Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

Yu, Rongjun; Sun, Ye; Ye, Kaisy Xinhong; Feng, Qiushi; Lim, Su Lin; Mahendran, Rathi; Cheah, Irwin K.; Foo, Roger; Chua, Ru Yuan; Gwee, Xinyi; Loh, Marie; Sarmugam, Rani; Khine, Wei Wei Thwe; Chao, Yin Xia; Larbi, Anis; Lee, Yuan Kun; Kumar, Alan Prem; Kennedy, Brian K.; Kua, Ee Heok; Feng, Lei

doi:10.18632/aging.104051

Cited by 9 publications

(10 citation statements)

References 44 publications

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“…The study protocol had been prospectively approved by the National University of Singapore Institutional Review Board (NUS IRB-Reference Code: B-14-110), and a priori registered at ClinicalTrials.gov (NCT02286791), a service of the United States National Institute of Health. We recruited our study participants from a larger on-going study, DaHA based at TaRA@JP [ 41 ]. It is a community-based research center established by the NUS Psychological Medicine department and located in a shopping mall, in the western part of Singapore.…”

Section: Methods and Designmentioning

confidence: 99%

“…The study was conducted in accordance with the Declaration of Helsinki. As shown in Figure 1 , the participants were recruited from the Diet and Healthy Ageing Study (DaHA) (NUS-IRB Reference No:10-517) [ 41 ], a longitudinal cohort study based at the Training and Research Academy at Jurong Point (TaRA@JP). The research nurses, research assistants, and T.K.S.N.…”

Section: Methods and Designmentioning

confidence: 99%

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Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes

Feng

Fam

et al. 2021

IJERPH

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Background: With an aging population, developing non-pharmacological interventions (NPIs) to delay dementia has become critical. Apart from cognitive decline, dementia is associated with multiple pathophysiology, including increased oxidative stress, dysregulated gene expressions, cytokine, neurotrophin, and stress markers, telomere shortening, and deteriorations in brain connectivity. Although mindfulness practices have been proposed to ameliorate these biological changes, no empirical studies were conducted. We thus aimed to investigate the effects of mindfulness awareness practice (MAP) to prevent cognitive decline and improve peripheral biomarkers in community-dwelling older adults diagnosed with mild cognitive impairment (MCI). Methods/Design: This was a single-blinded and parallel-group randomized controlled trial with two arms (intervention and active control arms), conducted over nine months. A total of 60 consenting community-dwelling older adults diagnosed with MCI were planned to be randomized in a 1:1 ratio to either the MAP or the Health Education Program (HEP). Interventions were performed weekly for the initial 12 weeks, and monthly for the subsequent six months. Outcome measures were assessed at baseline, 3-month, and 9-month post-intervention by blinded assessors. Primary outcomes were neurocognitive tests, comprehensive peripheral biomarkers, and brain imaging scans. Secondary outcomes included basic health screening measures, affective symptoms, and measures of physical functions. Linear-mixed models were used to examine the effects of MAP on these outcome measures. Significance: This is the first randomized controlled trial to systematically investigate the effects of a mindfulness intervention in improving cognitive functions and various biomarkers in community-dwelling older adults diagnosed with MCI. Our findings have the potential to inform mindfulness intervention as a novel approach to delay dementia.

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Section: Methods and Designmentioning

confidence: 99%

Section: Methods and Designmentioning

confidence: 99%

Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes

Feng

Fam

et al. 2021

IJERPH

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“…[81] Based on the above evidence, national guidelines for healthy dietary patterns have been established by government agencies and scientific Societies worldwide. Examples include: the "2010 Dietary Guidelines for Americans," "Nutrition Facts labels," and "Healthy People 2020" have been developed in the US [82,83] ; the Canadian Hypertension Education Program Guidelines (2016), [84] the Task Force for the management of dyslipidemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS), [23] the "Diabetes prevention program of healthy Japan 21," "WHO Healthy City Initiative in Japan," "Current status and issues concerning Health Japan 21," [85,86] the Seoul Metabolic Syndrome Management program in South Korea, [87] the Diet and Healthy Aging (DaHA) study and Dietary guidelines in Singapore, [88,89] Chinese guidelines for the management of hypertension (2010), [90] and consensus dietary guidelines for healthy living and prevention of obesity, the metabolic syndrome, diabetes, and related disorders in Asian Indians. [91] Among other population approaches, routine nutrition screening and consultation have been included in medical insurance in the US, with comprehensive management and follow-up programs.…”

Section: Nutrition Health and Disease: A Fundamental Relationshipmentioning

confidence: 99%

Nutritional care is the first-line therapy for many conditions

Hu,

Barazzoni,

Shi

2023

Precision Nutrition

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“…The diet and healthy aging (DaHA) is a multi-ethnic, community-based longitudinal follow-up cohort study, described extensively elsewhere (Yu et al, 2020). The baseline recruitment period was from 2014 to 2017.…”

Section: Longitudinal Follow-up Cohort (N = 991)mentioning

confidence: 99%

A 5‐year community program in Singapore to prevent cognitive decline

Feng

Chua

et al. 2022

Asia-Pacific Psychiatry

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Introduction: There is a scarcity of naturalistic follow-up studies on cognitive stimulating activities (CSAs), particularly in a real-world setting and over long-term.We thus investigated a pooled novel CSA intervention to prevent cognitive decline amongst community-dwelling older adults without dementia.Methods: Nested within a community-based longitudinal follow-up cohort study of community-dwelling and multi-ethnic older adults (N = 991), a subset of the cohort (n = 264) underwent four single-blinded randomized controlled trials involving four novel CSAs, including mindfulness, horticulture, art therapy, and choral singing. At the cohort's 5-year follow-up, we examined if involvements in the CSAs improved cognition, compared to controls (n = 727). The primary outcomes were changes in global cognition and specific cognitive domain scores measured by the mini-mental state examination (MMSE). Exploratory subgroup analyses stratified by baseline cognitive status and the number of CSAs were also conducted.Results: Compared to the control group, there was a small improvement in the CSA group on the total MMSE score (d = 0.108) and MMSE-immediate recall score (d = 0.199). Furthermore, subgroup analyses revealed medium effect sizes of improvements (d = 0.420) in cognitive domains in mild cognitive impairment (MCI) (vs. cognitively healthy) and those involved in two CSAs (vs. one CSA).Discussion: In summary, a CSA intervention improved cognition. MCI and those involved in two CSAs gained greater benefits from the CSAs. These sustained improvements in cognitive functions could have a significant impact on delaying or preventing dementia.

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Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

Cited by 9 publications

References 44 publications

Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes

Mindfulness Awareness Practice (MAP) to Prevent Dementia in Older Adults with Mild Cognitive Impairment: Protocol of a Randomized Controlled Trial and Implementation Outcomes

Nutritional care is the first-line therapy for many conditions

A 5‐year community program in Singapore to prevent cognitive decline

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