Cohort Profile: The Irish Longitudinal Study on Ageing

Kearney, Patricia M.; Cronin, Hilary; O’Regan, Claire; Kamiya, Yumiko; Savva, George M.; Whelan, Brendan J.; Kenny, RoseAnne

doi:10.1093/ije/dyr116

Cited by 321 publications

(288 citation statements)

References 2 publications

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“…A total of 8,175 participants aged 50 years and older were recruited to the TILDA study [14]. Of these 5,036 agreed to undergo an in--centre health assessment, 4,763 of whom had technically adequate data for HRV analysis (see Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A nationally representative sample was selected using the regularly updated RANSAM sampling technique [43]. Further detail of the study design is published elsewhere [14]. Data collected within TILDA are composed of three parts: (1) computer--assisted personal interviewing (CAPI), (2) self--completion questionnaire, and (3) a physical health assessment.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive function was assessed in the TILDA study using a battery of cognitive tests [14]. This included the Montreal cognitive assessment (MOCA) [21], which was administered during the health assessment and used in the present study.…”

Section: Cognitive Assessmentmentioning

confidence: 99%

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Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Frewen¹,

Finucane

Savva³

et al. 2013

Clin Auton Res

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ObjectiveTo examine the independent association between heart rate variability (HRV) and cognitive performance, in a nationally representative population study of older adults. MethodsCross--sectional analysis of wave 1 data from the Irish longitudinal study on ageing (TILDA) was performed. A subset of 4,763 participants who underwent ECG recording during resting and paced breathing periods were used for the analysis. HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment (MOCA) score. Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index, after adjustment for covariates. ResultsThe mean age was 61.7 ± 8.3 years and 2,618 (55 %) were female. Lower quintiles of SDNN (P = 0.01--paced), LF (P = 0.001--paced), and LF:HF ratio (P = 0.049--paced) were significantly associated with lower MOCA scores (during both recording periods), independent of confounders. Sub--domains of MOCA responsible for the relationship were predominantly memory recall and language. InterpretationReduced HRV is significantly associated with lower cognitive performance at a population level in people aged 50 and older. This further strengthens the relationship between autonomic dysfunction and cognitive disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Frewen¹,

Finucane

Savva³

et al. 2013

Clin Auton Res

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“…This study is based on the first wave of data collected from October 2009 to July 2011. Details of the study design and data collection are available elsewhere [19]. Briefly, the sampling frame is the Irish Geodirectory, a listing of all residential addresses in the Republic of Ireland.…”

Section: Methodsmentioning

confidence: 99%

Effects of fear of falling and activity restriction on normal and dual task walking in community dwelling older adults

Donoghue¹,

Cronin²,

Savva³

et al. 2013

Gait & Posture

113

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Fear of falling (FOF) is associated with poor physical and psychosocial health and can have debilitating consequences especially when it leads to activity restriction. This study examined whether normal and dual task gait disruptions were independently associated with FOF and activity restriction or if they were fully explained by impaired health status. Data was obtained from The Irish Longitudinal Study on Ageing (TILDA). Community dwelling adults =65 years, with a Mini-Mental State Examination score =18 and who completed a gait assessment (n=1307) were divided into three groups: no FOF, FOF but no activity restriction (FOF-NAR), FOF with activity restriction (FOF-AR). Physical, psychosocial and cognitive measures were obtained and gait characteristics were assessed using a GAITRite(®) mat during normal and dual task (cognitive) walking. After adjusting for sociodemographics, physical, mental and cognitive health, FOF was associated with reduced gait speed and stride length and increased double support phase and step width in normal and dual task conditions; these changes were most pronounced in those who restrict activities as a result of FOF. These gait changes may be associated with an increased fall risk, however some changes especially increased step width may also reflect positive, compensatory adaptations to FOF. The results also highlight the importance of treating underlying health impairments and preventing the transition from FOF to activity restriction

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“…The adjusted response rate to the study was 62% and response to the selfcompletion questionnaire was 84%. Full details of the study sample and response rates have been described elsewhere (Kearney et al, 2011). Study participants were interviewed in their own homes by trained professional social interviewers who collected information regarding health, social and economic domains using Computer Assisted Personal Interviewing (CAPI).…”

Section: Study Design and Samplementioning

confidence: 99%

Depression, anxiety and cardiovascular disease: Which symptoms are associated with increased risk in community dwelling older adults?

Gallagher

O’Regan

Cronin

et al. 2012

Journal of Affective Disorders

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a b s t r a c tBackground: Depression is a risk factor for Cardiovascular Disease (CVD). It has been reported that somatic symptoms of depression and not cognitive symptoms are associated with increased risk although findings have been inconsistent. Few studies have examined whether co-morbid anxiety confers additive risk. Methods: We conducted a cross sectional analysis of 7872 community dwelling adults aged 50 years and over from The Irish LongituDinal Study on Ageing (TILDA). Depressive and anxiety symptoms were assessed with Center for Epidemiologic Studies Depression (CES-D) scale and the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS-A), respectively. We conducted logistic regression analyses to determine the relationship between depression, anxiety, individual depressive symptoms and CVD. We further determined whether co-morbid anxiety was associated with increased risk. Results: Seven hundred and thirty eight (9.4%) study participants reported clinically significant depression. Depression was associated with 80% increased risk of CVD following adjustment for cardiovascular risk factors. Individual depressive symptoms most consistently associated with CVD included low mood, sadness, amotivation, fatigue, diminished appetite and concentration difficulties. Anxiety was associated with increased risk of CVD but did not confer additive risk in participants with depression. Limitations: Cross sectional design. Conclusion: Core symptoms of depression, which are both cognitive and somatic in nature, are associated with increased risk of CVD while co-morbid anxiety did not confer additive risk. It is important that clinicians give due regard both to both cognitive and somatic symptoms of depression when determining cardiovascular risk. Future longitudinal investigation should confirm these findings and explore potential pathological mechanisms.

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Cohort Profile: The Irish Longitudinal Study on Ageing

Cited by 321 publications

References 2 publications

Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Effects of fear of falling and activity restriction on normal and dual task walking in community dwelling older adults

Depression, anxiety and cardiovascular disease: Which symptoms are associated with increased risk in community dwelling older adults?

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