Cohesin regulates promoter-proximal pausing of RNA Polymerase II by limiting recruitment of super elongation complex
Shoin Tei,
Toyonori Sakata,
Atsunori Yoshimura
et al.
Abstract:Cohesin is a ring-shaped complex, responsible for establishing sister chromatid cohesion and forming topologically associating domains (TADs) and chromatin loops. Loss-of-function mutations in cohesin subunits and its regulatory factors can cause Cornelia de Lange syndrome (CdLS). Because dysregulated gene expression was observed in CdLS, it has long been thought that cohesin plays a regulatory role in transcription. Here, we investigated the effect of acute cohesin depletion on transcription and observed that… Show more
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