Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Nordström, Tanja; Miettunen, Jouko; Auvinen, Juha; Ala‐Mursula, Leena; Keinänen‐Kiukaanniemi, Sirkka; Veijola, Juha; Järvelin, Marjo‐Riitta; Sebért, Sylvain; Männikkö, Minna

doi:10.1093/ije/dyab109

Cited by 126 publications

(136 citation statements)

References 30 publications

(29 reference statements)

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“…It is true that a low response rate can cause bias; non‐participants may be different in relation to oral hygiene and dental visiting habits and overall health‐related habits such as smoking and diet. In this follow‐up study, it was observed that those who participated were more often from a higher social class, were employed, were married, and had children compared to those who did not participate (Nordström et al, 2022). However, as the focus of this study was on the association between periodontal inflammatory condition and eczemas, we believe that the somewhat low participation rate is not a major concern.…”

Section: Discussionmentioning

confidence: 98%

Association between bleeding periodontal pockets and eczemas: Results of the Northern Finland Birth Cohort 1966

Tursas

Ylipalosaari

Sinikumpu

et al. 2022

J Clinic Periodontology

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Aim To investigate whether the periodontal condition as measured by bleeding periodontal pockets is associated with atopic dermatitis, seborrheic dermatitis, and eczema nummulare. Materials and Methods The study population (n = 1871) was obtained from the 46‐year follow‐up study of the Northern Finland Birth Cohort 1966 study (NFBC1966). The periodontal condition was measured by the number of sites with bleeding periodontal pockets that were ≥4 mm deep. The whole skin of the participants was clinically examined, and diagnoses of skin diseases were made according to the International Classification of Diseases. Prevalence rate ratios (PRR) and 95% confidence intervals (95% CIs) were estimated using Poisson regression models with robust error variance. Results In this cohort, comprising 46‐year‐old participants of NFBC1966, the presence of 1–3 and ≥4 bleeding‐deepened periodontal pockets (≥4 mm deep) were associated with seborrheic dermatitis (PRR 1.9, 95% CI: 1.3–2.8 and PRR 2.2, 95% CI: 1.4–3.3, respectively) and with eczema nummulare (PRR 1.7, 95% CI: 0.9–3.1 and PRR 1.7, 95% CI: 0.9–3.3, respectively). For non‐smokers, the corresponding estimates were 1.7 for seborrheic dermatitis (95% CI: 1.1–2.6) and 1.8 (95% CI: 1.1–3.1) and 1.4 for eczema nummulare (95% CI: 0.7–2.9) and 1.2 (95% CI: 0.5–2.9), respectively. No association was found between bleeding‐deepened periodontal pockets and atopic dermatitis. Further adjustments for C‐reactive protein, diabetes, and inflammatory diseases did not essentially change the risk estimates among either the total population or the non‐smokers. Conclusion Bleeding periodontal pockets appeared to be associated with the presence of seborrheic dermatitis and eczema nummulare.

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Section: Discussionmentioning

confidence: 98%

Association between bleeding periodontal pockets and eczemas: Results of the Northern Finland Birth Cohort 1966

Tursas

Ylipalosaari

Sinikumpu

et al. 2022

J Clinic Periodontology

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“…The study sample may not fully represent the invited sample. Based on the attrition analyses performed for the NFBC 1966 clinical study (Nordström et al., 2021), the participants were more often females, employed and from higher social class. They were also more likely married, had children and higher education.…”

Section: Discussionmentioning

confidence: 99%

Association of temporomandibular disorders with pain sensitivity: A cohort study

Knuutila

Kivipuro

Näpänkangas

et al. 2021

European Journal of Pain

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“…In our study the prevalence of T2D was 4.2% which is less than the estimated age-standardized prevalence of T2D in Finland at 8% and 10% in females and males [ 31 ]. This difference may be attributed to attrition in participation rate at 46 years follow-up as reported in the cohort profile [ 21 ]. On the other hand, the prevalence of depression was 19.2% in our study.…”

Section: Discussionmentioning

confidence: 99%

“…We used data from the Northern Finland Birth Cohort 1966 (NFBC1966) as described previously [ 21 ]. The design of the data collections used in the analyses are described in the study flowchart (Supplementary Fig.…”

Section: Methodsmentioning

confidence: 99%

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

et al. 2022

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Objectives Type 2 diabetes (T2D) and comorbid depression challenges clinical management particularly in individuals with overweight. We aim to explore the shared etiology, via lifecourse adiposity, between T2D and depression. Methods We used data from birth until 46years from Northern Finland Birth Cohort 1966 (n = 6,372; 53.8% females). We conducted multivariate analyses on three outcomes: T2D (4.2%), depression (19.2%) and as comorbidity (1.8%). We conducted (i) Path analysis to clarify time-dependent body mass index (BMI) related pathways, including BMI polygenic risk scores (PRS); and (ii) Cox regression models to assess whether reduction of overweight between 7years and 31years influence T2D, depression and/or comorbidity. The models were tested for covariation with sex, education, smoking, physical activity, and diet score. Results The odd ratios (OR) of T2D in individuals with depression was 1.68 [95% confidence interval (CI): 1.34–2.11], and no change in estimate was observed when adjusted for covariates. T2D and comorbidity showed similar patterns of relationships in the path analyses (P < 0.001). The genetic risk for obesity (PRS BMI) did not show direct effect on T2D or comorbidity in adulthood but indirectly through measures of adiposity in early childhood and mid-adulthood in the path analysis (P < 0.001). Having early-onset of overweight at 7years and 31years showed highest risk of T2D (OR 3.8, 95%CI 2.4–6.1) and comorbidity (OR 5.0, 95%CI 2.7–9.5), with mild-to-moderate attenuation with adjustments. Depression showed no significant associations. Conclusions We found evidence for overweight since childhood as a risk factor for T2D and co-morbidity between T2D and depression, influenced moderately by lifestyle factors in later life. However, no shared early life adiposity related risk factors were observed between T2D and depression when assessed independently in this Finnish setting.

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Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Cited by 126 publications

References 30 publications

Association between bleeding periodontal pockets and eczemas: Results of the Northern Finland Birth Cohort 1966

Association between bleeding periodontal pockets and eczemas: Results of the Northern Finland Birth Cohort 1966

Association of temporomandibular disorders with pain sensitivity: A cohort study

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

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