Cohort Profile: The FinnBrain Birth Cohort Study (FinnBrain)

Karlsson, Lena; Tolvanen, Mimmi; Scheinin, Noora M.; Uusitupa, Henna-Maria; Korja, Riikka; Ekholm, Eeva; Tuulari, Jetro J.; Pajulo, Marjukka; Huotilainen, Minna; Paunio, Tiina; Karlsson, Hasse

doi:10.1093/ije/dyx173

Cited by 193 publications

(202 citation statements)

References 63 publications

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“…The study will continue for several decades and combine questionnaire data, biological samples and registry data. Details of the cohort profile and methods used are presented in Karlsson et al…”

Section: Methodsmentioning

confidence: 99%

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Association of depression and anxiety with different aspects of dental anxiety in pregnant mothers and their partners

Lahti

Tolvanen

Humphris

et al. 2019

Comm Dent Oral Epid

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Objectives The aim was to confirm the factor structure of Modified Dental Anxiety Scale (MDAS) and to investigate whether the association of these factors with general anxiety and depression varied across gender. Methods The FinnBrain Birth Cohort Study (http://www.finnbrain.fi) data from the first collection point at gestational week 14 were used. Of the invited participants (n = 5790), 3808 (66%) expectant mothers and 2623 fathers or other partners of the mother agreed to participate, and 3095 (81.3%) mothers and 2011 (76.7%) fathers returned the self‐report questionnaire. Dental anxiety was measured with the MDAS, general anxiety symptoms with Symptom Checklist‐90 (anxiety subscale) and depressive symptoms with the Edinburgh Postnatal Depression Scale. Multiple group confirmatory factor analysis (MGCFA) was conducted to test the equivalence of the factor structure and multiple group SEM (MGSEM) to test the configural invariance (unconstrained model) and metric invariance (structural weights model), across genders. Results Of those consenting, 3022 (98%) women and 1935 (96%) men answered the MDAS. The MGCFA indicated good convergent validity for the two‐factor model for MDAS, but somewhat low discriminant validity (factors demonstrated 72% shared variance). The MDAS items loaded clearly higher for the assigned factor than to the other factor (differences in loadings >0.2), indicating that the 2‐factor model has merit. According to the final MGSEM model, anxiety symptoms were directly related to anticipatory dental anxiety, but not to treatment‐related dental anxiety. Conclusions When assessing dental anxiety with MDAS, considering also its two factors may help clinicians in understanding the nature of patient's dental anxiety.

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Section: Methodsmentioning

confidence: 99%

“…For EPDS, a sum score (scale 0‐30) was used. Mean levels for EPDS and SCL‐90 are presented in Karlsson et al If there were ≤ 30% missing items for the MDAS, SCL‐90 or EPDS, they were replaced with the mean value of other items of that respondent. Of the background information, we used age in years and gender.…”

Section: Methodsmentioning

confidence: 99%

Association of depression and anxiety with different aspects of dental anxiety in pregnant mothers and their partners

Lahti

Tolvanen

Humphris

et al. 2019

Comm Dent Oral Epid

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“…The participants, all Caucasian, for this study ( n = 363 mother‐infant dyads) were drawn from an ongoing FinnBrain Birth Cohort Study ( N = 3,808 families), a general population pregnancy cohort located in South‐Western Finland. The cohort population represents well the source population of Finland (Karlsson et al., ). Recruitment for the whole cohort took place at the first ultrasound visit at the gestational week (gwk) 12 at three maternal welfare clinics that performed ultrasound scans for the women giving birth at Turku University Hospital in the Southwest Finland Hospital District and the Åland Islands in Finland between December 2011 and April 2015.…”

Section: Methodsmentioning

confidence: 99%

Maternal Depressive Symptoms During the Pre‐ and Postnatal Periods and Infant Attention to Emotional Faces

et al. 2018

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We examined how infants’ attentional disengagement from happy, fearful, neutral, and phase‐scrambled faces at 8 months, as assessed by eye tracking, is associated with trajectories of maternal depressive symptoms from early pregnancy to 6 months postpartum (decreasing n = 48, increasing n = 34, and consistently low symptom levels n = 280). The sample (mother–infant dyads belonging to a larger FinnBrain Birth Cohort Study) was collected between 5/2013–6/2016. The overall disengagement probability from faces to distractors was not related to maternal depressive symptoms, but fear bias was heightened in infants whose mothers reported decreasing or increasing depressive symptoms. Exacerbated attention to fearful faces in infants of mothers with depressive symptoms may be independent of the timing of the symptoms in the pre‐ and postnatal stages.

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“…The FinnBrain Birth Cohort Study investigates the effects of prenatal and early-life stress exposure on child health (Karlsson et al, 2018). Within the main Cohort, a nested case-control study, called the Focus Cohort, was established to enable comparisons between subjects exposed to different types of prenatal PD with their non-exposed controls (Supplementary Material).…”

Section: Definition Of Maternal Psychological Distress During Pregnancymentioning

confidence: 99%

Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants

Korhonen¹,

Kortesluoma²,

Lukkarinen³

et al. 2019

Psychoneuroendocrinology

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Introduction: Prenatal exposure to maternal psychological distress (PD) may have programming effects on the fetus/infant hypothalamic-pituitary-adrenal (HPA) axis and subsequently on the development of the fetus' immune function. Therefore, our aim was to study whether prenatal exposure to PD is related to early infant HPA axis reactivity in the context of a subclinical rhinovirus infection that challenges infants HPA axis postnatally. Methods: This study included 336 10-week-old infants from the nested case control Focus Cohort of the FinnBrain Birth Cohort Study. The outcome was infant HPA axis reactivity in a stress test. The acute stressor comprised of pediatric examination with venipuncture and nasal swabs for virus assessment. Saliva cortisol samples were collected at 5 time points: baseline, 0, 15, 25 and 35 min after the stressor. HPA axis reactivity was defined by the cumulative post-stressor cortisol concentration. Results: HPA axis reactivity was blunted in the PD/rhinovirus + group compared to the average of control/ rhinovirus+, PD/rhinovirus-, and control/rhinovirus-groups (difference: 14.7 ln [nmol/L] × min, 95% confidence interval 3.8-25.6, p = .008). HPA axis reactivity was significantly blunted only in boys with rhinovirus detected when separately tested for boys and girls (p = .04). Conclusion: Our finding of PD-exposed rhinovirus-positive infants having blunted cortisol secretion gives rise to a hypothesis that maternal PD during pregnancy influences infant HPA axis functioning and the functioning of the immune system. Future studies are needed to test whether this suppression of the HPA axis that co-occurs with rhinovirus infection associates with later disease development (e.g., asthma). Prenatal exposure to maternal PD may affect the development of the fetus/infant hypothalamic-pituitary-adrenal (HPA) axis (O'Donnell and Meaney, 2017). Lymphoid organs, and particularly the thymus, display a markedly elevated expression of glucocorticoid receptors during extra-uterine life (Merlot et al., 2008). In transgenic mice with impaired https://doi.Abbreviations: AUC, area under the curve above/below baseline; EPDS, Edinburgh postnatal depression scale; CI, confidence interval; gwk, gestational week; HPA, hypothalamic-pituitary-adrenal; PCR, polymerase chain reaction; PD, psychological distress; PRAQ-R2, pregnancy-specific anxiety questionnaire-revised 2; SCL-90, symptom checklist-90, anxiety scale; SSRIs, selective serotonin reuptake inhibitors ⁎

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Cohort Profile: The FinnBrain Birth Cohort Study (FinnBrain)

Cited by 193 publications

References 63 publications

Association of depression and anxiety with different aspects of dental anxiety in pregnant mothers and their partners

Association of depression and anxiety with different aspects of dental anxiety in pregnant mothers and their partners

Maternal Depressive Symptoms During the Pre‐ and Postnatal Periods and Infant Attention to Emotional Faces

Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants

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