Coil–Globule Transition of a Water-Soluble Polymer

Liu, Jianyu; Guo, Huazhang; Gao, Qingjie; Li, Hongbin; An, Zesheng; Zhang, Wenke

doi:10.1021/acs.macromol.2c01039

Cited by 5 publications

(7 citation statements)

References 46 publications

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“…The VPTT of D‐MPNN hydrogel is similar to that of PNN‐II hydrogel (Figure 2b), suggesting that adding MXene and Dex in small amounts does not affect the coil‐to‐globule transition of PNN. [ 30 ] The photothermal conversion performance and Dex release of D‐MPNN hydrogel were measured in a simulated cell culture environment using phosphate‐buffered saline (PBS) as a medium. The temperature of the medium increases with increasing laser power, and the temperature could be maintained at ≈42 °C upon a laser power of 0.030 W cm −2 (Figure 2c).…”

Section: Resultsmentioning

confidence: 99%

Superior Synergistic Osteogenesis of MXene‐Based Hydrogel through Supersensitive Drug Release at Mild Heat

Chen,

Liu,

Wan

et al. 2023

Adv Funct Materials

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Near‐infrared (NIR) responsive smart drug delivery systems could provide efficient osteogenesis through the synergy of heat and drugs. However, such systems are hampered by an inability to allow supersensitive drug release through mild heat. Here superior osteogenesis is demonstrated using a biocompatible dexamethasone (Dex)‐loaded MXene‐poly(N‐isopropylacrylamide)‐co‐N‐(Hydroxymethyl) acrylamide hydrogel capable of the supersensitive release of Dex at ≈42 °C upon NIR irradiation. Furthermore, the hydrogel can significantly promote bone regeneration under NIR irradiation due to the synergistic anti‐apoptosis and osteogenic differentiation of bone‐derived mesenchymal stem cells induced by the mild heat and supersensitive release of Dex. The resulting osteogenesis efficiency of hydrogels surpass efficiencies previously reported for heat and drug stimulation and their combination. The synergistic osteogenesis strategy is characterized by near‐instantaneous, noninvasive, and precise treatment through temporal NIR irradiation.

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Section: Resultsmentioning

confidence: 99%

Superior Synergistic Osteogenesis of MXene‐Based Hydrogel through Supersensitive Drug Release at Mild Heat

Chen,

Liu,

Wan

et al. 2023

Adv Funct Materials

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“…Liu et al offer a representative approach using MT to gain insight into the kinetic and dynamic behavior of polymer regime transitions. 57 They employed poly(N-isopropylacrylamide), PNIPAM, as a model system, subjecting it to isothermal stretching and relaxation under static force to investigate the coilÀglobule transition mechanism (Figure 6A). The PNIPAM polymer was synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization using a 4-cyano-4-(ethylthiocarbonothioylthio)pentanoic acid chain-transfer agent (CTA), which introduced thioylthio and carboxyl ends to each side of PNIPAM.…”

Section: Detecting the Dynamic Change Of Conformationmentioning

confidence: 99%

“…Liu et al offer a representative approach using MT to gain insight into the kinetic and dynamic behavior of polymer regime transitions 57 . They employed poly(N‐isopropylacrylamide), PNIPAM, as a model system, subjecting it to isothermal stretching and relaxation under static force to investigate the coil−globule transition mechanism (Figure 6A).…”

Section: Magnetic Tweezers For Studying Synthetic Polymersmentioning

confidence: 99%

“…Dynamic changes of regime in poly(N‐isopropylacrylamide) (PNIPAM) 57 . (A) Schematic representation illustrating the application of magnetic tweezers (MT) in analyzing the regime transition of PNIPAM.…”

Section: Magnetic Tweezers For Studying Synthetic Polymersmentioning

confidence: 99%

Section: Magnetic Tweezers For Studying Synthetic Polymersmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of single synthetic polymers via magnetic tweezers

Xie,

Zhou,

Mao

et al. 2023

Journal of Polymer Science

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Due to the ability to perform the parallel measurement of multiple single chains and exert precise control over stretching force in the sub‐nanonewton regime, magnetic tweezers (MT) are a suitable tool to study the individual chain conformations and inherent behaviors of polymers. Herein, we examined the applications of MT in studying single synthetic polymers, distinct from previous reviews focusing on biological polymers such as DNAs. We first presented an overview of the technical aspects of MT, including the imaging setup, the algorithm of three‐dimensional single particle tracking, the configuration of magnets, the calibration and control of magnetic forces, the assembly of flow cells, and the polymer tethering methods. Then, we discussed selected examples highlighting the utilization of MT in studying the chain conformation, mechanical properties, ion and ligands effect, regime transition mechanism, and polymerization dynamics of single synthetic polymers. We envision that MT can serve as a powerful toolbox for delving into the structure–property correlations at the single chain level, which provides quantitative validations for building the theoretical models of synthetic polymers. In the end, we contemplated potential avenues and opportunities for future research in this domain.

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Single-Molecule Study Reveals Ion-Dependent Conformational Change and Nanomechanical Property of Crown Ether-Based Polymer

Liu,

Yao,

Sun

et al. 2024

Macromolecules

Self Cite

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The host−guest recognition of crown ethers and alkali metal ions plays a key role in many functional systems. The understanding of the static conformation of the crown ether ring and guest ion is steadily growing, but little is known about the dynamic response of the complex structure when the crown ether ring is deformed. In this study, we successfully monitored the conformational changes of the host−guest complex formed by poly(dibenzo-18-crown-6) and metal ions through single-molecule force spectroscopy and constrained geometry simulated external force calculations. A distinctive shoulder-like force plateau can be observed on the force−extension curve, which depends on both the cation and anion species. Quantum chemical calculations revealed that during the conformation change, the number of coordination bonds between the oxygen atoms on the ring and K + ions were dynamically changed from six to four with an intermediate bond number of two, and K + was gradually squeezed out of the center of the crown ether ring. In addition, the size of the alkali metal ions was found to greatly affect its deformation pathway. This study deepened our understanding of crown ether-based host−guest interactions in a brand-new vision. And, it is useful for tuning the properties of crown ether-based functional materials because the DB18C6 unit can be easily incorporated into the network of polymer materials. Furthermore, such a method can be used to explore and tune the host−guest interactions in other macrocyclebased systems.

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Coil–Globule Transition of a Water-Soluble Polymer

Cited by 5 publications

References 46 publications

Superior Synergistic Osteogenesis of MXene‐Based Hydrogel through Supersensitive Drug Release at Mild Heat

Superior Synergistic Osteogenesis of MXene‐Based Hydrogel through Supersensitive Drug Release at Mild Heat

Characterization of single synthetic polymers via magnetic tweezers

Single-Molecule Study Reveals Ion-Dependent Conformational Change and Nanomechanical Property of Crown Ether-Based Polymer

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