Cohort profile: Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort

Abstract

The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort study aims to investigate health trajectories of individuals following hospitalisation for myocardial infarction (MI). Methods and Results EMMACE is a linked multicenter prospective cohort study of 14 899 patients with MI admitted to 77 hospitals in England who participated in the EMMACE-3 and -4 studies between 1st November 2011 and 24th June 2015. Long term follow-up of the EMMACE cohorts was conducted through the EMMACE-XL (27th September 2020 to 31st March 2022) and EMMACE-XXL (1st July 2021 to 1st July 2023) studies. EMMACE collected individual participant data for health related quality of life (HRQoL) measured by EuroQol5-dimensions (EQ5D-3 L) and visual analogy scale (EQVAS) at admission, 1 month, 6 months,12 months and 10 years follow up, as well as medications, medication adherence, beliefs about medicines, satisfaction with Information about Medicines Scale [SIMS] and illness perceptions. Participant data were deterministically linked to the Myocardial Infarction National Audit Project (MINAP) for baseline treatments and comorbidities information, Hospital Episodes Statistics Admitted Patient Care (for cause-specific hospitalisations data), and the Office for National Statistics (for mortality data) up to 2020. Conclusion EMMACE is a nationwide prospective cohort that will provide unique insights into fatal and non-fatal outcomes, medications adherence, and health related quality of life following MI. Trial registration: ClinicalTrials.gov NCT01808027 and NCT01819103