Cohort Profile: The Melbourne Collaborative Cohort Study (Health 2020)

Milne, Roger L.; Fletcher, Astrid; MacInnis, Robert J.; Hodge, Allison; Hopkins, Alex; Bassett, Julie K.; Bruinsma, Fiona; Lynch, Brigid M.; Dugué, Pierre Antoine; Jayasekara, Harindra; Brinkman, Maree; Popowski, L V; Baglietto, Laura; Severi, Gianluca; O’Dea, Kerin; Hopper, John L.; Southey, Melissa C.; English, Dallas R.; Giles, Graham G.

doi:10.1093/ije/dyx085

Cited by 132 publications

(161 citation statements)

References 77 publications

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“…We used data collected from participants in the MCCS, a prospective study of 41,513 healthy adult volunteers (24,469 women) aged between 27 and 76 years (99.3% aged 40–69) when recruited between 1990 and 1994 . DNA samples were collected from peripheral blood drawn at the time of recruitment (1990–1994) or at the wave 2 follow‐up visit (2003–2007).…”

Section: Methodsmentioning

confidence: 99%

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Dugué

Bassett

Joo

et al. 2017

Intl Journal of Cancer

170

166

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The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methylation and called them "age acceleration." We aimed to assess the associations of age acceleration with risk of and survival from seven common cancers. Seven case-control studies of DNA methylation and colorectal, gastric, kidney, lung, prostate and urothelial cancer and B-cell lymphoma nested in the Melbourne Collaborative Cohort Study were conducted. Cancer cases, vital status and cause of death were ascertained through linkage with cancer and death registries. Conditional logistic regression and Cox models were used to estimate odds ratios (OR) and hazard ratios (HR) and 95% confidence intervals (CI) for associations of five age acceleration measures derived from the Human Methylation 450 K Beadchip assay with cancer risk (N = 3,216 cases) and survival (N = 1,726 deaths), respectively. Epigenetic aging was associated with increased cancer risk, ranging from 4% to 9% per five-year age acceleration for the 5 measures considered. Heterogeneity by study was observed, with stronger associations for risk of kidney cancer and B-cell lymphoma. An associated increased risk of death following cancer diagnosis ranged from 2% to 6% per five-year age acceleration, with no evidence of heterogeneity by cancer site. Cancer risk and mortality were increased by 15-30% for the fourth versus first quartile of age acceleration. DNA methylation-based measures of biological aging are associated with increased cancer risk and shorter cancer survival, independently of major health risk factors.

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Section: Methodsmentioning

confidence: 99%

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Dugué

Bassett

Joo

et al. 2017

Intl Journal of Cancer

170

166

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“…Greek-born and Italian-born participants were oversampled to extend the range of dietary, lifestyle and genetic characteristics of the population. A follow-up survey conducted between 2003 and 2007 (wave 2) repeated most baseline measures 20. Written informed consent was provided by all participants.…”

Section: Methodsmentioning

confidence: 99%

Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality

Seviiri

Lynch

Hodge

et al. 2017

Heart

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“…20 Study participants were recruited from the metropolitan area of Melbourne in Victoria, Australia. 20 Study participants were recruited from the metropolitan area of Melbourne in Victoria, Australia.…”

Section: Study Samplementioning

confidence: 99%

Dietary intake of nutrients involved in one‐carbon metabolism and risk of urothelial cell carcinoma: A prospective cohort study

Dugué

Brinkman

Hodge

et al. 2018

Intl Journal of Cancer

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Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N = 41,513) for over 20 years and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221). Energy-adjusted dietary intakes of B vitamins (B1, B2, B3, B5, B6, B8, B9 and B12) and methionine were estimated from a 121-item food frequency questionnaire administered at baseline (1990-1994), using the residuals method. We used Cox regression models to compute hazard ratios (HRs) of UCC risk per standard deviation (SD) of log-transformed nutrient intakes and 95% confidence intervals, adjusted for potential confounders. We investigated associations by tumor subtype, and tested interactions with sex, country of birth, smoking and alcohol drinking. The risk of UCC appeared not to be associated with intake of B-group vitamins or methionine, and findings were consistent across tumor subtypes and across demographic and lifestyle characteristics of the participants. A potential interaction between vitamin B1 and alcohol drinking was observed (all participants: HR per 1 SD = 0.99 (0.91-1.09), never drinkers: HR = 0.81 (0.69-0.97), p-interaction = 0.02), which needs to be confirmed by other studies. Our findings do not indicate that dietary intake of nutrients involved in one-carbon metabolism are associated with UCC risk.

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Cohort Profile: The Melbourne Collaborative Cohort Study (Health 2020)

Cited by 132 publications

References 77 publications

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

Resting heart rate, temporal changes in resting heart rate, and overall and cause-specific mortality

Dietary intake of nutrients involved in one‐carbon metabolism and risk of urothelial cell carcinoma: A prospective cohort study

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