Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology

Tanabe, Sean; Bo, Amber Y.; White, Marissa; Parker, Margaret; Farahbakhsh, Zahra; Ballweg, Tyler; Casey, Cameron; Betthauser, Tobey J.; Zetterberg, Henrik; Blennow, Kaj; Christian, Brad T.; Bendlin, Barbara B.; Johnson, Sterling C.; Sanders, Robert D.

doi:10.1093/braincomms/fcaa099

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Their results revealed that theta activity in fronto-central regions was higher in tau/neuroinflammation-positive patients. Consistent findings across studies also highlight that both β-amyloid and tau/neuroinflammation were associated with slowing of brain rhythm activity in aging (Tanabe et al, 2020). Here we replicated the association for theta daily fluctuations only with tau/neuroinflammation, which would indicate that tau is associated with different features of theta brain rhythms.…”

Section: Distinct Theta and Gamma Association With Ad Pathological Ma...supporting

confidence: 86%

Daily dynamics of resting-state EEG theta and gamma fluctuations are associated with cognitive performance in healthy aging

Bennis,

Eustache,

Collette

et al. 2023

Preprint

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Healthy age-related cognitive changes are highly heterogeneous across individuals. This variability is increasingly explained through the lens of spontaneous fluctuations of brain activity, now considered as powerful index of age-related changes. However, brain activity is a biological process modulated by circadian rhythms, and how these fluctuations evolve throughout the day is under investigated. Assessing the daily dynamics of brain fluctuations involves the use of techniques measuring the temporal dynamics of synchronized communications between brain regions, such as electroencephalography. We found that theta and gamma daily fluctuations in the salience-control executive inter-network (SN-CEN) are associated with distinct mechanisms underlying cognitive heterogeneity in aging. Higher levels of SN-CEN theta daily fluctuations appear to be deleterious for memory performance and were associated with higher tau/neuroinflammation rates. In contrast, higher levels of gamma daily fluctuations are positively associated with executive performance, and were associated with lower rate of β-amyloid deposition. Thus, accounting for daily EEG fluctuations of brain activity contributes to better understand subtle brain changes underlying individuals’ cognitive performance in healthy aging.

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Section: Distinct Theta and Gamma Association With Ad Pathological Ma...supporting

confidence: 86%

Daily dynamics of resting-state EEG theta and gamma fluctuations are associated with cognitive performance in healthy aging

Bennis,

Eustache,

Collette

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…The study was approved by the University of Wisconsin-Madison Institutional Review Board and all participants provided informed consent. Participants volunteered for resting state 14 and roving oddball auditory stimulation collection of EEG data.…”

Section: Methodsmentioning

confidence: 99%

“…An a priori sample size was not conducted, as these data were collected as part of a study that also collected resting state EEG that is already published. 14 All available data from the cohort study were included in this work.…”

Section: Methodsmentioning

confidence: 99%

Greater tau pathology is associated with altered predictive coding

Gjini

Casey

Tanabe

et al. 2022

Brain Communications

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Altered predictive coding may underlie the reduced auditory mismatch negativity amplitude observed in patients with dementia. We hypothesized that accumulating dementia-associated pathologies, including amyloid and tau, lead to disturbed predictions of our sensory environment. This would manifest as increased reliance on “observed” sensory information with an associated increase in feedforward, and decrease in feedback, signaling. To test this hypothesis, we studied a cross-sectional cohort of participants who underwent positron emission tomography imaging and high-density EEG during an odd-ball paradigm, and used dynamic casual modeling and Bayesian statistics to make inferences about the neuronal architectures (generators) and mechanisms (effective connectivity) underlying the observed auditory evoked responses. Amyloid-β imaging with [C-11] Pittsburgh Compound-B PET were qualitatively rated using established criteria. Tau-positive PET scans, with [F-18]MK6240, were defined by a MK-6240 standardized uptake value ratio positivity threshold at two standard deviations above the mean of the Amyloid(−) group in the entorhinal cortex (entorhinal MK-6240 SUVR > 1.27). The cross-sectional cohort included a total of 56 participants (9 and 13 participants in the Tau(+) and Amyloid(+) subgroups, respectively: age interquartile range of [73.50 - 75.34] and [70.5–75.34] years, 56% and 69% females, respectively; 46 and 43 participants in the Tau(-) and Amyloid(-) subgroups, respectively: age interquartile range of [62.72–72.5] and [62.64–72.48] years, 67% and 65% females, respectively). Mismatch negativity amplitudes were significantly smaller in Tau+ subgroup than Tau- subgroup (cluster statistics corrected for multiple comparisons: p = 0.028). Dynamic causal modelling showed that tau pathology was associated with increased feedforward connectivity and decreased feedback connectivity, with increased excitability of superior temporal gyrus but not inferior frontal regions. This effect on superior temporal gyrus was consistent with the distribution of tau disease on PET in these participants, indicating that the observed differences in mismatch negativity reflect pathological changes evolving in preclinical dementia. Exclusion of participants with diagnosed mild cognitive impairment or dementia did not affect the results. These observational data provide proof of concept that abnormalities in predictive coding may be detected in the preclinical phase of Alzheimer’s disease. This framework also provides a construct to understand how progressive impairments lead to loss of orientation to the sensory world in dementia. Based on our modeling results, plus animal models indicating that Alzheimer’s disease pathologies produce hyperexcitability of higher cortical regions through local disinhibition, mismatch negativity might be a useful monitor to deploy as strategies that target interneuron dysfunction are developed.

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“…Similar network alternations associated with biofluid markers have been put forward. For example, increased CSF p- and t-tau levels were correlated with EEG slowing and decreasing synchronization in patients with cognitive impairment ( Smailovic et al, 2018 ; Tanabe et al, 2020 ); the combined p-tau/Aβ42 ratio exhibited a stronger correlation with the slow-frequency band in elderly individuals ( Stomrud et al, 2010 ). Beyond plasma t-tau, we also found some specific correlations between other plasma biomarkers (NfL and α-syn) and EEG parameters in individual band power.…”

Section: Discussionmentioning

confidence: 99%

Association of Plasma and Electroencephalography Markers With Motor Subtypes of Parkinson’s Disease

Yang

Li²,

Bai³

et al. 2022

Front. Aging Neurosci.

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ObjectiveThe aim of this study was to investigate the correlations of plasma neurodegenerative proteins and electroencephalography (EEG) dynamic functional network (DFN) parameters with disease progression in early Parkinson’s disease (PD) with different motor subtypes, including tremor-dominant (TD) and postural instability and gait disorder (PIGD).MethodsIn our study, 33 patients with PD (21 TD and 12 PIGD) and 33 healthy controls (HCs) were enrolled. Plasma neurofilament light chain (NfL), α-synuclein (α-syn), total-tau (t-tau), β-amyloid 42 (Aβ42), and β-amyloid 40 (Aβ40) levels were measured using an ultrasensitive single-molecule array (Simoa) immunoassay. All the patients with PD underwent EEG quantified by DFN analysis. The motor and non-motor performances were evaluated by a series of clinical assessments. Subsequently, a correlation analysis of plasma biomarkers and EEG measures with clinical scales was conducted.ResultsIn the TD group, plasma NfL exhibited a significant association with MDS-UPDRS III and Montreal Cognitive Assessment (MoCA). A higher Aβ42/40 level was significantly related to a decrease in Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) in the PIGD group. In terms of the correlation between EEG characteristic parameters and clinical outcomes, trapping time (TT) delta was positively correlated with MDS-UPDRS III and MoCA scores in the TD group, especially in the prefrontal and frontal regions. For other non-motor symptoms, there were significant direct associations of kPLI theta with HAMD and HAMA, especially in the prefrontal region, and kPLI gamma was particularly correlated with Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire (RBDSQ) scores in the prefrontal, frontal, and parietal regions in the TD group. Furthermore, there was a significant positive correlation between plasma t-tau and kPLI, and pairwise correlations were found among plasma NfL, theta TT, and MoCA scores in the TD group.ConclusionThese results provide evidence that plasma neurodegenerative proteins and EEG measures have great potential in predicting the disease progression of PD subtypes, especially for the TD subtype. A combination of these two kinds of markers may have a superposition effect on monitoring and estimating the prognosis of PD subtypes and deserves further research in larger, follow-up PD cohorts.

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Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology

Cited by 9 publications

References 29 publications

Daily dynamics of resting-state EEG theta and gamma fluctuations are associated with cognitive performance in healthy aging

Daily dynamics of resting-state EEG theta and gamma fluctuations are associated with cognitive performance in healthy aging

Greater tau pathology is associated with altered predictive coding

Association of Plasma and Electroencephalography Markers With Motor Subtypes of Parkinson’s Disease

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