Cohort Profile Update: the Rotterdam Periconceptional Cohort and embryonic and fetal measurements using 3D ultrasound and virtual reality techniques

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

“…With this approach, we were able to keep track of offspring development throughout pregnancy, knowing that growth patterns are GA-dependent. All included longitudinal measurements have previously shown to have excellent inter- and intra-observer reproducibility [ 17 ]. The same fetal measurements at late gestation were analyzed both at single and multiple time points, using different measurement approaches, which reinforced the reliability of the results.…”

“…This study is embedded in the Rotterdam Periconception Cohort (Predict Study), a prospective tertiary hospital-based birth cohort study at the Department of Obstetrics and Gynecology of the Erasmus MC, University Medical Center, Rotterdam, The Netherlands. This is an ongoing study initiated in 2009, with the aim of investigating the association between parental periconception health and its impact on reproduction, pregnancy, and neonatal outcomes [ 17 ]. The study was approved by the Central Committee on Research in The Hague and the local Medical Ethics Committee of the Erasmus MC (MEC-2004-227).…”

“…Measurements of body size (CRL and EV) were performed from 6 + 0 to 13 + 6 weeks of gestation and measured with VR. In a subpopulation of the Predict Study (included population n = 118), measurements of head size (head volume (HV), biparietal diameter (BPD), occipitofrontal diameter (OFD), head circumference (HC), and cerebellar size (transcerebellar diameter (TCD)) were performed using an offline 3D software (4D view, GE Medical Systems) [ 17 , 24 ]. Such head and cerebellar measurements were performed at 9 and 11 weeks of gestation because the required reference points to perform such measurements were not visible earlier or only visible in a small proportion of the included population.…”

A high periconceptional maternal ultra-processed food consumption impairs embryonic growth: The Rotterdam periconceptional cohort

“…The virtual reality applications allow real depth perception; and semi-automated analyses of volumetric measures like the EV. Interobserver and intraobserver agreement have been reported as excellent, with an inter-and intraclass correlation coefficient of 0.99 [21,24]. Detailed information about the 3D-US scans can be found in "Cohort profile: The Rotterdam Periconceptional Cohort (Predict Study)" [20,21].…”

“…All participants provided written informed consent. The rationale and design of the Predict study were previously published [20,21]. A total of 2693 pregnancies from women of at least 18 years of age were recruited in the outpatient clinic before 13 þ0 weeks of gestation between November 2010 and December 2019.…”