Cohort Study Analysis with a FORTRAN Computer Program

Coleman, Michel P; Douglas, A. J.; Hermon, C; Peto, Julian

doi:10.1093/ije/15.1.134

Cited by 241 publications

(107 citation statements)

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“…Standard mortality ratios are calculated as recommended in the literature (5,6). The reference death rates are published by the INSERM, at the national or regional level (95 French districts).…”

Section: Case-contol Studiesmentioning

confidence: 99%

Occupational Cancer in France: Epidemiology, Toxicology, Prevention, and Compensation

Aubrun¹,

Binet²,

Bozec³

et al. 1999

Environmental Health Perspectives

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This article is a description of the current situation in France with regard to occupational cancer: research, prevention, and occupation. Toxicologic experiments are carried out using in vitro and in vivo tests, particularly using transgenic mice. Several epidemiologic studies have been conducted over the last decades: population-based case-control studies; mortality studies and cancer incidence studies carried out in historical cohorts of workers employed in the industry; and case-control studies nested in occupational cohorts. French ethical aspects of toxicologic and epidemiologic studies are described. The results thus obtained are used to establish regulations for the prevention and the compensation of cancers attributable to occupational exposure. This French regulation for prevention of occupational cancer involves several partners: a) the states authorities, including labor inspectors, responsible for preparing and implementing the labor legislation and for supervising its application, particularly in the fields of occupational health and safety and working conditions; b) the Social Security Organisation for the analysis of present or potential occupational risks based on tests, visits in plants, complaints or requests from various sources, and statistics. These activities are performed within the framework of the general French policy for the prevention of occupational cancer. This organization includes the National Institute for Research and Safety, particularly involved in research in the various fields of occupational risks-animal toxicology, biologic monitoring, exposure measurements epidemiology, psychology, ergonomy, electronic systems and machineries, exposure to chemicals, noise, heat, vibration, and lighting; and c) companies where the regulation defines the role of the plant manager, the occupational physician, and the Health, Safety and Working Conditions Committee (comprising the manager, employees' representatives, the occupational physician, and the safety department) in dealing with any problem regarding safety, occupational hygiene, and working conditions. These organizations along with medical practitioners are involved with the compensation of occupational cancers. The regulation for compensation includes the tables of occupational cancer, the possibility of recognition of a cancer case when the requirements of the tables are not met, and the postprofessional follow-up of workers exposed to a carcinogenic agent. -Environ Health Perspect 107(Suppl 2): 245-252 (1999). http.//ehpnetl.niehs.nih.gov/docs/1999/Suppl-21245-252aubrun/abstract.html

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Section: Case-contol Studiesmentioning

confidence: 99%

Occupational Cancer in France: Epidemiology, Toxicology, Prevention, and Compensation

Aubrun¹,

Binet²,

Bozec³

et al. 1999

Environmental Health Perspectives

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“…The number of person-years experienced by the cohort was calculated in 5-year intervals of age and calendar time (Coleman et al, 1986 …”

Section: Analysesmentioning

confidence: 99%

Cancer morbidity in alcohol abusers

Tønnesen¹,

Møller²,

Andersen³

et al. 1994

Br J Cancer

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Summary Data on the association between alcohol abuse and cancer morbidity are scarce in large cohorts of non-hospitalised alcoholic men and women. Of 18,368 alcohol abusers who entered an outpatient clinic in Copenhagen during 18,307 were followed and their cancer incidence was compared with that of the total Danish population. On average the 15,214 men were observed for 12.9 years and the 3,093 women for 9.4 years. The overall morbidity of cancer was increased significantly. Of the men, 1,441 developed cancer [relative risk (RR) = 1.6; 95% confidence interval (CI) = 1.5-1.7], while 182 women did (RR = 1.5; 95% CI 1.3-1.8).Significantly increased incidences were found of cancer in the tongue, mouth, pharynx, oesophagus, liver, larynx, lung and pleura and secondary cancer. The women had significantly increased risk of cervical cancer (RR = 2.0; 95% CI 1.2-3.0). The men developed prostatic cancer significantly more frequently than expected (RR = 1.4; 95% CI 1.2-1.8). The risk of melanomas (RR = 0.5; 95% CI 0.2-0.8) was significantly lower than expected. The relative risks of cancer of the stomach, pancreas, kidney and endocrine system were only slightly increased. The study group did not develop more colonic (RR = 1.0; 95% CI 0.8-1.3) or rectal cancer (RR = 1.0; CI 0.7-1.3) than expected. The risk of breast cancer in women was slightly increased (RR = 1.3; 95% CI 0.9-1.7), but not statistically significant. Thus, the associations between alcohol and cancer of the upper digestive and respiratory tract and the liver are confirmed. In addition, this study indicates an increased occurrence of cancer of the prostate gland, pleura and uterine cervix in alcohol abusers.

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“…The statistical significance of any excess of second tumours was derived by assuming the observed number to be drawn from a Poisson distribution with mean equal to the expected number: tests were onesided, in the direction of the observed difference. These calculations were done separately for index tumours diagnosed in the 1960s and the 1970s, using the program PYRS (Coleman et al, 1986). Ninety per cent confidence intervals for the RR were calculated (Rothman & Boice, 1982 (Table I).…”

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confidence: 99%

Second primary malignancy after Hodgkin's disease, ovarian cancer and cancer of the testis: A population-based cohort study

Coleman

Bell²,

Fraser³

1987

Br J Cancer

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Summary The risk of second primary malignancy was assessed in a population-based cohort study of all persons registered with Hodgkin's disease (n = 2,970), ovarian cancer (n = 1 1,802) and testicular cancer (n =2,013) in the South Thames Cancer Registry during the period 1961-80, to identify for further study those second malignancies which might be treatment-related.A total of 244 second malignancies was observed. After adjustment for age, sex and calendar period, the relative risk of any second malignancy was 1.4 (90% confidence interval (CI) 1.1-1.7) after Hodgkin's disease, 1.1 (90% CI 1.0-1.2) after ovarian cancer and 0.7 (90% CI 0.5-1.0) after testicular cancer. In particular, the relative risk for leukaemia was 11.9 after Hodgkin's disease, 3.7 after ovarian cancer and 2.5 after testicular cancer. Excess risks were also observed for cancers of the cervix and lung after Hodgkin's disease, for cancers of the breast, lung and rectum after ovarian cancer, and for contralateral testicular cancer. Confounding by social class or smoking does not explain these observations. The excess risks of leukaemia and of second cancer were higher in patients first diagnosed with Hodgkin's disease and ovarian cancer in the 1970s than for those first diagnosed in the 1960s. Increased use of multiple-agent chemotherapy regimes for these tumours in the 1970s may have contributed to these increases in excess risk.

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Cohort Study Analysis with a FORTRAN Computer Program

Cited by 241 publications

References 0 publications

Occupational Cancer in France: Epidemiology, Toxicology, Prevention, and Compensation

Occupational Cancer in France: Epidemiology, Toxicology, Prevention, and Compensation

Cancer morbidity in alcohol abusers

Second primary malignancy after Hodgkin's disease, ovarian cancer and cancer of the testis: A population-based cohort study

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