Cohort Profile: The Hoorn Studies

Rutters, Femke; Nijpels, Giel; Elders, Petra; Stehouwer, Coen D. A.; Heijden, Amber A. van der; Groeneveld, Lenka; Hart, Leen M ’t; Dekker, Joost; Beulens, Joline W.J.

doi:10.1093/ije/dyx227

Cited by 28 publications

(52 citation statements)

References 32 publications

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“…We harmonized data from the Hoorn Study (HS) (n = 2484) and The New Hoorn Study (NHS) (n = 2807) cohorts. Both cohorts were similar in design, population characteristics, and questionnaires, and are described in detail elsewhere [12]. In short, participants from the general population were recruited between 1989 and 1992 for the HS and between 2006 and 2007 for the NHS.…”

Section: Methodsmentioning

confidence: 99%

Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes

et al. 2019

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Purpose In this study, we investigated the association between adherence to the Dutch Healthy Diet index 2015 (DHD15-index) and incidence of prediabetes (preT2D) and Type 2 Diabetes (T2D) in a representative sample for the general Dutch population. Methods Two prospective cohort studies, The Hoorn and The New Hoorn Study, were used for data analyses. In total, data from 2951 participants without diabetes at baseline (mean age 56.5 ± 7.5 years; 49.6% male) were harmonized. Baseline dietary intake was assessed with validated Food Frequency Questionnaires and adherence to the DHD15-index was calculated (range 0–130). PreT2D and T2D were classified according to the WHO criteria 2011. Poisson regression was used to estimate prevalence ratios between participant scores on the DHD15-index and preT2D and T2D, adjusted for follow-up duration, energy intake, socio-demographic, and lifestyle factors. Change in fasting plasma glucose levels (mmol/L) over follow-up was analysed using linear regression analyses, additionally adjusted for baseline value. Results During a mean follow-up of 6.3 ± 0.7 years, 837 participants developed preT2D and 321 participants developed T2D. The highest adherence to the DHD15-index was significantly associated with lower T2D incidence [model 3, PR T3vsT1 : 0.70 (0.53; 0.92), p trend = 0.01]. The highest adherence to the DHD15-index pointed towards a lower incidence of preT2D [PR T3vsT1 : 0.87 (0.74; 1.03), p trend = 0.11]. Higher adherence to the DHD15-index was not associated with change in fasting plasma glucose levels [ β 10point : − 0.012 (− 0.034; 0.009)mmol/L]. Conclusion The present study showed that the highest compared to the lowest adherence to the DHD15-index was associated with a lower T2D incidence, and pointed towards a lower incidence of preT2D. These results support the benefits of adhering to the guidelines in T2D prevention. Electronic supplementary material The online version of this article (10.1007/s00394-019-02064-8) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes

et al. 2019

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“…The Hoorn and Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) studies are observational, prospective cohort studies on determinants and (cardiovascular) complications of type 2 diabetes mellitus (T2DM). The original Hoorn study was executed in 2484 randomly selected residents of Hoorn between 1989 and 1992 . Between 2000 and 2001, follow‐up measurements were conducted in a subset (n = 822) of participants, which were used for the current study.…”

Section: Methodsmentioning

confidence: 99%

“…The original Hoorn study was executed in 2484 randomly selected residents of Hoorn between 1989 and 1992 . Between 2000 and 2001, follow‐up measurements were conducted in a subset (n = 822) of participants, which were used for the current study. The CODAM study was performed in 574 participants of the Dutch Monitoring Project for Cardiovascular Diseases (MORGEN) and its predecessor with an elevated risk of T2DM .…”

Section: Methodsmentioning

confidence: 99%

“…Both variants were in Hardy‐Weinberg equilibrium ( P = .93 for rs1260326 [minor allele frequency: 38.5%] and P = .16 for rs738409 [minor allele frequency: 24.2%] in individuals with NGM). Plasma was drawn after an overnight fast for measurement of among others alanine aminotransferase (ALT), triglycerides, sE‐selectin and sVCAM levels, as described before . Plasma levels of sE‐selectin and sVCAM were determined using a MSD multiplex assay (Meso Scale Diagnostics), which is comparable to single‐biomarker methods, such as ELISA, but could result in a different absolute concentration .…”

Section: Methodsmentioning

confidence: 99%

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The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

Simons

Bijnen

Wouters

et al. 2020

Liver International

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Abbreviations: AFLD, alcoholic fatty liver disease; CODAM, Cohort on Diabetes and Atherosclerosis Maastricht; CVD, cardiovascular disease; GCKR, glucokinase regulatory protein; IGM, impaired glucose metabolism; NAFLD, nonalcoholic fatty liver disease; NAS, NAFLD activity score; NASH, nonalcoholic steatohepatitis; NGM, normal glucose metabolism; PNPLA3, patatin-like phospholipase domain-containing protein 3; sE-selectin, soluble E-selectin; sVCAM-1, soluble vascular cell adhesion molecule-1; T2DM, type 2 diabetes; VAT, visceral adipose tissue. AbstractBackground & Aims: Plasma soluble E-selectin (sE-selectin) is a frequently used biomarker of systemic endothelial dysfunction. The present study explored the relationship between nonalcoholic fatty liver disease (NAFLD) and plasma sE-selectin levels. Methods:Expression of E-selectin in liver, visceral adipose tissue (VAT) and muscle was studied in relation to plasma sE-selectin in severely obese individuals (n = 74).The course of hepatic E-selectin expression in relation to hepatic steatosis and inflammation was examined in C57BL/6J LDLR −/− mice on a Western-type diet. The relationship between biomarkers of NAFLD, that is, plasma aminotransferase (ALT) and

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“…Recruitment, enrolment and eligibility: The derivations of Cohort 1 and Cohort 2 are shown in Figure 1. The sampling-frame for Cohort 1 was derived from four existing prospective cohort studies: Metabolic Syndrome in Men (METSIM) study (Finland) [8]; Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) [9], Hoorn Meal Study (HMS), and New Hoorn Study (NHS) [10] (Netherlands); Health2010 [11], Health2006 [12], Danish Study of Functional Disorders (DanFunD) [13], and Gut, Grain and Greens (GGG) [14] studies (Denmark); Malmö Diet and Cancer (MDC) study (Sweden) [15]. Participants for Cohort 2 were identified through general practice and other registries, as described previously [7].…”

Section: Methodsmentioning

confidence: 99%

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Koivula

Forgie

Kurbasic

et al. 2018

Preprint

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Abstract/SummaryBackground and aims:Understanding the aetiology, clinical presentation and prognosis of type 2 diabetes (T2D) and optimizing its treatment might be facilitated by biomarkers that help predict a person’s susceptibility to the risk factors that cause diabetes or its complications, or response to treatment. The IMI DIRECT (Diabetes Research on Patient Stratification) Study is a European Union (EU) Innovative Medicines Initiative (IMI) project that seeks to test these hypotheses in two recently established epidemiological cohorts. Here, we describe the characteristics of these cohorts at baseline and at the first main follow-up examination (18-months).Materials and methods:From a sampling-frame of 24,682 European-ancestry adults in whom detailed health information was available, participants at varying risk of glycaemic deterioration were identified using a risk prediction algorithm and enrolled into a prospective cohort study (n=2127) undertaken at four study centres across Europe (Cohort 1: prediabetes). We also recruited people from clinical registries with recently diagnosed T2D (n=789) into a second cohort study (Cohort 2: diabetes). The two cohorts were studied in parallel with matched protocols. Endogenous insulin secretion and insulin sensitivity were modelled from frequently sampled 75g oral glucose tolerance (OGTT) in Cohort 1 and with mixed-meal tolerance tests (MMTT) in Cohort 2. Additional metabolic biochemistry was determined using blood samples taken when fasted and during the tolerance tests. Body composition was assessed using MRI and lifestyle measures through self-report and objective methods.Results:Using ADA-2011 glycaemic categories, 33% (n=693) of Cohort 1 (prediabetes) had normal glucose regulation (NGR), and 67% (n=1419) had impaired glucose regulation (IGR). 76% of the cohort was male, age=62(6.2) years; BMI=27.9(4.0) kg/m2; fasting glucose=5.7(0.6) mmol/l; 2-hr glucose=5.9(1.6) mmol/l [mean(SD)]. At follow-up, 18.6(1.4) months after baseline, fasting glucose=5.8(0.6) mmol/l; 2-hr OGTT glucose=6.1(1.7) mmol/l [mean(SD)]. In Cohort 2 (diabetes): 65% (n=508) were lifestyle treated (LS) and 35% (n=271) were lifestyle + metformin treated (LS+MET). 58% of the cohort was male, age=62(8.1) years; BMI=30.5(5.0) kg/m2; fasting glucose=7.2(1.4)mmol/l; 2-hr glucose=8.6(2.8) mmol/l [mean(SD)]. At follow-up, 18.2(0.6) months after baseline, fasting glucose=7.8(1.8) mmol/l; 2-hr MMTT glucose=9.5(3.3) mmol/l [mean(SD)].Conclusion:The epidemiological IMI DIRECT cohorts are the most intensely characterised prospective studies of glycaemic deterioration to date. Data from these cohorts help illustrate the heterogeneous characteristics of people at risk of or with T2D, highlighting the rationale for biomarker stratification of the disease - the primary objective of the IMI DIRECT consortium.Abbreviations:ASATAbdominal subcutaneous adipose tissueDIRECTDiabetes Research on Patient StratificationEUEuropean UnionMMTTMixed-meal tolerance testMRIMagnetic resonance imaginghpfVMHigh-pass filtered vector magnitudeIAATIntra-abdominal adipose tissueIGRImpaired glucose regulationIMIInnovative Medicines InitiativeMEmultiechoNGRNormal glucose regulationOGTTOral glucose tolerance testPAPhysical activityTAATTotal abdominal adipose tissueT2DType 2 Diabetes

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Cohort Profile: The Hoorn Studies

Cited by 28 publications

References 32 publications

Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes

Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes

The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

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