff

Hanssen³

et al. 2006

Materialwissenschaft Werkst

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The development of a genuinely functional small diameter vascular prosthesis remains one of the toughest problems in biomedical engineering. Most current small diameter vascular grafts fail because of thrombotic complications or neo-intimal hyperplasia. Here were present a novel synthetic vascular prosthesis with a polymer coated luminal surface. The coating can be tuned for its hydrophilicity by varying the molar ratio of the monomers, N-vinylpyrrolidinone and butyl-methacrylate. Additionally these polymeric coatings can be loaded with anticoagulant drugs, like heparin. Especially surface exposed heparin dramatically improved bloodcompatibility of the coating, reducing thrombin generation. For long-term functionality of vascular prostheses, formation of an endothelial cell layer is vital. In vitro, the hydrophobic coatings in particular supported formation of an endothelial cell layer. Upon adsorption of blood plasma proteins, endothelial cells grew equally well on all surfaces, irrespective of the hydrophilicity. It was found that high density lipoprotein (HDL) is responsible for transforming hydrophilic coatings into good cell-compatible surfaces. Furthermore, HDL can reduce surface-induced thrombin generation and therefore can be used to modify the lumen of a vascular prosthesis.Keywords

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Coils and tubes releasing heparin. Studies on a new vascular graft prototype

Cited by 29 publications

References 20 publications

The effect of high-density-lipoprotein on thrombus formation on and endothelial cell attachement to biomaterial surfaces

The effect of high-density-lipoprotein on thrombus formation on and endothelial cell attachement to biomaterial surfaces

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

A novel synthetic vascular prosthesis: effect of plasma protein adsorption on blood‐ and cyto‐compatibility

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