Cohort Profile: The Hunter Community Study

McEvoy, Mark; Smith, Wayne; DʼEste, Catherine; Duke, Janine M.; Peel, Roseanne; Schofield, Peter R.; Scott, Rodney J.; Byles, Julie; Henry, David; Ewald, Ben; Hancock, Stephen; Smith, Derek R.; Attia, John

doi:10.1093/ije/dyp343

Cited by 101 publications

(138 citation statements)

References 27 publications

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“…Stroke mechanism was investigated using clinically appropriate tests including transoesophageal echocardiography and carotid duplex. In some patients, stroke severity was assessed using the National Institutes of Health Stroke Scale and later divided into minor (0-4), moderate (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), moderate to severe (16)(17)(18)(19)(20), and severe (21-42) stroke as previously described. 9 Controls were obtained from the Hunter Community Study (HCS) that has previously been described in detail.…”

Section: Subjects For Aims 1 Andmentioning

confidence: 99%

“…9 Controls were obtained from the Hunter Community Study (HCS) that has previously been described in detail. 12 HCS recruited community-dwelling men and women aged 55 to 85 years from Newcastle, New South Wales, based on listings in the electoral roll between 2004 and 2007. Controls were selected randomly who had no history of any type of stroke.…”

Section: Subjects For Aims 1 Andmentioning

confidence: 99%

“…At the time of recruitment, subjects were interviewed by research staff using standardized questionnaires. 9,12 Prior history of ever smoking, hypertension, diabetes mellitus, myocardial infarction, and atrial fibrillation was noted.…”

Section: Subjects For Aims 1 Andmentioning

confidence: 99%

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Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

Golledge

Clancy

Maguire

et al. 2014

Stroke

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Background and Purpose— Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. Methods— Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. Results— Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26–9.53 compared with 17.36; interquartile range, 14.01–22.46 ng/mL; P <0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81–8.75 ng/mL for modified Rankin scale 3–6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75–9.92 ng/mL for modified Rankin scale 0–2; n=194), P =0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. Conclusions— Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.

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Section: Subjects For Aims 1 Andmentioning

confidence: 99%

Section: Subjects For Aims 1 Andmentioning

confidence: 99%

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Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

Golledge

Clancy

Maguire

et al. 2014

Stroke

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“…Control subjects were selected randomly from the same geographical population and were healthy community-dwelling volunteers drawn from the Hunter Community Study. 13 Cases and controls were predominantly of self-reported European descent.…”

Section: Australia: Vascular Ischemia Studymentioning

confidence: 99%

The Association of the 4q25 Susceptibility Variant for Atrial Fibrillation With Stroke Is Limited to Stroke of Cardioembolic Etiology

Lemmens

Buysschaert

Geelen

et al. 2010

Stroke

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Background and Purpose-Genome-wide association studies recently identified 2 variants on chromosome 4q25 as susceptibility factors for atrial fibrillation. Interestingly, these variants were subsequently also shown to be associated with stroke. However, it remains unclear whether 4q25 associates with all the stroke subtypes or with cardioembolic stroke in particular, which is often attributable to atrial fibrillation. Methods-We performed a large case-control association study in 4199 ischemic stroke patients, all subtyped according to Trial of Org 10172 in Acute Stroke Treatment criteria, and 3750 controls derived from 6 studies conducted in Australia, Austria, Belgium, Poland, Spain, and Sweden. Two variants on chromosome 4q25, rs1906591 and rs10033464, were genotyped. Results-Within cases, the A-allele of rs1906591 was associated with atrial fibrillation (odds ratio, 1.64 [95% CI, 1.43 to 1.90]; Pϭ9.2 ⅐ 10 Ϫ12 ), whereas rs10033464 was only marginally associated. There was an association between overall ischemic stroke and rs1906591 (odds ratio, 1.20 [95% CI, 1.09 to 1.32]; Pϭ1.2 ⅐ 10 Ϫ4 ). However, this was probably caused by the large effect of stroke of cardioembolic etiology because no relation was obtained in any other subgroup of stroke. The rs10033464 variant failed to show any relationship with ischemic stroke. Conclusions-We replicated the association of the rs1906591 variant on chromosome 4q25 with atrial fibrillation and ischemic stroke of cardioembolic etiology. The 4q25 locus failed to associate with noncardiac subtypes of ischemic stroke. (Stroke.

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“…Participants were drawn from the Hunter Community Study-a study of the health of older persons in the regional city of Newcastle, Australia (for details see McEvoy et al, 2010). Briefly, between December 2004 and December 2007, community-dwelling individuals aged 55-85 years from the Newcastle area were randomly selected, stratified by age, from the Australian electoral roll and invited to participate in the study.…”

Section: Participantsmentioning

confidence: 99%

The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations

et al. 2015

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This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospitalisations. Participants (55-85 years) completed baseline depression and physical assessment. Those without self-reported cardiovascular events were followed prospectively for hospital admissions for angina, myocardial infarction and cerebral infarction (median 937 days). Across 5140 person-years of risk (N = 1692), there were 47 incident cardiovascular hospitalisations (2.8 %). Controlling for age and gender, interleukin (IL)-6, C-reactive protein (CRP), body mass index (BMI) and waist-to-hip ratio were associated with future cardiovascular events. Mediation analysis showed that CRP accounted for 8.1 % and IL-6 10.9 % of the effect of depression on cardiovascular events, and including the indirect effect in the model substantially reduced the direct relationship between depression and cardiovascular hospitalisations. BMI and waist-to-hip ratio accounted for indirect effects of 7.7 and 10.4 %, respectively. Inflammatory markers partly explain the association between depression and cardiovascular events, although other shared factors also likely contribute.

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Cohort Profile: The Hunter Community Study

Cited by 101 publications

References 27 publications

Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence

The Association of the 4q25 Susceptibility Variant for Atrial Fibrillation With Stroke Is Limited to Stroke of Cardioembolic Etiology

The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations

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