Cohesive tensile strength of human LASIK wounds with histologic, ultrastructural, and clinical correlations

Response of the posterior corneal surface to myopic laser in situ keratomileusis with different ablation depths

“…In contrast, a hypercellular fibrotic stromal scar occurs at the wound margin with a gradual increase in tensile wound strength up to 3.5 years after LASIK. 26,27 These findings are consistent with the observed shift toward prolateness of the posterior cornea after surgery. With the central cornea being weaker than the periphery, greater deformation occurs in the center, leading to greater steepening of the central posterior cornea.…”

Fulminant Culture Negative Endophthalmitis as a New Entity, Toxic Posterior Segment Syndrome?

“…Myopic LASIK severs collagen bands and thins the cornea, reducing its integrity and strength [10]. The tensile strength of a cornea with a LASIK flap may be reduced significantly in comparison to a normal cornea [11]. Although there are no documented cases of a patient with a history of LASIK developing a post cataract wound leak, we propose that these factors listed above may have demonstrated a significant role for the patient becoming seidel positive on day 15.…”

A perfluoropolyether corneal inlay for the correction of refractive error

“…The cause of the cellular degeneration where a polymer inlay has been implanted into the stromal tissue is likely to involve several factors. Cutting the cornea with a microkeratome blade during the surgical procedure to create a corneal flap is known to create a wound, which never fully heals but resolves as scar tissue [35,36]. Although this is insufficient in itself to interfere with visual outcomes, as demonstrated by LASIK surgery (where a corneal flap made using a microkeratome cut allows access to the stromal tissue for the purposes of laser ablation to achieve refractive correction), the cut does result in direct physical damage to keratocytes present in blade track.…”