Cohort Profile Update: the Rotterdam Periconceptional Cohort and embryonic and fetal measurements using 3D ultrasound and virtual reality techniques

Rousian, Melek; Schoenmakers, Sam; Eggink, Alex J.; Gootjes, Dionne V.; Koning, Anton H. J.; Köster, Maria; Mulders, A.; Baart, Esther B.; Laven, Joop S.E.; Steegers, Eric A.P.; Steegers‐Theunissen, Régine P.M.

doi:10.1093/ije/dyab030

Cited by 24 publications

(23 citation statements)

References 64 publications

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“…With this approach, we were able to keep track of offspring development throughout pregnancy, knowing that growth patterns are GA-dependent. All included longitudinal measurements have previously shown to have excellent inter- and intra-observer reproducibility [ 17 ]. The same fetal measurements at late gestation were analyzed both at single and multiple time points, using different measurement approaches, which reinforced the reliability of the results.…”

Section: Discussionmentioning

confidence: 99%

“…This study is embedded in the Rotterdam Periconception Cohort (Predict Study), a prospective tertiary hospital-based birth cohort study at the Department of Obstetrics and Gynecology of the Erasmus MC, University Medical Center, Rotterdam, The Netherlands. This is an ongoing study initiated in 2009, with the aim of investigating the association between parental periconception health and its impact on reproduction, pregnancy, and neonatal outcomes [ 17 ]. The study was approved by the Central Committee on Research in The Hague and the local Medical Ethics Committee of the Erasmus MC (MEC-2004-227).…”

Section: Methodsmentioning

confidence: 99%

“…Measurements of body size (CRL and EV) were performed from 6 + 0 to 13 + 6 weeks of gestation and measured with VR. In a subpopulation of the Predict Study (included population n = 118), measurements of head size (head volume (HV), biparietal diameter (BPD), occipitofrontal diameter (OFD), head circumference (HC), and cerebellar size (transcerebellar diameter (TCD)) were performed using an offline 3D software (4D view, GE Medical Systems) [ 17 , 24 ]. Such head and cerebellar measurements were performed at 9 and 11 weeks of gestation because the required reference points to perform such measurements were not visible earlier or only visible in a small proportion of the included population.…”

Section: Methodsmentioning

confidence: 99%

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First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

et al. 2022

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Homocysteine is a marker for derangements in one-carbon metabolism. Elevated homocysteine may represent a causal link between poor maternal nutrition and impaired embryonic and fetal development. We sought to investigate associations between reference range maternal homocysteine and embryonic and fetal growth. We enrolled 1060 singleton pregnancies (555 natural and 505 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancies) from November 2010 to December 2020. Embryonic and fetal body and head growth was assessed throughout pregnancy using three-dimensional ultrasound scans and virtual reality techniques. Homocysteine was negatively associated with first trimester embryonic growth in the included population (crown-rump length B −0.023 mm, 95% CI −0.038,−0.007, p = 0.004, embryonic volume B −0.011 cm3, 95% CI −0.018,−0.004, p = 0.003). After stratification for conception mode, this association remained in IVF/ICSI pregnancies with frozen embryo transfer (crown-rump length B −0.051 mm, 95% CI −0.081,−0.023, p < 0.001, embryonic volume B −0.024 cm3, 95% CI −0.039,−0.009, p = 0.001), but not in IVF/ICSI pregnancies with fresh embryo transfer and natural pregnancies. Homocysteine was not associated with longitudinal measurements of head growth in first trimester, nor with second and third trimester fetal growth. Homocysteine in the highest quartile (7.3–14.9 µmol/L) as opposed to the lowest (2.5–5.2 µmol/L) was associated with reduced birth weight in natural pregnancies only (B −51.98 g, 95% CI −88.13,−15.84, p = 0.005). In conclusion, high maternal homocysteine within the reference range is negatively associated with first trimester embryonic growth and birth weight, and the effects of homocysteine are dependent on conception mode.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

et al. 2022

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“…All participants provided written informed consent. The rationale and design of the Predict study were previously published [20,21]. A total of 2693 pregnancies from women of at least 18 years of age were recruited in the outpatient clinic before 13 þ0 weeks of gestation between November 2010 and December 2019.…”

Section: Study Populationmentioning

confidence: 99%

A high periconceptional maternal ultra-processed food consumption impairs embryonic growth: The Rotterdam periconceptional cohort

et al. 2022

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“…The Rotterdam Periconceptional Cohort (Predict study) is a large hospital-based cohort study conducted at the Erasmus MC, University Medical Center Rotterdam, the Netherlands. This prospective cohort focuses on the relationships between periconceptional maternal and paternal health and embryonic and fetal growth and development (Rousian et al, 2021;Steegers-Theunissen et al, 2016). 3D ultrasound scans are acquired at multiple points in time during the first trimester.…”

Section: The Rotterdam Periconceptial Cohortmentioning

confidence: 99%

Multi-Atlas Segmentation and Spatial Alignment of the Human Embryo in First Trimester 3D Ultrasound

Bastiaansen¹,

M.²,

Steegers‐Theunissen³

et al. 2022

Preprint

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Segmentation and spatial alignment of ultrasound imaging data acquired in the in first trimester are crucial for monitoring early human embryonic growth and development throughout this crucial period of life. Current approaches are either manual or semi-automatic and are therefore very time-consuming and prone to errors. To automate these tasks, we propose a multi-atlas framework for automatic segmentation and spatial alignment of the embryo using deep learning with minimal supervision. Our framework learns to register the embryo to an atlas, which consists of the ultrasound images acquired at a range of gestational ages, segmented and spatially aligned to a predefined standard orientation. From this, we can derive the segmentation of the embryo and put the embryo in standard orientation. Ultrasound images acquired at 8+0 till 12+6 weeks gestational age were used and eight pregnancies were selected as atlas images. We evaluated different fusion strategies to incorporate multiple atlases: 1) training the framework using atlas images from a single pregnancy, 2) training the framework with data of all available atlases and 3) ensembling of the frameworks trained per pregnancy. To evaluate the performance, we calculated the Dice score over the test set. We found that training the framework using all available atlases outperformed ensembling and gave similar results compared to the best of all frameworks trained on a single subject. Furthermore, we found that selecting images from the four atlases closest in gestational age out of all available atlases, regardless of the individual quality, gave the best results with a median Dice score of 0.72. We conclude that our framework can accurately segment and spatially align the embryo in first trimester 3D ultrasound images and is robust for the variation in quality that existed in the available atlases. Our code is publicly available at: https://github.com/wapbastiaansen/multi-atlas-seg-reg.

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Cohort Profile Update: the Rotterdam Periconceptional Cohort and embryonic and fetal measurements using 3D ultrasound and virtual reality techniques

Cited by 24 publications

References 64 publications

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort

A high periconceptional maternal ultra-processed food consumption impairs embryonic growth: The Rotterdam periconceptional cohort

Multi-Atlas Segmentation and Spatial Alignment of the Human Embryo in First Trimester 3D Ultrasound

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