Coherent backscattering spectroscopy

Kim, Young L.; Liu, Yang; Turzhitsky, Vladimir; Roy, Hemant K.; Wali, Ramesh K.; Backman, Vadim

doi:10.1364/ol.29.001906

Cited by 72 publications

(94 citation statements)

References 9 publications

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“…15,16 This reflectance method is not hindered by the measurement geometry limitations that are present in the integrating sphere technique and does not require any manipulation of the sample. LEBS is capable of measuring the reflectance distribution at small scattering distances (i.e., separations between incident and collected ray pairs well below the transport mean free path length or even the mean free path length) resulting in a high sensitivity to the phase function.…”

Section: Introductionmentioning

confidence: 99%

Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy

Turzhitsky¹,

Radosevich²,

Rogers³

et al. 2011

J. Biomed. Opt.

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Abstract. Low-coherence enhanced backscattering (LEBS) is a depth selective technique that allows noninvasive characterization of turbid media such as biological tissue. LEBS provides a spectral measurement of the tissue reflectance distribution as a function of distance between incident and reflected ray pairs through the use of partial spatial coherence broadband illumination. We present LEBS as a new depth-selective technique to measure optical properties of tissue in situ. Because LEBS enables measurements of reflectance due to initial scattering events, LEBS is sensitive to the shape of the phase function in addition to the reduced scattering coefficient (μ * s ). We introduce a simulation of LEBS that implements a two parameter phase function based on the Whittle-Matérn refractive index correlation function model. We show that the LEBS enhancement factor (E) primarily depends on μ * s , the normalized spectral dependence of E (S n ) depends on one of the two parameters of the phase function that also defines the functional type of the refractive index correlation function (m), and the LEBS peak width depends on both the anisotropy factor (g) and m. Three inverse models for calculating these optical properties are described and the calculations are validated with an experimental measurement from a tissue phantom. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy

Turzhitsky¹,

Radosevich²,

Rogers³

et al. 2011

J. Biomed. Opt.

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“…Enhanced backscattering using a broadband, low spatial-coherence source has recently been employed for depth-resolved profiling of biological tissue [5]. With low-spatial coherence light, optical paths with a transverse distance at the surface larger than the spatial coherence length do not contribute to enhanced backscattering.…”

Section: Introductionmentioning

confidence: 99%

Broadband enhanced backscattering spectroscopy of strongly scattering media

Muskens¹,

Lagendijk²

2008

Opt. Express

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Abstract:We report on a new experimental method for enhanced backscattering spectroscopy (EBS) of strongly scattering media over a bandwidth from 530-1000 nm. The instrument consists of a supercontinuum light source and an angle-dependent detection system using a fiber-coupled grating spectrometer. Using a combination of two setups, the backscattered intensity is obtained over a large angular range and using circularly polarized light. We present broadband EBS of a TiO 2 powder and of a strongly scattering porous GaP layer. In combination with theoretical model fits, the EBS system yields the optical transport mean free path over the available spectral window.

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“…Furthermore, our finding that the local scattering power increased with age in the control mice is also in agreement with the studies in cervical cancer. 33 The previous animal studies 12,14,15 of precancerous alterations in colon cancer focused on the utility of the spectral properties of LEBS. On the other hand, our current study reports that a different quantification of LEBS ͑i.e., the enhancement factor͒ has the potential as an easily measurable robust biomarker, not dependent on the illumination intensity.…”

Section: Results and Discussion Of The Pilot Animal Studymentioning

confidence: 99%

“…Any changes in the LEBS enhancement factor are directly related to changes in p͑r Ͻ L sc ͒. In our previous studies, [11][12][13][14][15][16] low-spatial-coherence illumination was implemented in EBS to isolate low-order scattering by dephasing the conjugated time-reversed paths outside its spatially coherent area when L sc Ӷ l s * . In this case, the coherent area ͑or the transverse modes͒ can be as small as L sc 2 =50 2 to 100 2 m 2 , while l s * is of the order of a few millimeters in biological tissue.…”

Section: Introductionmentioning

confidence: 99%

Enhancement factor in low-coherence enhanced backscattering and its applications for characterizing experimental skin carcinogenesis

Liu

Song

et al. 2010

J. Biomed. Opt.

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Abstract. We experimentally study potential mechanisms by which the enhancement factor in low-coherence enhanced backscattering ͑LEBS͒ can probe subtle variations in radial intensity distribution in weakly scattering media. We use enhanced backscattering of light by implementing either ͑1͒ low spatial coherence illumination or ͑2͒ multiple spatially independent detections using a microlens array under spatially coherent illumination. We show that the enhancement factor in these configurations is a measure of the integrated intensity within the localized coherence or detection area, which can exhibit strong dependence on small perturbations in scattering properties. To further evaluate the utility of the LEBS enhancement factor, we use a well-established animal model of cutaneous two-stage chemical carcinogenesis. In this pilot study, we demonstrate that the LEBS enhancement factor can be substantially altered at a stage of preneoplasia. Our animal result supports the idea that early carcinogenesis can cause subtle alterations in the scattering properties that can be captured by the LEBS enhancement factor. Thus, the LEBS enhancement factor has the potential as an easily measurable biomarker in skin carcinogenesis.

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Coherent backscattering spectroscopy

Cited by 72 publications

References 9 publications

Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy

Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy

Broadband enhanced backscattering spectroscopy of strongly scattering media

Enhancement factor in low-coherence enhanced backscattering and its applications for characterizing experimental skin carcinogenesis

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