Cohort Profile: The Danish HIV Cohort Study

Obel, Niels; Engsig, Frederik Neess; Rasmussen, Line Dahlerup; Larsen, Mads Langager; Omland, Lars Haukali; Sørensen, Henrik Toft

doi:10.1093/ije/dyn192

Cited by 109 publications

(68 citation statements)

References 22 publications

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“…Study subjects were identified from the Danish HIV Cohort Study (48) and by physician referral. Inclusion criteria were (i) HIV-1 enzymelinked immunosorbent assay (ELISA) reactive and Western blot positive, (ii) at least 3 HIV-RNA test results available without cART, (iii) a span of at least 1 year between the first and the last HIV-RNA test results, and (iv) no test showing Ͼ50 HIV-1 RNA copies/ml.…”

Section: Methodsmentioning

confidence: 99%

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

Mens

Kearney

Wiegand

et al. 2010

J Virol

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Elucidating mechanisms leading to the natural control of HIV-1 infection is of great importance for vaccineWe studied a cohort of 21 HIV-1 controllers with a median level of viremia below 1 copy/ml, followed for a median of 11 years. Less than half of the cohort carried known protective HLA types (B*57/27). By isolating HIV-1 RNA from large volumes of plasma, we amplified single genome sequences of both pro-rt and env longitudinally. This study is the first to document that HIV-1 pro-rt and env evolve in this patient group, albeit at rates somewhat lower than in HIV-1 noncontrollers, in HLA B*57/27-positive, as well as HLA B*57/27-negative, individuals. Viral diversity and adaptive events associated with immune escape were found to be restricted in HIV-1 controllers, suggesting that replication occurs in the face of less overall immune selection.

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Section: Methodsmentioning

confidence: 99%

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

Mens

Kearney

Wiegand

et al. 2010

J Virol

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“…The cohort has been described in detail elsewhere [18,22]. In brief, the study is ongoing, with continuous enrolment of both newly diagnosed individuals and immigrants with HIV infection aged 16 years or older.…”

Section: The Danish Hiv Cohort Study (Dhcs)mentioning

confidence: 99%

Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV‐infected individuals from 1995 to 2007: a nationwide cohort study^*

et al. 2011

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all Danish HIV-infected individuals (n 5 4871) and population controls (n 5 92 116) matched on age and sex were enrolled in a cohort and all cases of SAB were registered. IRs and risk factors were estimated using time-updated Poisson regression analysis. ResultsWe identified 329 cases of SAB in 284 individuals, of whom 132 individuals were infected with HIV and 152 were not [crude IR ratio (IRR) 24.2; 95% confidence interval (CI) 19.5-30.0, for HIV-infected vs. non-HIV-infected individuals]. Over time, IR declined for HIV-infected individuals (IRR 0.40). Injecting drug users (IDUs) had the highest incidence and the smallest decline in IR, while men who have sex with men (MSM) had the largest decline over time. Among HIV-infected individuals, a latest CD4 count o100 cells/mL was the strongest independent predictor of SAB (IRR 10.2). Additionally, HIV transmission group was associated with risk of SAB. MSM were more likely to have hospital-acquired SAB, a low CD4 cell count and AIDS at the time of HIV acquisition compared with IDUs. ConclusionsWe found that the incidence of SAB among HIV-infected individuals declined during the study period, but remained higher than that among HIV-uninfected individuals. There was an unevenly distributed burden of SAB among HIV transmission groups (IDU4MSM). Low CD4 cell count and IDU were strong predictors of SAB among HIV-infected individuals.

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“…More than 98% of the HIV-infected individuals seen at the clinic have been assigned a unique Danish 10-digit personal identification number. The study is described in detail elsewhere [17,18] . From DHCS we identified all HIV-infected individuals who (1) had a Danish personal identification number, (2) attended the clinic during January 1, 2004 to June 1, 2015 and (3) had an mRF performed at Rigshospitalet in this period, and (4) were aged 18 or more at the time of mRF.…”

Section: Study Populationmentioning

confidence: 99%

Agreement between Estimated and Measured Renal Function in an Everyday Clinical Outpatient Setting of Human Immunodeficiency Virus-Infected Individuals

Ahlström¹,

Kjær

Gerstoft³

et al. 2017

Nephron

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Introduction: Estimated renal function (eRF) has been widely implemented as a screening tool in handling human immunodeficiency virus (HIV)-infected individuals. Our primary objective was to investigate the agreement between measured renal function (mRF) and eRF in HIV-infected individuals in an everyday clinical setting. Methods: A single-center study at the HIV-outpatient clinic at Copenhagen University Hospital, Rigshospitalet. Study period from January 1, 2004-June 1, 2015. We included all HIV-infected individuals who had an mRF performed and compared this with eRF assessed with 9 different serum-creatinine-based equations and the eRF reported by the Department of Clinical Biochemistry. We evaluated performance characteristics of the different eRFs, with concordance correlation coefficient, total deviation index, coverage probability, relative accuracy, and Bland Altman plots. We also evaluated whether exposure to (1) rilpivirine, cobicistat, or dolutegravir (RLP/COB/DTG), (2) protease inhibitors (PIs), or (3) tenofovir disoproxil fumarate (TDF) had an impact on agreement. Furthermore, we compared inter- and intra-individual differences between mRF and eRF. Results: Ninety-eight individuals had an mRF performed during the study period. We found that the agreement between mRF and eRF was poor irrespective of the eRF equation. Exposure to RLP/COB/DTG and PIs was not associated with different agreement. Exposure to TDF was associated with statistically significant better agreement for 3 of the evaluated equations. Conclusion: Irrespective of calculation methods, the agreement between mRF and eRF is poor. Surprisingly TDF exposure was associated with a better agreement compared with TDF-unexposed individuals.

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Cohort Profile: The Danish HIV Cohort Study

Cited by 109 publications

References 22 publications

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV‐infected individuals from 1995 to 2007: a nationwide cohort study^*

Agreement between Estimated and Measured Renal Function in an Everyday Clinical Outpatient Setting of Human Immunodeficiency Virus-Infected Individuals

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Cohort Profile: The Danish HIV Cohort Study

Cited by 109 publications

References 22 publications

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

HIV-1 Continues To Replicate and Evolve in Patients with Natural Control of HIV Infection

Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV‐infected individuals from 1995 to 2007: a nationwide cohort study*

Agreement between Estimated and Measured Renal Function in an Everyday Clinical Outpatient Setting of Human Immunodeficiency Virus-Infected Individuals

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Product

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Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV‐infected individuals from 1995 to 2007: a nationwide cohort study^*