Cohort Profile: Rationale and design of the fourth visit of the STANISLAS cohort: a familial longitudinal population-based cohort from the Nancy region of France

Ferreira, João Pedro; Girerd, Nicolas; Bozec, Erwan; Mercklé, Ludovic; Pizard, Anne; Bouali, Sanae; Eby, E.; Leroy, Céline; Machu, Jean‐Loup; Boivin, Jean‐Marc; Lamiral, Zohra; Rossignol, Patrick; Zannad, Faı̈ez

doi:10.1093/ije/dyx240

Cited by 40 publications

(56 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our population characteristics are comparable to other low-risk cohorts [ 31 , 32 ]. Moreover, similarly to Krokager et al [ 33 ], who reported short-term mortality risk of potassium levels in hypertensive patients from the nationwide Danish registry, or in the Lindner et al ED retrospective monocentric study [ 21 ], women were globally more susceptible to hypokalemia.…”

Section: Resultssupporting

confidence: 77%

See 1 more Smart Citation

Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Potassium disturbances are associated with adverse prognosis in patients with chronic conditions. Its prognostic implications in stable patients attending the emergency department (ED) is poorly described. Aims This study aimed to assess the prevalence of dyskalemia, describe its predisposing factors and prognostic associations in a population presenting the ED without unstable medical illness. Methods Post-hoc analysis of a prospective, cross-sectional, multicenter study in the ED of 11 French academic hospitals over a period of 8 weeks. All adults presenting to the ED during this period were included, except instances of self-drug poisoning, inability to complete selfmedication questionnaire, presence of an unstable medical illness and decline to participate in the study. All-cause hospitalization or deaths were assessed. Results A total of 1242 patients were included. The mean age was 57.2±22.3 years, 51% were female. The distribution according to potassium concentrations was: hypokalemia<4mmol/L

show abstract

Section: Resultssupporting

confidence: 77%

“…Our population characteristics are comparable to other low-risk cohorts [31,32]. Moreover, similarly to Krokager et al [33], who reported short-term mortality risk of potassium levels in All variables with a p-value < 0.1 in Table 1 were introduced into the model.…”

Section: Hospitalization and Deathsupporting

confidence: 84%

Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The STANISLAS Cohort has been described previously. 5 Briefly, it is a single-centre familial longitudinal cohort which includes 1006 families (4295 subjects) from the Nancy region of France recruited in 1993-1995. From 2011 to 2015, a total of 1705 subjects aged 20 to 75 years underwent their 4th examination using high-quality echocardiographic imaging at our department.…”

Section: Methodsmentioning

confidence: 99%

“…The STANISLAS Cohort has been described previously 5 . Briefly, it is a single‐centre familial longitudinal cohort which includes 1006 families (4295 subjects) from the Nancy region of France recruited in 1993–1995.…”

Section: Methodsmentioning

confidence: 99%

Circulating multimarker approach to identify patients with preclinical left ventricular remodelling and/or diastolic dysfunction

et al. 2021

Self Cite

View full text Add to dashboard Cite

Aims Biomarkers reflecting myocardial fibrosis and inflammation have been individually associated with left ventricular hypertrophy (LVH) and diastolic dysfunction (DD). However, the added value of a fibrosis-inflammation multimarker approach in a populational setting is yet to be studied. We evaluated the value of a multimarker approach to detect LVH and DD in a large population-based cohort. Methods and results In a prespecified analysis (BioSe-PreIC study) of the 4th visit of the STANISLAS cohort (1705 subjects, 47 ± 14 years, 47.4% men), we evaluated the ability of brain natriuretic peptide (BNP), Galectin-3 (GAL3), N-terminal propeptide of procollagen type III (P3NP), and soluble ST2 to predict LVH (LV mass > 116/100 g/m 2 for men/women) and DD using discrimination (C-index) and reclassification analysis (NRI). Participants with LVH and/or DD had significantly higher levels of BNP, GAL3, and ST2. Overall, the predictive value of clinical variables for LVH and/or DD was good (C-index ranging from 0.76 to 0.82) and the addition of BNP, Gal3, P3NP, and ST2 moderately but significantly improved predictive value (delta C-index = 0.03, P = 0.03 for LVH and 0.01, P = 0.01 for DD) and reclassification (NRI = 25.3, P = 0.02 for LVH and NRI = 32.7 for DD, P < 0.0001). Gal3, P3NP, and ST2 significantly improved predictive value (delta C-index = 0.01, P = 0.01) and reclassification (NRI = 31.3, P < 0.0001) for DD of top of clinical variables and BNP. Conclusions As the measurement of Gal3, P3NP, and ST2 results in marginal (even if significant) increase in the prediction of DD/LVH on top of routine evaluation, their systematic use should not be promoted in unselected healthy individuals to screen for preclinical DD. Further research is needed to determine whether a more personalized medicine approach combing proteomic and clinical scoring can amplify the added value of biomarkers to identify preclinical DD.

show abstract

“…Our study protocol included four phases, namely (1) the comparison of the measurements derived from the WTS and ART.LAB systems, (2) the devices' internal reproducibility analysis, (3) the inter-observer reproducibility analysis and (4) intra-observer reproducibility. For the first and second phase of the study protocol, both IMT measurements were performed in 188 consecutive participants from the fourth examination of the STANISLAS Cohort (Clinical Trial: NCT01391442) [16][17][18] by a senior imaging engineer (as the goal of this phase was to provide an optimal comparison of the results provided by the two devices). For the third phase of the protocol, 60 participants were consecutively included across three ongoing cohorts simultaneously conducted in our centre, in whom measurements were successively performed by three operators (one senior engineer and two research nurses).…”

Section: Populationsmentioning

confidence: 99%

Reproducibility in Echotracking Assessment of Local Carotid Stiffness, Diameter and Thickness in a Population-based Study (The STANISLAS Cohort Study)

Bozec¹,

Girerd²,

Ferreira³

et al. 2020

Artery Res

Self Cite

View full text Add to dashboard Cite

Background: Carotid Intima Media Thickness (IMT) and stiffness are associated with cardiovascular events. The study aims were to perform a head-to-head comparison of the Wall Track System (WTS) and ART.LAB for carotid IMT, distension and diameter echotracking measurements as well as inter-and intra-observer reproducibility. Methods: Echotracking measurements were performed with WTS and ART.LAB in 188 participants from the STANISLAS Cohort (mean age 47 ± 14 years). Inter-observer reproducibility analysis was performed in 60 patients consecutively included among the STANISLAS Cohort and two other ongoing cohorts, in whom measurements were successively performed by three operators. Results: The relative differences between WTS and ART.LAB in artery diameter measurements were minimal (mean difference −1.8%) while the differences in IMT and distension measurements were 6.1% and 4.3%, respectively. The Bland and Altman plots for diameter, distension and intima media thickness showed no measurement bias between ART.LAB and WTS. The internal reproducibility for carotid diameter was good with the two devices (≈2% SD). The ART.LAB performed ≈2-fold better than WTS for IMT internal reproducibility (5% vs. 12.5%, p < 0.0001) and distension internal reproducibility (6.3% vs. 12.4%, p < 0.0001). The inter-and intra-observer reproducibility for carotid diameter and IMT was good for both devices. Complete results were obtained in 1:50 min in ART.LAB and 11:13 min with WTS. Conclusion: ART.LAB and WTS show good agreement, with good inter-and intra-observer reproducibility with the two devices. Nevertheless, internal reproducibility of ART.LAB is better and measurements are easier to perform, favouring this device for carotid intima media thickness and stiffness measurements. H I G H L I G H T S • Our results show a good agreement between ART.LAB and WTS echotracking devices. • In our hands, internal reproducibility of ART.LAB is better than WTS. • Carotid stiffness and thickness measurements are easier/quicker with ART.LAB than with WTS.

show abstract

Cohort Profile: Rationale and design of the fourth visit of the STANISLAS cohort: a familial longitudinal population-based cohort from the Nancy region of France

Cited by 40 publications

References 28 publications

Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department

Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department

Circulating multimarker approach to identify patients with preclinical left ventricular remodelling and/or diastolic dysfunction

Reproducibility in Echotracking Assessment of Local Carotid Stiffness, Diameter and Thickness in a Population-based Study (The STANISLAS Cohort Study)

Contact Info

Product

Resources

About