Cohort Profile: The Nordic Perinatal Bereavement Cohort

Li, Jiong; Vestergaard, Mogens; Obel, Carsten; Cnattingus, Sven; Gissler, Mika; Olsen, Jeppe

doi:10.1093/ije/dyq127

Cited by 42 publications

(58 citation statements)

References 33 publications

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“…27 This population-based cohort study 28 . These registers include data on practically all deliveries in Denmark and Sweden, respectively, and the information is collected from medical records in prenatal, delivery and neonatal care.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

“…30 Socio-demographic factors were obtained from the Danish Integrated Database for Longitudinal Labor Market Research (IDA), the Danish Civil Registry System, the Swedish Education Registry and the Swedish Registry of Population and Population Changes. 28 Outcome measurements Data on cancer were obtained from national cancer registries, and the registration and coding practices have been described elsewhere. 31 32 The main outcomes of interest were all incident cancers (ICD-7 codes 104-205, ICD-10 codes C00-97) diagnosed before 15 years of age and the most frequent childhood cancers for which uterine environment has been suggested to play a role: 3 4 6-9 leukaemias (ICD-7 code 204, ICD-10 codes C91-95), lymphomas (ICD-7 code 201-203, ICD-10 code C81-C85), brain and nervous system tumours (ICD-7 code 193, ICD-10 codes C70-C72, C47, C74.1), retinoblastoma (ICD-7 code 192 and PAD 436, ICD-10 code C69.2), Wilms' tumour (ICD-7 code 180 and PAD 886, ICD-10 code C64.9), hepatoblastoma (ICD-7 code 155, ICD-10 code C22), malignant bone tumours (ICD-7 code 196, ICD-10 codes C40-C41) and testicular cancer (ICD-7 code 178, ICD-10 code C62).…”

Section: Study Design and Study Populationmentioning

confidence: 99%

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The 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children

Cnattingus

Gissler

et al. 2012

BMJ Open

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ObjectiveThe aetiology of childhood cancer remains largely unknown but recent research indicates that uterine environment plays an important role. We aimed to examine the association between the Apgar score at 5 min after birth and the risk of childhood cancer.DesignNationwide population-based cohort study.SettingNationwide register data in Denmark and Sweden.Study populationAll live-born singletons born in Denmark from 1978 to 2006 (N=1 771 615) and in Sweden from 1973 to 2006 (N=3 319 573). Children were followed up from birth to 14 years of age.Main outcome measuresRates and HRs for all childhood cancers and for specific childhood cancers.ResultsA total of 8087 children received a cancer diagnosis (1.6 per 1000). Compared to children with a 5-min Apgar score of 9–10, children with a score of 0–5 had a 46% higher risk of cancer (adjusted HR 1.46, 95% CI 1.15 to 1.89). The potential effect of low Apgar score on overall cancer risk was mostly confined to children diagnosed before 6 months of age. Children with an Apgar score of 0–5 had higher risks for several specific childhood cancers including Wilms’ tumour (HR 4.33, 95% CI 2.42 to 7.73).ConclusionsA low 5 min Apgar score was associated with a higher risk of childhood cancers diagnosed shortly after birth. Our data suggest that environmental factors operating before or during delivery may play a role on the development of several specific childhood cancers.

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Section: Study Design and Study Populationmentioning

confidence: 99%

Section: Study Design and Study Populationmentioning

confidence: 99%

The 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children

Cnattingus

Gissler

et al. 2012

BMJ Open

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“…We established the nordic Perinatal Bereavement cohort (details have been previously published) 26 using prospectively collected data from national registers in Denmark. every person born in or immigrating to Denmark obtains a unique identification number by which the individual is registered throughout the Danish health care systems, covering information on birth, diseases, familiar constitution, education, and death.…”

Section: Methodsmentioning

confidence: 99%

Maternal Bereavement and Cryptorchidism in Offspring

Ingstrup¹,

Olsen²,

Wu³

et al. 2015

Epidemiology

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“…25 In brief, the unique civil personal registration number, which is assigned to all live-born children and new residents, was used to link children to their relatives and to information on birth, death, demographics, social data and various health outcomes from different national registers. Children of mothers with no personal registration number recorded were excluded as they could not be linked to their relatives (n=10 641; 0.17%).…”

Section: Materials and Methods Study Participants And Follow-upmentioning

confidence: 99%

Early life bereavement and childhood cancer: a nationwide follow-up study in two countries

et al. 2013

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ObjectiveChildhood cancer is a leading cause of child deaths in affluent countries, but little is known about its aetiology. Psychological stress has been suggested to be associated with cancer in adults; whether this is also seen in childhood cancer is largely unknown. We investigated the association between bereavement as an indicator of severe childhood stress exposure and childhood cancer, using data from Danish and Swedish national registers.DesignPopulation-based cohort study.SettingDenmark and Sweden.ParticipantsAll live-born children born in Denmark between 1968 and 2007 (n=2 729 308) and in Sweden between 1973 and 2006 (n=3 395 166) were included in this study. Exposure was bereavement by the death of a close relative before 15 years of age. Follow-up started from birth and ended at the first of the following: date of a cancer diagnosis, death, emigration, day before their 15th birthday or end of follow-up (2007 in Denmark, 2006 in Sweden).Outcome measuresRates and HRs for all childhood cancers and specific childhood cancers.ResultsA total of 1 505 938 (24.5%) children experienced bereavement at some point during their childhood and 9823 were diagnosed with cancer before the age of 15 years. The exposed children had a small (10%) increased risk of childhood cancer (HR 1.10; 95% CI 1.04 to 1.17). For specific cancers, a significant association was seen only for central nervous system tumours (HR 1.14; 95% CI 1.02 to 1.28).ConclusionsOur data suggest that psychological stress in early life is associated with a small increased risk of childhood cancer.

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Cohort Profile: The Nordic Perinatal Bereavement Cohort

Cited by 42 publications

References 33 publications

The 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children

The 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children

Maternal Bereavement and Cryptorchidism in Offspring

Early life bereavement and childhood cancer: a nationwide follow-up study in two countries

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