Cohort study protocol to characterize the incidence and severity of neuropathic pain in patients with severe acute respiratory syndrome coronavirus 2 infection

Odozor, Chioma U; Roles, Kristen; Burk, Carrie; Kannampallil, Thomas; Clifford, David B.; Piccirillo, Jay F.; Haroutounian, Simon

doi:10.1097/pr9.0000000000000925

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…The protocol for this observational cohort study was approved by the institutional review board of the Washington University in St. Louis School of Medicine (IRB# 202004043) and published. 19…”

Section: Methodsmentioning

confidence: 99%

“…The novel coronavirus, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), and the resulting coronavirus disease 2019 (COVID- 19) have caused approximately 200 million confirmed cases globally, with 4.2 million deaths as of August 2021 29 Emerging data indicate that post-acute sequelae of COVID-19 persist among a subset of patients, predominantly reported as fatigue, headaches, anosmia, tachycardia, memory impairment, and peripheral neuropathy symptoms. 25,26 Several viral infections have been associated with painful peripheral neuropathy complications, 7,11,13,14,24,28 which are typically associated with pain and anatomically overlapping sensory disturbances such as paresthesias, most often in a distal symmetric (acral) distribution.…”

Section: Introductionmentioning

confidence: 99%

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Post-acute sensory neurological sequelae in patients with severe acute respiratory syndrome coronavirus 2 infection: the COVID-PN observational cohort study

Odozor

Kannampallil

Abdallah

et al. 2022

Pain

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Post-acute sensory neurological sequelae in patients with severe acute respiratory syndrome coronavirus 2 infection: the COVID-PN observational cohort study

Odozor

Kannampallil

Abdallah

et al. 2022

Pain

Self Cite

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“…COVID‐19 has been associated with acute and chronic pain in the general population [5, 6]; in patients with SCD, acute pain is reportedly the most common presenting symptom of COVID‐19 [7]. COVID‐19 may cause peripheral and central neurological complications [8–10], including neuropathic pain (NP), not unlike other viral infections [11–14]. Pain from vaso‐occlusive crisis (VOC) and acute chest syndrome (ACS) as presenting symptoms of COVID‐19 infection, and increased frequency and severity of VOC pain crises after COVID‐19 infection have been reported [2, 7, 15–19].…”

Section: Introductionmentioning

confidence: 99%

COVID‐19 infection and pain in adolescents with sickle cell disease: A case series

Heyman

Alberts

Rees

et al. 2022

eJHaem

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Adolescents with sickle cell disease (SCD) have been shown to have pain-related sequelae following COVID-19 infection. In this case series, we discuss five adolescents with SCD and SARS-CoV-2 infection who subsequently developed complex pain circumstances manifested as: (1) increased frequency of acute care visits or admissions for pain; (2) new onset chronic pain; (3) new onset neuropathic pain; (4) escalation in the complexity of pharmacologic therapies; (5) increased use of nonpharmacologic interventions. While more research is needed to fully understand the implications of COVID-19 infection on pain in adolescents with SCD, these cases suggest the presence of a complex relationship. K E Y W O R D S anemia, chronic pain, COVID-19, neuropathic pain, sickle cell disease, vaso-occlusive crisis 1 19 [7]. COVID-19 may cause peripheral and central neurological complications [8-10], including neuropathic pain (NP), not unlike other viral infections [11-14]. Pain from vaso-occlusive crisis This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…In addition, despite a certain possibility of nervous system involvement by COVID-19, little is known about the impact of COVID-19 on the severity or characteristics of preexisting neuropathic pain [ 17 ]. Based on the results of these studies, a large-scale cohort study is underway to investigate the incidence and severity of neuralgia in COVID-19 patients [ 18 ].…”

mentioning

confidence: 99%

Transition of COVID-19 to endemic phase and emergence of COVID-19 related neuropathic pain

Choi

2022

Korean J Pain

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Coronavirus disease 2019 (COVID-19) has caused several million deaths since it was first reported in December 2019 [1]. From the beginning of the COVID-19 pandemic, the main concern has been related to its acute respiratory involvement which may need ICU hospitalization and could lead to death. Since peaking in January 2022, new cases have continued to decline around the world. Gradually, extrapulmonary manifestations and post-COVID-19 syndrome have attracted more attention [2]. One of these is pain, one of the most common symptoms in the acute phase even after recovery from COVID-19.Acute pain during COVID-19 does not seem significantly different from most viral diseases, and myalgia and headache are the main symptoms, while anosmia and ageusia occurs more frequently [3]. Many of these have been managed with symptomatic treatments such as painkillers and anti-inflammatory drugs, but some patients suffer from pain that lasts more than four weeks, which is regarded as one of the post-COVID-19 syndromes [4]. In fact, symptoms in the acute phase, such as headache, anosmia and ageusia, could be recognized as a neurological manifestation.

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Cohort study protocol to characterize the incidence and severity of neuropathic pain in patients with severe acute respiratory syndrome coronavirus 2 infection

Abstract: Supplemental Digital Content is Available in the Text. In this protocol for a cohort study, an approach to characterize new-onset or worsening neuropathic pain in patients with COVID-19 is described.

Cited by 8 publications

References 25 publications

Post-acute sensory neurological sequelae in patients with severe acute respiratory syndrome coronavirus 2 infection: the COVID-PN observational cohort study

Post-acute sensory neurological sequelae in patients with severe acute respiratory syndrome coronavirus 2 infection: the COVID-PN observational cohort study

COVID‐19 infection and pain in adolescents with sickle cell disease: A case series

Transition of COVID-19 to endemic phase and emergence of COVID-19 related neuropathic pain

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