Cohort Profile: The European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Czech Republic

Piler, Pavel; Kandrnal, Vít; Kukla, Lubomír; Andrýsková, Lenka; Švancara, Jan; Jarkovský, Jiří; Dušek, Ladislav; Pikhart, Hynek; Bobák, Martin; Klánová, Jana

doi:10.1093/ije/dyw091

Cited by 66 publications

(74 citation statements)

References 31 publications

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“…At the beginning of the Czech ELSPAC study, the population from which our cohort was drawn was broadly representative of the entire Czech Republic 24. Although we included only approximately 70% of original study sample in our analysis, the prevalence of asthma reported in the ELSPAC study was found to be in accordance with the prevalence of asthma in Czech children in the 1990s35 but these data are lower than the data presented by the International Study of Asthma and Allergies in Childhood for Northern and Eastern Europe (prevalence of asthma in children aged 6–7 years, male 9.9 and female 7.5) 36.…”

Section: Discussionmentioning

confidence: 99%

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

Piler

Švancara

Kukla

et al. 2018

J Epidemiol Community Health

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Section: Discussionmentioning

confidence: 99%

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

Piler

Švancara

Kukla

et al. 2018

J Epidemiol Community Health

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“…The study sample of 3,701 nulliparous as well as multiparous women completed self-reported questionnaires during pregnancy (predominantly week 20 +/− 2 weeks), at 6 weeks and 6 months after birth. An earlier publication describing the cohort profile shows that those included in the ELSPAC-CZ study do not differ substantially from the whole target population in terms of available demographic characteristics 29 . The questionnaires included the Edinburgh Postnatal Depression Scale (EPDS), specific questions to confirm stress urinary incontinence symptoms, a socio-economic status questionnaire, and a general health questionnaire.…”

Section: Study Population Data For This Analysis Were Derived From Imentioning

confidence: 99%

Association between Stress Urinary Incontinence and Depressive Symptoms after Birth: the Czech ELSPAC Study

Jurášková

Piler

Kukla

et al. 2020

Sci Rep

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The study objectives were to (1) identify risk factors related to stress urinary incontinence (SUI) and postnatal depression (PD) after birth, and (2) investigate both possible directions of association between SUI and PD in population-based sample of Czech mothers. 3,701 nulliparous and multiparous women completed the self-reported questionnaires at 6 weeks and 6 months after birth and were included into the analyses of this prospective cohort study. Unadjusted and adjusted logistic regressions examined relationship between SUI a PD accounting for range of other risk factors. During the first 6 months after birth, 650 mothers (17.6%) developed SUI and 641 (17.3%) displayed signs of PD. The mode of delivery, parity and higher BMI were associated with SUI. The rate of PD symptoms was higher in mothers with positive history of prenatal depression, and in divorced or widowed mothers. Both conditions were associated with worse self-reported health, back pain and stop-smoker status. initially, SUI at 6 weeks was slightly, but significantly associated with onset of PD at 6 months (OR 1.51, 95% CI 1.02-2.23) while PD at 6 weeks was not significantly related to new cases of SUI at 6 months (OR 1.48, 95% CI 0.91-2.39). After full adjustment these OR reduced to 1.41 and 1.38 (both non-significant), respectively. SUi and pD are common conditions in women postpartum that share some risk factors. Our study suggests that both directions of their relationship are possible although a larger study is needed to confirm our findings.Urinary incontinence is a commonly experienced health problem in women after delivery. Its prevalence ranges between 18 and 34% 1 . Multiple studies showed that a vaginal delivery is the most significant postpartum urinary incontinence contributor 2 . Other suggested risk factors included increased maternal age, body mass index and parity 3 . In most cases urinary incontinence regresses spontaneously or after rehabilitation of the pelvic floor muscles. However, a substantial number of women with postpartum urinary incontinence are affected in the long term 4 . Postpartum urinary incontinence together with other health related problems such as tiredness, back pain, sexual problems, and relationship difficulties may contribute to the development of depressive symptoms 5 .Transient mood disorders after birth are common but usually subside relatively quickly without any long term adverse effects 6 . Postpartum depression, on the other hand, is more severe mood disorder with a potential long term effect on mothers´ quality of life 7 . Its prevalence ranges from 5.2% to 13.0% in developed countries 8 and can reach up to 20% in mothers from low and middle income countries 9 . In addition, some authors suggested that the rates reported in some studies were underestimated and would be higher if a standardized screening tool for depression in mothers after birth had been applied 10 . The main covariates for postnatal depression include

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“…A total of 388 unrelated Caucasian children (203 boys and 185 girls), aged 13-15 years, selected from the prospective European Longitudinal Study of Pregnancy and Childhood (ELSPAC) Brno study comprising over 7,000 children and their families [ELSPAC, 1989;Piler et al, 2016], were investigated. Of the whole ELSPAC set, 900 individuals were randomly selected and invited to participate in the study of oral health.…”

Section: Subjectsmentioning

confidence: 99%

Vitamin D Receptor<b><i> Taq</i></b>I Gene Polymorphism and Dental Caries in Czech Children

Hollá¹,

Linhartová²,

Kaštovský³

et al. 2016

Caries Res

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Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method. Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.

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Cohort Profile: The European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Czech Republic

Cited by 66 publications

References 31 publications

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

Association between Stress Urinary Incontinence and Depressive Symptoms after Birth: the Czech ELSPAC Study

Vitamin D Receptor<b><i> Taq</i></b>I Gene Polymorphism and Dental Caries in Czech Children

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