Cohort profile: Risk evaluation of cancers in <scp>C</scp>hinese diabetic individuals: a longitudinal (<scp>REACTION</scp>) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)

Bi, Yufang; Lu, Jieli; Wang, Weiqing; Mu, Yiming; Zhao, Jiajun; Liu, Chao; Chen, Lulu; Shi, Lixin; Li, Qiang; Wan, Qin; Wu, Shengli; Yang, Tao; Yan, Li; Liu, Yan; Wang, Guixia; Luo, Zuojie; Tang, Xulei; Chen, Gang; Huo, Yanan; Gao, Zhengnan; Su, Qing; Ye, Zhen; Wang, Youming; Qin, Guijun; Deng, Hongkuan; Yu, Xuefeng; Shen, Feixia; Chen, Li; Zhao, Liebin; Zhang, Jie; Sun, Jichao; Dai, Meng; Xu, Min; Xu, Yu; Chen, Yuhong; Lai, Shenghan; Bloomgarden, Zachary T.; Li, Donghui; Ning, Guang

doi:10.1111/1753-0407.12108

Cited by 155 publications

(131 citation statements)

References 24 publications

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“…The methodology of REACTION study has been described previously 14, 15, 16. Eligible study participants were identified from the local residence registration records and must be age 40 years or older.…”

Section: Methodsmentioning

confidence: 99%

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Lu¹,

et al. 2016

JAHA

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BackgroundChronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear.Methods and ResultsThis study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease (CHD), and 10‐year risk of atherosclerotic cardiovascular diseases (ASCVD) in 239 832 participants from the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD, including reported CHD, stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration (CKD‐EPI) equation was used to calculate eGFR. Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m2), those with decreased eGFR (75–89, 60–74, and <60 mL/min per 1.73 m2) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women (P for trend all <0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m2).ConclusionsEven mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.

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Section: Methodsmentioning

confidence: 99%

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Lu¹,

et al. 2016

JAHA

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“…This study was one part of the baseline survey from the REACTION study, which was a multicenter, prospective cohort study; its primary objective was to demonstrate whether abnormal glucose metabolism was associated with increased risk of cancer in a Chinese population [5, 6]. The study was approved by the ethics committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine.…”

Section: Methodsmentioning

confidence: 99%

Cutoff Point of HbA1c for Diagnosis of Diabetes Mellitus in Chinese Individuals

Wang

Liu

et al. 2016

PLoS ONE

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BackgroundThe purpose of the present study was to find the optimal threshold of glycated hemoglobin (HbA1c) for diagnosis of diabetes mellitus in Chinese individuals.MethodsA total of 8 391 subjects (including 2 133 men and 6 258 women) aged 40–90 years with gradable retinal photographs were recruited. The relationship between HbA1c and diabetic retinopathy (DR) was examined. Receiver operating characteristic (ROC) curves were used to find the optimal threshold of HbA1c in screening DR and diagnosing diabetes.ResultsHbA1c values in patients with DR were significantly higher than in those with no DR. The ROC curve for HbA1c had an area under the curve of 0.881 (95%CI 0.857–0.905; P = 0.000). HbA1c at a cutoff of 6.5% had a high sensitivity (80.6%) and specificity (86.9%) for detecting DR.ConclusionsHbA1c can be used to diagnose diabetes in a Chinese population, and the optimal HbA1c cutoff point for diagnosis is 6.5%.

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“…[10][11][12] During February and March 2012, we investigated 10,028 subjects (6,458 women) 40-90 years of age from four urban communities (one from Jinan city and three from Jining city) in Shandong Province, China. The average response rate was 91.5%.…”

Section: Study Design and Subjectsmentioning

confidence: 99%

Diagnostic Efficiency of Hemoglobin A1c for Newly Diagnosed Diabetes and Prediabetes in Community-Based Chinese Adults Aged 40 Years or Older

Liang

Sun

et al. 2014

Diabetes Technology & Therapeutics

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Background: Europeans and Americans are gradually accepting the hemoglobin A1c (HbA1c) threshold of 6.5% for diagnosing diabetes proposed by the American Diabetes Association, but the cutoff of HbA1c for the Chinese population is unclear. We evaluated the diagnostic efficiency of HbA1c for diagnosing newly diagnosed diabetes and prediabetes in community-based Chinese adults 40 years of age or older. Subjects and Methods: In this study 8,239 subjects (5,496 women) 40-90 years of age underwent HbA1c and oral glucose tolerance test measurement after an overnight fast. Diabetes and prediabetes were defined by the World Health Organization criteria. The area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic efficiency of HbA1c, and the optimal cutoff was defined as the point on the receiver operating characteristic curve with the largest Youden index. Spearman correlation was used for correlation analysis. Results: The prevalence of newly diagnosed diabetes and prediabetes was 10.7% (880/8,239) and 19.0% (1,564/8,239), respectively. Fasting plasma glucose and postprandial plasma glucose were positively correlated with HbA1c level (r = 0.725 and r = 0.673, both P < 0.001, respectively). For diagnosing diabetes, the AUC was 0.857 (95% confidence interval, 0.841-0.873), and the optimal cutoff for HbA1c was 6.3%, with the largest Youden index being 0.581. For diagnosing prediabetes, the AUC was 0.681 (95% confidence interval, 0.666-0.697), and the optimal cutoff for HbA1c was 5.9%, with the largest Youden index being 0.280. Conclusions: An HbA1c threshold of 6.3% was highly valuable for diagnosing newly diagnosed diabetes, and a value of 5.9% was weakly valuable for diagnosing prediabetes in community-based Chinese adults 40 years of age or older.

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Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study (队列简介：中国糖尿病患者肿瘤发生风险的纵向研究（REACTION研究）)

Abstract: The multi-center REACTION study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259 657 adults from the general population across the China.

Cited by 155 publications

References 24 publications

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Cutoff Point of HbA1c for Diagnosis of Diabetes Mellitus in Chinese Individuals

Diagnostic Efficiency of Hemoglobin A1c for Newly Diagnosed Diabetes and Prediabetes in Community-Based Chinese Adults Aged 40 Years or Older

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