Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study

Braun, Joseph M.; Kalloo, Geetika; Chen, Aimin; Dietrich, Kim N.; Liddy-Hicks, Stacey; Morgan, S. Philip; Xu, Yingying; Yolton, Kimberly; Lanphear, Bruce P.

doi:10.1093/ije/dyw006

Cited by 116 publications

(113 citation statements)

References 31 publications

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“…Urinary BPA concentrations during pregnancy and childhood had a 1.8 to 3.2 order of magnitude range. The demographic composition of the participants who completed follow-up at age 8 years was similar to the overall cohort (Braun et al 2016). …”

Section: Resultsmentioning

confidence: 81%

“…We previously described eligibility criteria and participant recruitment and follow-up (Braun et al 2016). In summary, eligibility requirements included that women were ≥ 18 years of age, at 13–19 weeks of gestation, living in the Cincinnati, Ohio area in a home built before 1978, not on medications for thyroid disorders or seizures, planning to continue prenatal care and deliver at the collaborating clinics and hospitals, planning to live in the Cincinnati area for the next year, fluent in English, and had no diagnosis of diabetes, bipolar disorder, schizophrenia, HIV infection, or cancer that resulted in radiation treatment or chemotherapy.…”

Section: Methodsmentioning

confidence: 99%

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Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability

Stacy

Papandonatos

Calafat

et al. 2017

Environment International

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Background Early life BPA exposure could affect neurobehavior, but few studies have investigated whether there are developmental periods when the fetus or child is more vulnerable to these potential effects. Objectives We explored windows of vulnerability to BPA exposure in a multiethnic cohort of 228 mothers and their children from Cincinnati, Ohio. Methods We measured urinary BPA concentrations at up to two prenatal and six postnatal time points from the 2nd trimester of pregnancy until the child was age 8 years. At age 8 years, we administered the Behavioral Assessment System for Children-2 (BASC-2), Behavior Rating Inventory of Executive Function, and Wechsler Intelligence Scale for Children-IV. We estimated covariate-adjusted differences in composite scores from each instrument using a multiple informant model designed to identify heightened windows of vulnerability. Results Among all children, there was not strong evidence that the associations between BPA and neurobehavior varied by the timing of exposure (Visit × BPA p-values=0.16). However, child sex modified the associations of repeated BPA measures with BASC-2 scores (Visit × Sex × BPA p-values=0.02–0.23). For example, each 10-fold increase in prenatal BPA was associated with more externalizing behaviors in girls (β=6.2, 95% CI: 0.8, 11.6), but not boys (β=−0.8, 95% CI: −5.0, 3.4). In contrast, a 10-fold increase in 8-year BPA was associated with more externalizing behaviors in boys (β=3.9, 95% CI: 0.6, 7.2), but not girls (β=0.3, 95% CI: −3.5, 4.1). Conclusions We found that sex-dependent associations between BPA and child neurobehavior may depend on the timing of BPA exposure.

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Section: Resultsmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability

Stacy

Papandonatos

Calafat

et al. 2017

Environment International

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“…Detailed information on enrollment, inclusion criteria, and neurobehavioral assessments are described by Braun et al (2016). The HOME Study included 390 singleton births at delivery and completed multiple postnatal follow-up visits up to age 8 years.…”

Section: Methodsmentioning

confidence: 99%

Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years

Vuong

Yolton

Xie

et al. 2017

Environmental Research

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Background Prenatal polybrominated diphenyl ether (PBDE) exposure has been associated with decrements in IQ and increased attention deficit/hyperactivity disorder related behaviors in children; however, data are limited for the role of postnatal exposures. Objectives We investigated the association between a series of childhood PBDE concentrations and Full-Scale Intelligence Quotient (FSIQ) and externalizing problems at 8 years. Methods We used data from 208 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort. Child serum PBDEs were measured at 1, 2, 3, 5, and 8 years; missing serum PBDE concentrations were estimated via multiple imputation. The Wechsler Intelligence Scales for Children-IV and the Behavior Assessment System for Children-2 was used to assess intelligence and externalizing behavior, respectively, in children at 8 years. We used multiple informant models to estimate associations between repeated lipid-adjusted PBDEs and child neurobehavior and to test for windows of susceptibility. Results Postnatal exposure to PBDE congeners (-28, -47, -99, -100, and -153) at multiple ages was inversely associated with FSIQ at 8 years. For instance, a 10-fold increase in BDE-153 concentrations at 2, 3, 5, and 8 years were all related to lower FSIQ at age 8 (β for 3 years: −7.7-points, 95% CI −12.5, −2.9; β for 8 years: −5.6-points, 95% CI −10.8, −0.4). Multiple PBDE congeners at 8 years were associated with increased hyperactivity and aggressive behaviors at 8 years. Conclusions Postnatal PBDE exposure was associated with decrements in FSIQ and increases in hyperactivity and aggressive behaviors.

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“…Details regarding inclusion and exclusion criteria, measurement of chemicals, and neurobehavioral assessments can be found elsewhere (Braun et al, 2017). The present study included 214 singletons who had measured PBDEs (prenatal and postnatal) and a CPT-II assessment at 8 years.…”

Section: Methodsmentioning

confidence: 99%

Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children

Vuong

Yolton

Poston

et al. 2017

Neurotoxicology and Teratology

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Exposure to polybrominated diphenyl ethers (PBDEs) during fetal development may be associated with deficits in attention and impulse control. However, studies examining postnatal PBDE exposures and inattention and impulsivity have been inconsistent. Using data from 214 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort with enrollment from 2003–2006 in the Greater Cincinnati Area, we investigated the relationship of both prenatal and postnatal PBDE exposures with attention and impulse control. Serum PBDEs were measured at 16±3 weeks of gestation and during childhood at 1, 2, 3, 5, and 8 years. We assessed children’s attention and impulse control using the Conners’ Continuous Performance Test-Second Edition (CPT-II) at 8 years. We used multiple informant models to estimate associations of repeated PBDE measures with inattention and impulsivity. There was a pattern of associations between PBDEs and poorer performance on CPT-II measures of attention. For BDE-153, adverse associations extended to exposures at preschool and kindergarten ages; ten-fold increases in exposure were associated with higher omission errors (BDE-153 at 3 years: β=4.0 [95% CI: −2.4, 10.4]; at 5 years: β=4.6 [95% CI: −2.8, 12.0]; at 8 years: β=4.1 [95% CI: −3.4, 11.5]). Longer hit reaction times, indicated by the exponential part of the hit reaction curve, were also observed with 10-fold increases in BDE-153 during the prenatal period and throughout childhood (Prenatal: β=15.0 milliseconds (ms) [95% CI: −15.8, 45.8]; 5 years: β=20.6 ms [95% CI: −20.8, 61.9]; 8 years: β=28.6 ms [95% CI: −12.1, 69.4]). Significant impairment in discriminability, as indicated by detectability (d′), between targets and non-targets was also noted with 5 and 8-year PBDE concentrations. Associations between PBDEs and inattention significantly differed by child sex, with males performing more poorly than females with regard to omission errors and measures of reaction times. Collectively, these results do not strongly support that PBDEs are associated with poorer impulse and attention control among 8 year old children. However, there may be a possible relationship between prenatal and concurrent PBDEs and inattention, which requires additional research.

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Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study

Cited by 116 publications

References 31 publications

Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability

Early life bisphenol A exposure and neurobehavior at 8 years of age: Identifying windows of heightened vulnerability

Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years

Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children

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