Cohort Profile: The VicGeneration (VicGen) study: An Australian oral health birth cohort

Johnson, Stewart P.; Carpenter, Lauren; Amezdroz, Emily; Dashper, Stuart G.; Gussy, Mark; Calache, Hanny; Silva, Andrea M de; Waters, Elizabeth

doi:10.1093/ije/dyw024

Cited by 11 publications

(19 citation statements)

References 13 publications

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“…Table shows the characteristics of those children included in the analysis. Reasons for non‐participation across time‐points included participants moving from the area, loss to follow‐up, electing to miss a time‐point, and withdrawal due to time constraints …”

Section: Resultsmentioning

confidence: 99%

“…The LGA's were purposely selected to provide a higher level of disadvantage and cultural diversity and were in a mix of metropolitan, regional, and rural areas. This study was approved by the University of Melbourne Human Research Ethics Committee (HREC 0722543), and its protocol and cohort profile have been published …”

Section: Methodsmentioning

confidence: 99%

“…Clinical oral examinations of children in the VicGen cohort were completed at 18 months and 3, 4, and 5 years of age . Modified International Caries Detection and Assessment System criteria (ICDAS II) were used for caries assessment.…”

Section: Methodsmentioning

confidence: 99%

“…ICDAS II is validated for use with children and has been shown to be of acceptable validity and reproducibility for epidemiological and cohort studies . In total, 259 children completed the final visit at 5 years of age . For the current study, a series of inclusion criteria were applied to those 259 children, including non‐contradictory clinical data collection over all four visits and no missed data collection visits.…”

Section: Methodsmentioning

confidence: 99%

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Feasibility and development of a cariogenic diet scale for epidemiological research

Amezdroz

Carpenter

Johnson

et al. 2019

Int J Paed Dentistry

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Background Diet cariogenicity plays a major role as both a protective and risk factor in the development of early childhood caries (ECC). Aim Develop a scale measuring the cariogenicity of foods and beverages and employ it to describe the cariogenicity of young children's diets and predict dental caries outcomes. Design Scores of cariogenicity and consumption frequency were applied to food frequency questionnaire (FFQ) collected from an Australian children's cohort study with three time‐points of data. One‐way ANOVA, with post hoc Tukey test compared mean cariogenic scale measured at 18 months between the subsample of children with caries classification at age 5 years. Results At 6 months, children's mean cariogenic score was 10.05, increasing to 34.18 at 12 and 50.00 at 18 months. Mean cariogenic scale score at 18 months was significantly higher in children with advanced disease at 5 years (mean scale score: 59.0 ± 15.9) compared to those that were healthy (mean score 47.7 ± 17.5, P = 0.007) or had mild‐moderate disease (mean score 48.2 ± 17.3, P = 0.008). Conclusions The cariogenic diet scale provides a useful indication of the increasing cariogenicity of children's diets with age and highlights the incorporation of discretionary choice foods and beverages into the diets of young children much earlier than nutritionally recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Feasibility and development of a cariogenic diet scale for epidemiological research

Amezdroz

Carpenter

Johnson

et al. 2019

Int J Paed Dentistry

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“…A PubMed search using the terms “cohort profile” and “children” identified 116 publications that contained this type of information. Table 2 provides a summary of the six cohort profiles published in 2016 [37–42]. While inclusion in such a repository would require further investigation of many of the issues discussed above, including data-sharing permissions and investigator interest, we encourage pediatric societies and individual researchers to begin to think about how shared resources can be created to serve the larger pediatric research community.…”

Section: Discussionmentioning

confidence: 99%

Big and disparate data: considerations for pediatric consortia

Stingone

Mervish

Kovatch

et al. 2017

Current Opinion in Pediatrics

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Purpose of the review Increasingly, there is a need for examining exposure disease associations in large, diverse datasets to understand the complex determinants of pediatric disease and disability. Recognizing that children’s health research consortia will be important sources of big data, it is crucial for the pediatric research community to be knowledgeable about the challenges and opportunities that they will face. This review will provide examples of existing children’s health consortia; highlight recent pooled analyses conducted by children’s health research consortia; address common challenges of pooled analyses and provide recommendations to advance collective research efforts in pediatric research. Recent findings Formal consortia and other collective-science initiatives are increasingly being created to share individual data from a set of relevant epidemiological studies to address a common research topic. There are practical challenges to the participation of investigators within consortia that need to be addressed, including providing centralized data management, addressing barriers to data sharing and harmonization of data across studies and respecting the data ownership of original investigators. Summary Researchers who access consortia with data centers will be able to go far beyond their initial hypotheses and potentially accomplish research that was previously thought infeasible or too costly.

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Oral and craniofacial research in the Generation R study: an executive summary

van Meijeren-van Lunteren,

Liu,

Veenman

et al. 2023

Clin Oral Invest

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Objectives Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve (equal access to) oral health care systems, and to develop effective oral health promotion programs. Longitudinal population-based (birth-)cohort studies are very suitable to study risk factors on common oral diseases and have the potential to emphasize the importance of a healthy start for oral health. In this paper, we provide an overview of the comprehensive oral and craniofacial dataset that has been collected in the Generation R study: a population-based prospective birth cohort in the Netherlands that was designed to identify causes of health from fetal life until adulthood. Methods Within the multidisciplinary context of the Generation R study, oral and craniofacial data has been collected from the age of 3 years onwards, and continued at the age of six, nine, and thirteen. Data collection is continuing in 17-year-old participants. Research outcomes In total, the cohort population comprised 9749 children at birth, and 7405 eligible participants at the age of seventeen. Based on questionnaires, the dataset contains information on oral hygiene, dental visits, oral habits, oral health–related quality of life, orthodontic treatment, and obstructive sleep apnea. Based on direct measurements, the dataset contains information on dental caries, developmental defects of enamel, objective orthodontic treatment need, dental development, craniofacial characteristics, mandibular cortical thickness, and 3D facial measurements. Conclusions Several research lines have been set up using the oral and craniofacial data linked with the extensive data collection that exists within the Generation R study. Clinical relevance Being embedded in a multidisciplinary and longitudinal birth cohort study allows researchers to study several determinants of oral and craniofacial health, and to provide answers and insight into unknown etiologies and oral health problems in the general population.

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Cohort Profile: The VicGeneration (VicGen) study: An Australian oral health birth cohort

Cited by 11 publications

References 13 publications

Feasibility and development of a cariogenic diet scale for epidemiological research

Feasibility and development of a cariogenic diet scale for epidemiological research

Big and disparate data: considerations for pediatric consortia

Oral and craniofacial research in the Generation R study: an executive summary

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