Coherent-weighted three-dimensional image reconstruction in linear-array-based photoacoustic tomography

Wang, Depeng; Wang, Yuehang; Zhou, Yang; Lovell, Jonathan F.; Xia, Jun

doi:10.1364/boe.7.001957

Cited by 37 publications

(29 citation statements)

References 15 publications

(23 reference statements)

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“…With 50 Hz pulse repetition frequency, each 40-mm scan took 8 seconds, which was only one fifth of the imaging time mentioned in our previous study [39]. Photographs of the arm and palm are shown in Figs Figs.…”

Section: Human Imagingmentioning

confidence: 90%

“…Also, because most blood vessels were located within 15 mm of axial depths, we did not use any additional reconstruction methods to further improve the spatial resolution nor contrast ratio. For deep tissue imaging (> 30 mm), we could use our slitbase PACT [40] or coherent-weighted 3D reconstruction [39] to improve the image quality. It should also be noted that our current field of view is limited by the small lateral dimension of the transducer array (38 mm for L7-4).…”

Section: Human Imagingmentioning

confidence: 99%

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Deep tissue photoacoustic computed tomography with a fast and compact laser system

Wang

et al. 2016

Biomed. Opt. Express

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Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 -200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diodepumped laser used in this study had a miniature footprint (13 × 14 × 7 cm 3 ), weighed only 1.6 kg, and outputted up to 80 mJ per pulse at 1064 nm. In vitro, the laser system readily provided over 4 cm PACT depth in chicken breast tissue. In vivo, in addition to high resolution, non-invasive brain imaging in living mice, the system can operate at 50 Hz, which enabled high-speed cross-sectional imaging of murine cardiac and respiratory function. The system also provided high quality, high-frame rate, and non-invasive three-dimensional mapping of arm, palm, and breast vasculature at multi centimeter depths in living human subjects, demonstrating the clinical viability of compact lasers for PACT.

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Section: Human Imagingmentioning

confidence: 90%

Section: Human Imagingmentioning

confidence: 99%

Deep tissue photoacoustic computed tomography with a fast and compact laser system

Wang

et al. 2016

Biomed. Opt. Express

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“…Then these beamformed data for all scanning lines stack together to form 3D photoacoustic imaging [7]. This 3D photoacoustic image suffers from poor elevation resolution out of the focal point.…”

Section: A Das Beamforming Techniquementioning

confidence: 99%

“…This 3D photoacoustic image suffers from poor elevation resolution out of the focal point. To reduce the effect of the poor elevation resolution out of the focus point, the received RF data will be beamformed in the lateral then in the elevation directions to generate DAS (3D) beamforming technique [7]. In this beamforming technique, the FOV of each transducer element in the lateral and elevation direction will be taken on account.…”

Section: A Das Beamforming Techniquementioning

confidence: 99%

“…For instance, Schwarz et.al [6] have applied bidirectional scan by using linear array transducer. Wang et.al [7] have combined coherent factor (CF) with focal line (FL) technique to improve elevation resolution when linear array transducer is used. In this study, the elevation resolution of the 3D photoacoustic image will be improved when linear array transducer is used by applying Filter delay multiply and sum (FDMAS) beamforming technique in 3D photoacoustic imaging.…”

Section: Introductionmentioning

confidence: 99%

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Elevation resolution enhancement in 3D photoacoustic imaging using FDMAS beamforming

Alshaya¹,

Harput²,

Cowell³

et al. 2017

2017 IEEE International Ultrasonics Symposium (IUS)

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Abstract-Photoacoustic imaging is a non-invasive and nonionizing imaging technique that combines the spectral selectivity of laser excitation with the high resolution of ultrasound imaging. It is possible to identity the vascular structure of the cancerous tissue using this imaging modality. However, elevation and lateral resolution of photoacoustic imaging is usually poor for imaging target. In this study, three dimension filter delay multiply and sum beamforming technique (FDMAS(3D)) is used to improve the resolution and enhance the signal to noise ratio (SNR) of the 3D photoacoustic image that is created by using linear array transducer. This beamforming technique showed improvement in the elevation by 36% when its compared with three dimension delay and sum beamforming technique (DAS(3D)). In addition, it enhanced the SNR by 13 dB compared with DAS (3D).

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Second generation slit‐based photoacoustic tomography system for vascular imaging in human

Wang¹,

Wang²,

Hubbell³

et al. 2016

Journal of Biophotonics

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Slit-based photoacoustic tomography is a newly developed technique that improves the elevation numerical aperture of a linear array through acoustic diffraction. The slit, placed at the acoustic focus of a linear array, effectively forms an array of virtual detectors with high receiving angle, which subsequently improves the elevation resolution. However, due to the complex implementation, our original system could only image phantoms and sacrificed animals. In this report, the system has been significantly improved. In particular, we designed a slit holder that can be directly mounted to the transducer array for easy adjustment of slit width and simultaneous scanning of both the array and the slit. To enlarge the imaging field of view, we replaced the single circular optical fiber bundle with a bifurcated line fiber bundle which moved simultaneously with the array and the slit. The data acquisition system has also been updated to double the imaging speed. With these improvements, the new system can image a 3.8 × 4 cm2 region within 40 seconds and the object only needs to be coupled through ultrasound gel. We successfully used the system to image vasculatures in the palm and forearm of human volunteers.

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Coherent-weighted three-dimensional image reconstruction in linear-array-based photoacoustic tomography

Cited by 37 publications

References 15 publications

Deep tissue photoacoustic computed tomography with a fast and compact laser system

Deep tissue photoacoustic computed tomography with a fast and compact laser system

Elevation resolution enhancement in 3D photoacoustic imaging using FDMAS beamforming

Second generation slit‐based photoacoustic tomography system for vascular imaging in human

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