Cohort Profile: The Tongji Maternal and Child Health Cohort (TMCHC)

Zhong, Chunrong; Chen, Renjuan; Zhou, Xian; Liu, Chaoqun; Huang, Li; Li, Qian; Xu, Shangzhi; Chen, Xi; Xiong, Ting; Wang, Weiye; Gao, Qin; Zhang, Hongmin; Wu, Yuanjue; Miao, Hong; Wu, Jiangyue; Cui, Weigang; Li, Xiating; Wang, Weiming; Lin, Lixia; Wang, Huanzhuo; Gao, Duan; Li, Nan; Li, De; Zhang, Guofu; Wang, Xiaoyi; Zhang, Xu; Wu, Meng; Yang, Sen; Cao, Xiyu; Tan, Tianqi; Tu, Menghan; Guo, Jingrong; Hu, Wenqi; Zhu, Wenwen; Xiao, Daxiang; Gong, Lin; Zhang, Huaqi; Jin, Liu; Yang, Siyu; Wei, Sheng; Xiao, Mei; Sun, Guoqiang; Xiong, Guoping; Ni, Zemin; Wang, Jing; Zhang, Jin; Yang, Xuefeng; Hao, Liping; Yang, Huixia; Yang, Nianhong

doi:10.1093/ije/dyac209

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…All subjects were drawn from the TMCHC, a population-based prospective cohort study primarily designed to explore maternal nutrition, lifestyle, and environmental effects on the health and disease of mother-infant pairs in Wuhan, Hubei Province, central China [ 19 ]. In TMCHC, pregnant women were enrolled prior to 16 weeks of gestation and followed up across prenatal periods.…”

Section: Methodsmentioning

confidence: 99%

Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

Tan,

Chen,

Zhu

et al. 2023

BMC Med

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Background Deoxynivalenol (DON), one of the most prevalent mycotoxins, has been found to cause fetal growth retardation in animals. However, limited evidence exists regarding its effects on pregnant women. Methods Maternal urinary concentration of total DON (tDON) and free DON (fDON) in the second trimester was measured using liquid chromatography with tandem mass spectrometry. Provisional daily intake (PDI) of DON was calculated based on tDON concentration. Linear and logistic regression models were used to evaluate the association between DON exposure levels and birth weight, birth length, and the risk of small for gestational age (SGA). Results Among 1538 subjects, the median concentrations of tDON and fDON were 12.1 ng/mL and 5.1 ng/mL, respectively. The PDI values revealed that the median DON intake was 0.7 µg/kg bw, and 35.9% of the total population exceeded the provisional maximum tolerable daily intake (PMTDI) of 1 µg/kg bw. Compared with the lowest tertile, birth weight decreased by 81.11 g (95% CI: -127.00, -35.23) for tDON (P-trend < 0.001) and 63.02 g (95% CI: -108.72, -17.32) for fDON (P-trend = 0.004) in the highest tertile. Each unit increase in Ln-tDON and Ln-fDON was also inversely associated with birth weight. Furthermore, compared to those who did not exceed PMTDI, pregnant women whose PDI exceeded PMTDI had lower birth weight (β = -79.79 g; 95% CI: -119.09, -40.49) and birth length (β = -0.21 cm; 95% CI: -0.34, -0.07), and a higher risk of SGA (OR = 1.48; 95% CI: 1.02, 2.15) in their offspring. Similar associations with birth weight, birth length, and SGA were found when comparing the highest tertile of PDI to the lowest tertile (all P-trend < 0.05). Conclusions Maternal DON exposure is related to decreased birth weight. Our findings implicate that DON exposure during pregnancy may cause fetal growth faltering, and measures should be taken to reduce DON exposure in pregnant women.

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Section: Methodsmentioning

confidence: 99%

Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

Tan,

Chen,

Zhu

et al. 2023

BMC Med

Self Cite

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Longitudinal plasma magnesium status during pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

Cao

Zhang

et al. 2023

Environ Sci Pollut Res

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Remnant Cholesterol Is Associated With Gestational Diabetes Mellitus: A Cohort Study

Wang

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context The association between remnant cholesterol (RC) and gestational diabetes mellitus (GDM) risk is unclear. Objective This study investigated the association between RC and GDM. Methods We used data from the Tongji Maternal and Child Health Cohort, a prospective cohort study in China. Fasting lipid concentrations were measured around 16 weeks’ gestation. RC was calculated as total cholesterol minus low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. GDM was diagnosed by a 75-g oral-glucose-tolerance test (OGTT) at 24–28 weeks’ gestation. Log-Poisson regression models were performed to estimate RRs of GDM across quartiles of RC levels and triglyceride (TG) levels after adjustment for potential confounds. TG and RC were mutually adjusted. Results Among 2528 women, 256 (10.1%) of them developed GDM. The adjusted RRs (95% CIs) for GDM across increasing quartiles of RC were 1.00 (reference), 1.35 (0.91, 1.99), 1.68 (1.16, 2.45), and 1.73 (1.19, 2.50), respectively. Compared to pregnant women without three risk indicators (TG <2.08 mmol/L, RC <0.40 mmol/L, and pre-BMI <24.0kg/m2), the risk of GDM elevated in those with normal pre-BMI but high RC (aRR:1.54; 95%CI: 1.08, 2.19) or high TG (aRR:2.15; 95%CI: 1.33, 3.49). For those with all three risk indicators, the risk of GDM was the highest (aRR:4.80; 95%CI: 3.20, 7.18). Conclusion Elevated RC levels were associated with the increased risk of GDM and independent of traditional risk factors. Pregnant women with high pre-BMI, high TG, and high RC were greatly increased the risk of GDM.

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Cohort Profile: The Tongji Maternal and Child Health Cohort (TMCHC)

Cited by 4 publications

References 38 publications

Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

Longitudinal plasma magnesium status during pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

Remnant Cholesterol Is Associated With Gestational Diabetes Mellitus: A Cohort Study

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