Cohort Profile: The Taiwan Maternal and Infant Cohort Study (TMICS) of phthalate exposure and health risk assessment

Wu, Chia Fang; Chen, Hui Ming; Sun, Chien Wen; Chen, Mei Lien; Hsieh, Chia‐Jung; Wang, Shu Li; Wu, Ming Tsang

doi:10.1093/ije/dyy067

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…Major risk contributors among the plasticizers in our study were DEHP, DiBP and DnBP, which is comparable to the studies of Saudi, Thai, Indonesian, Chinese and Brazilian children [ 13 , 26 , 27 ]. DEHP has frequently been identified as a major risk-driving phthalate in general populations [ 28 ] and pregnant women [ 29 ]. Therefore, identification of exposure sources of DEHP among children is the most critical factor in risk management for phthalate exposure.…”

Section: Discussionmentioning

confidence: 99%

Exposure Characteristics and Cumulative Risk Assessment for Phthalates in Children Living near a Petrochemical Complex

Wang

Cheng

Ponnusamy

et al. 2023

Toxics

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Background: School-aged children living near plastics–producing factories may have higher risk of exposure to phthalates released during the manufacturing processes. Objectives: We aimed to investigate the urinary concentrations of phthalate metabolites in school-aged children living near a petrochemical complex and estimate the cumulative risk of phthalate exposure. Methods: We used a well-established cohort (Taiwan Petrochemical Complex Cohort for Children, TPE3C) of school-aged children (6–13 years old) living near polyvinyl chloride (PVC) and vinyl chloride monomer (VCM) factories in central Taiwan from October 2013 to September 2014. A total of 257 children were included from five elementary schools: Syu-Cuo Branch (n = 58, school A, ~0.9 km), Feng-An (n = 40, school B, ~2.7 km), Ciao-Tou (n = 58, school C, ~5.5 km), Mai-Liao (n = 37, school D, ~6.9 km), and Lung-Feng (n = 57, school E, ~8.6 km). We analyzed 11 metabolites of seven phthalates (including di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DnBP)) in urine. Daily intakes (DIs) were compared with acceptable intake levels to calculate the hazard quotient (HQ) for individual phthalates, and the cumulative risk for each child was assessed using a hazard index (HI), which was the sum of the the individual HQs. Results: The geometric mean and proportion of participants with HIs exceeding one for hepatic (HIhep) and reproductive (HIrep) effects were 0.33 (13.2%) and 0.24 (7.8%), respectively. The major contributors to phthalate exposure risk were DEHP, di-iso-butyl phthalate (DiBP) and DnBP in all children. Moreover, we observed a U shaped distribution of DEHP exposure by school distance from the PVC and VCM factories (school A: 7.48 μg/kg/day and school E: 80.44 μg/kg/day). This may be due to emissions (closest) and and being located downwind of PVC scrap incineration (farthest). Conclusions: Our findings suggest that children living near a petrochemical complex were at a greater risk of phthalate exposure than normal school-aged children and that phthalate exposure was mainly attributed to DEHP, DiBP and DnBP. In addition, inhalation may have been a risk factor for people living near to PVC and VCM factories.

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Section: Discussionmentioning

confidence: 99%

Exposure Characteristics and Cumulative Risk Assessment for Phthalates in Children Living near a Petrochemical Complex

Wang

Cheng

Ponnusamy

et al. 2023

Toxics

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“…Each of those existing cohorts focused on different exposures or outcomes, starting their recruitment at different childhood periods and following up their participants in different time frames. For example, some child cohorts have examined the impacts of environmental factors [e.g., lead exposure and micronutrient deficiency (41,42), phthalate exposure (43), early life feeding practice (44), and eating behaviors (45)] on children's cognitive and behavior outcomes [e.g., China Jintan Child Cohort Study (41,42), Taiwan Maternal and Infant Cohort Study (43)], adiposity [e.g., Jiaxing Birth Cohort (44), Studying Impact of Nutrition on Growth (13), Childhood Obesity Study in China Mega-cities (45)], and physical, psychological, behavioral and sexual development [e.g., China-Anhui Birth Cohort study (17)]. Among them, only the China-Anhui Birth Cohort study has considered puberty timing as one of their outcomes.…”

Section: Discussionmentioning

confidence: 99%

The Chinese Adolescent Cohort Study: Design, Implementation, and Major Findings

et al. 2021

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The importance of diet quality on children's growth is being increasingly recognized. The Chinese Adolescent Cohort (CAC) is a longitudinal cohort study to comprehensively investigate the health impacts of nutritional factors on child growth. From 2013 to 2018, 6,967 children aged 6–8 years have been recruited from 23 primary schools in Sichuan, Guizhou, and Chongqing, which have been planned to be followed up annually until their age of 15 years. Regular assessments included the measurement of height, weight, waist circumference, and skinfold thicknesses; pubertal development was examined by trained investigators according to Tanner stages; dietary intake was obtained by three 24-h recalls and food frequency questionnaire; validated questionnaires were used to estimate socio-demographic characteristics, physical activity, and sedentary behaviors. Findings from the CAC baseline and the first follow-up data suggested that higher protein intake among girls and unhealthy eating habits among children might increase the risk for childhood obesity. Also, higher intakes of grain and meat and lower overall diet quality and intakes of dietary fiber and tuber might be associated with advanced pubertal development. Those results indicated that the CAC study could contribute to the development of strategies for optimizing Chinese children's health.

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“…Following the birth of the babies, samples of cord blood and placental tissue were aliquoted and stored at − 70 °C for future research. Details pertaining to the study design can be found in previous articles 33 , 34 .…”

Section: Methodsmentioning

confidence: 99%

Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics

Tran

Kuo

Low

et al. 2023

Sci Rep

Self Cite

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Recent experimental and observational research has suggested that childhood allergic asthma and other conditions may be the result of prenatal exposure to environmental contaminants, such as di-(2-ethylhexyl) phthalate (DEHP). In a previous epidemiological study, we found that ancestral exposure (F0 generation) to endocrine disruptors or the common plasticizer DEHP promoted allergic airway inflammation via transgenerational transmission in mice from generation F1 to F4. In the current study, we employed a MethylationEPIC Beadchip microarray to examine global DNA methylation in the human placenta as a function of maternal exposure to DEHP during pregnancy. Interestingly, global DNA hypomethylation was observed in placental DNA following exposure to DEHP at high concentrations. Bioinformatic analysis confirmed that DNA methylation affected genes related to neurological disorders, such as autism and dementia. These results suggest that maternal exposure to DEHP may predispose offspring to neurological diseases. Given the small sample size in this study, the potential role of DNA methylation as a biomarker to assess the risk of these diseases deserves further investigation.

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Cohort Profile: The Taiwan Maternal and Infant Cohort Study (TMICS) of phthalate exposure and health risk assessment

Cited by 23 publications

References 23 publications

Exposure Characteristics and Cumulative Risk Assessment for Phthalates in Children Living near a Petrochemical Complex

Exposure Characteristics and Cumulative Risk Assessment for Phthalates in Children Living near a Petrochemical Complex

The Chinese Adolescent Cohort Study: Design, Implementation, and Major Findings

Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics

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