Cohort profile: four early uranium processing facilities in the US and Canada

Golden, Ashley P.; Milder, Caitlin M.; Ellis, Elizabeth D.; Anderson, Jeri L.; Boice, John D.; Bertke, Stephen; Zablotska, Lydia B.

doi:10.1080/09553002.2021.1917786

Cited by 14 publications

(5 citation statements)

References 57 publications

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“…The U.S. and Canada study presented pooled cohort profiles of early uranium processing facilities, with a statistically significant SMR = 1.29 (95% CI: 1.04, 1.54) in males indicating an increased risk of dementia-related mortality in males from radiation exposure ( 58 ). This study did not report an ERR per unit radiation dose and thus it was excluded from the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…An inter-rater Kappa of 0.74 indicated substantial agreement between reviewers (52). After the full-text review was completed, 18 studies (26,(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71) met the eligibility criteria for data abstraction (Table 2), which included a total of 853,821 participants. Figure 1 shows the PRISMA flowchart.…”

Section: Literature Searchmentioning

confidence: 99%

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Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis

Srivastava

Chirikova

Birk³

et al. 2023

Radiation Research

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The number of people living with dementia is rising globally as life expectancy increases. Dementia is a multifactorial disease. Due to the ubiquity of radiation exposure in medical and occupational settings, the potential association between radiation and dementia, and its subtypes (Alzheimer's and Parkinson's disease), is of particular importance. There has also been an increased interest in studying dementia risks in connection with the long-term manned space travel proposed by The National Aeronautics and Space Administration (NASA). To our knowledge, the findings from epidemiological studies of ionizing radiation and dementia have not been previously synthesized using a meta-analytic approach. Our aim was to systematically review the literature on this topic, and use meta-analysis to generate a summary measure of association, assess publication bias and explore sources of heterogeneity across previous studies. We identified five types of exposed populations for this review: 1. survivors of atomic bombings in Japan; 2. patients treated with radiation therapy for cancer or other diseases; 3. occupationally exposed workers; 4. those exposed to environmental radiation; and 5. patients exposed to radiation from diagnostic radiation imaging procedures. We included studies that considered incident or mortality outcomes for dementia and its subtypes. Following PRISMA guidelines, we systematically searched the published literature indexed in PubMed between 2001 and 2022. We then abstracted the relevant articles, conducted a risk-of-bias assessment, and fit random effects models using the published risk estimates. After we applied our eligibility criteria, 18 studies were identified for review and retained for meta-analysis. For dementia (all subtypes), the summary relative risk was 1.11 (95% CI: 1.04, 1.18; P = 0.001) comparing individuals receiving 100 mSv of radiation to those with no exposure. The corresponding summary relative risk for Parkinson's disease incidence and mortality was 1.12 (95% CI 1.07, 1.17; P <0.001). Our results provide evidence that exposure to ionizing radiation increases the risk of dementia. However, our findings should be interpreted with caution due to the small number of included studies. Longitudinal studies with improved exposure characterization, incident outcomes, larger sample size, and the ability to adjust for effects of potential confounders are needed to better assess the possible causal link between ionizing radiation and dementia.

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Section: Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis

Srivastava

Chirikova

Birk³

et al. 2023

Radiation Research

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“…(In Russian). DOI:10.33266/1024-6177-2024-69-1-73-76 тистически значимые риски (1,29; 95 % доверительный интервал: 1,04; 1,54) [7].…”

Section: Abstract: Uranium Compounds Personnel Of Radiation Hazardous...unclassified

“…Так, Golden A.P. et al описали когорту из 12 400 работников [7], а Rage E. et al -когорту из 124 507 работников [10]. Тем не менее, представленная когорта представляет собой базу данных, содержащую верифицированные сведения, необходимые для доказательной оценки влияния урана и продуктов его распада на здоровье персонала, задействованного в работах с ним.…”

Section: результатыunclassified

The Sublimate Production Cohort of the Siberian Chemical Plant (Dosimetric Characteristics)

Kalinkin,

Milto,

Takhauov

et al. 2024

MEDICAL RADIOLOGY AND RADIATION SAFETY

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Introduction: Uranium, which is the raw material basis of the nuclear industry, is capable of causing adverse medical and biological consequences for workers who come into contact with its compounds in the course of their professional activities. In order to study this effect and to study in detail the biomedical consequences of the effects of uranium compounds on the body of personnel of nuclear power facilities, it is necessary to form a cohort of persons engaged in work with uranium compounds. One of the key elements of the uranium conversion technology carried out within the framework of sublimation production is the production of raw uranium hexafluoride for subsequent isotopic enrichment. Purpose: To form and characterize a cohort of sublimate production of the personnel of the Siberian Chemical Plant involved in work with uranium compounds in the period 1953–2000. Material and methods: The source of information was the regional medical dosimetric register of Seversk Biophysical Research Center, containing information on all current and former employees of the Siberian Chemical Plant (about 65,000 people) from the moment of the company’s foundation to the present. Results: A cohort of Siberian Chemical Plant workers involved in work with uranium compounds in the period 1953–2000 has been formed and described. The cohort consists of 577 people (475 men and 102 women). Biomedical information and dosimetric information about the employees included in the cohort are included in the created database of the personnel of the Siberian Chemical Plant involved in working with uranium compounds in the period 1953–2000. Conclusion: The formed cohort and database will allow conducting epidemiological studies to assess the morbidity and mortality of personnel due to malignant neoplasms, as well as making scientifically sound conclusions about the role of uranium compounds in the occurrence and mortality due to malignant neoplasms.

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“…Golden et al. reviewed the outcome of 12,400 workers of uranium facilities in the USA between 1930 until 2017 and they found no increased renal mortality ( 134 ).…”

Section: Occupation and The Kidneymentioning

confidence: 99%

Where do you live and what do you do? Two questions that might impact your kidney health

Aoun¹,

Chelala²

2022

Front. Nephrol.

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In many cases the social determinants of health need to be assessed through their interaction with environmental factors. This review looks at the impact of physical location and occupation of individuals on their kidney health. It examines the effect of living at high altitude on kidney function and the relationship between extreme cold or hot temperatures and the incidence of kidney injury. It reviews as well the many occupations that have been linked to kidney disease in high-income and low-and-middle-income countries. As a conclusion, this overview proposes preventive recommendations that could be individualized based on weather, altitude, socio-economic level of the country and occupation of the individual.

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Cohort profile: four early uranium processing facilities in the US and Canada

Cited by 14 publications

References 57 publications

Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis

Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis

The Sublimate Production Cohort of the Siberian Chemical Plant (Dosimetric Characteristics)

Where do you live and what do you do? Two questions that might impact your kidney health

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