Cohort Profile: The transition from childhood to adolescence in European children–how I.Family extends the IDEFICS cohort

Ahrens, Wolfgang; Siani, Alfonso; Adan, Roger A.H.; Henauw, Stefaan De; Eiben, Gabriele; Gwozdz, Wencke; Hebestreit, Antje; Hunsberger, Monica; Kaprio, Jaakko; Krogh, Vittorio; Lissner, Lauren; Molnár, Denés; Moreno, Luís A.; Page, Angie S; Picó, Catalina; Reisch, Lucia A.; Smith, Robert; Tornaritis, Michael; Veidebaum, Toomas; Williams, Garrath; Pohlabeln, Hermann; Pigeot, Iris

doi:10.1093/ije/dyw317

Cited by 102 publications

(138 citation statements)

References 53 publications

(46 reference statements)

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“…For the IDEFICS study, 2–9‐year‐old children from Belgium, Cyprus, Estonia, Germany, Hungary, Italy, Spain and Sweden were first examined in 2007/08 ( N = 16,228) and again in 2009/10 after an intervention aiming to prevent childhood overweight ( N = 11,041 plus 2,555 newcomers; Ahrens et al., ). In 2013/14, children participating in IDEFICS ( N = 7,105) and some newly recruited siblings ( N = 2,512) were (re‐)examined in the framework of the I.Family study (Ahrens et al., ).…”

Section: Methodsmentioning

confidence: 99%

Cross‐sectional and longitudinal associations between psychosocial well‐being and sleep in European children and adolescents

Thumann

Börnhorst

Michels

et al. 2019

Journal of Sleep Research

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Research on associations of positive mental health, in contrast to mental ill‐health, with sleep duration and sleep disturbances in young populations is scarce. In particular, longitudinal studies focussing on the influence of positive mental health on sleep characteristics are lacking. Therefore, we investigated cross‐sectional and longitudinal associations of psychosocial well‐being with sleep duration and sleep disturbances. For the cross‐sectional analysis, we used data of 3‐15‐year‐old children and adolescents participating in the 2013/14 examination of the European IDEFICS/I.Family cohort study (N = 6,336). The longitudinal analysis was restricted to children who also participated in the 2009/10 examination (N = 3,379). Associations between a psychosocial well‐being score created from 16 items of the KINDLR Health‐Related Quality of Life Questionnaire covering emotional well‐being, self‐esteem and social relationships, an age‐standardized nocturnal sleep duration z‐score and two sleep disturbance indicators (“trouble getting up in the morning”, “difficulties falling asleep”) were estimated using linear and logistic mixed‐effects models. Cross‐sectionally, a higher well‐being score was associated with longer sleep duration and lower odds of sleep disturbances. A positive change in the well‐being score over the 4‐year period was associated with longer sleep duration and lower odds of sleep disturbances at follow‐up. However, there was only weak evidence that higher psychosocial well‐being at baseline was associated with better sleep 4 years later. Thus, our results suggest that increases in well‐being are associated with improvements in both sleep duration and sleep disturbances, but that well‐being measured at one point in time does not predict sleep characteristics several years later.

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Section: Methodsmentioning

confidence: 99%

Cross‐sectional and longitudinal associations between psychosocial well‐being and sleep in European children and adolescents

Thumann

Börnhorst

Michels

et al. 2019

Journal of Sleep Research

View full text Add to dashboard Cite

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“…Follow-up examinations were conducted after two (T1) and six (T3, I.Family study) years; the design of this cohort study has been described in detail elsewhere [29, 30]. However, in this study, only cross-sectional data from the IDEFICS baseline survey were included as only at T0 a large number of children with FA data was available.…”

Section: Methodsmentioning

confidence: 99%

The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children—Analyses based on path models

et al. 2017

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BackgroundThe recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.MethodsA subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (T

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“…Follow-up examinations were conducted two (T1) and six (T3, I.Family study) years later; the study design has been described in detail elsewhere [27, 28]. In brief, the IDEFICS/I.Family study comprises one of the largest prospective European child cohorts.…”

Section: Methodsmentioning

confidence: 99%

Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents – Results from the IDEFICS/I.Family Cohort

et al. 2016

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BackgroundPolyunsaturated n-3 and n-6 polyunsaturated fatty acids (PUFA) are precursors of biologically active metabolites that affect blood pressure (BP) regulation. This study investigated the association of n-3 and n-6 PUFA and BP in children and adolescents.MethodsIn a subsample of 1267 children aged 2–9 years at baseline of the European IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort whole blood fatty acids were measured by a validated gas chromatographic method. Systolic and diastolic BP was measured at baseline and after two and six years. Mixed-effects models were used to assess the associations between fatty acids at baseline and BP z-scores over time adjusting for relevant covariables. Models were further estimated stratified by sex and weight status.ResultsThe baseline level of arachidonic acid was positively associated with subsequent systolic BP (β = 0.08, P = 0.002) and diastolic BP (β = 0.07, P<0.001). In thin/normal weight children, baseline alpha-linolenic (β = -1.13, P = 0.003) and eicosapentaenoic acid (β = -0.85, P = 0.003) levels were inversely related to baseline and also to subsequent systolic BP and alpha-linolenic acid to subsequent diastolic BP. In overweight/obese children, baseline eicosapentaenoic acid level was positively associated with baseline diastolic BP (β = 0.54, P = 0.005).ConclusionsLow blood arachidonic acid levels in the whole sample and high n-3 PUFA levels in thin/normal weight children are associated with lower and therefore healthier BP. The beneficial effects of high n-3 PUFA on BP were not observed in overweight/obese children, suggesting that they may have been overlaid by the unfavorable effects of excess weight.

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Cohort Profile: The transition from childhood to adolescence in European children–how I.Family extends the IDEFICS cohort

Cited by 102 publications

References 53 publications

Cross‐sectional and longitudinal associations between psychosocial well‐being and sleep in European children and adolescents

Cross‐sectional and longitudinal associations between psychosocial well‐being and sleep in European children and adolescents

The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children—Analyses based on path models

Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents – Results from the IDEFICS/I.Family Cohort

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